Detailed information of TA system TA155923

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): holin-SprF1/-
• Location: 2086930..2087405
• Replicon: chromosome
• Accession: NZ_CP053075
• Organism: Staphylococcus aureus strain SA01

Toxin (Protein)

• Gene name: holin
• Uniprot ID: -
• Locus tag: HK402_RS10445
• Protein ID: WP_000387655.1
• Coordinates: 2086930..2087232 (-)
• Length: 101 a.a.

Antitoxin (RNA)

Gene name	SprF1
Locus tag	-
Coordinates	2087281..2087405 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HK402_RS10430	2082750..2083703	-	954	WP_000766912.1	ornithine cyclodeaminase family protein	-
HK402_RS10435	2084380..2085120	-	741	WP_170172381.1	CPBP family intramembrane metalloprotease	-
HK402_RS10440	2085465..2086919	-	1455	WP_000930251.1	N-acetylmuramoyl-L-alanine amidase	-
HK402_RS10445	2086930..2087232	-	303	WP_000387655.1	phage holin	Toxin
-	2087281..2087405	+	125	-	-	Antitoxin
HK402_RS10455	2087430..2087577	-	148	Protein_2020	putative holin-like toxin	-
HK402_RS10460	2087771..2088070	-	300	WP_000466781.1	DUF2951 family protein	-
HK402_RS10465	2088116..2088280	-	165	WP_000916020.1	XkdX family protein	-
HK402_RS10470	2088273..2088662	-	390	WP_001166602.1	DUF2977 domain-containing protein	-
HK402_RS10475	2088662..2090128	-	1467	WP_000067150.1	BppU family phage baseplate upper protein	-
HK402_RS10480	2090128..2092038	-	1911	WP_170172382.1	hypothetical protein	-
HK402_RS10485	2092054..2092344	-	291	WP_000179860.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	hlb / groEL	2085465..2137734	52269

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Holin (1-71)

Sequences

Toxin

Protein

• Length: 101 a.a.
• Molecular weight: 11127.85 Da
• Isoelectric Point: 9.6587

>T155923 WP_000387655.1 NZ_CP053075:c2087232-2086930 [Staphylococcus aureus]
MEAKVITRYIVLILALVNQFLANKGISPIPVDEESVSSIILTVIALYTTYKDNPTSQEGRWANQKLKKYKAESKYRKATG
QAPVKEVIAPTNMNDTNDLG

Nucleotide

• Length: 303 bp

>T155923 NZ_CP068820:c2090168-2089770 [Escherichia coli]
ATGCGGGTATTCAAAACAAAACTTATTCGCCTGCAACTTACAGCAGAGGAACTTGATGCGTTAACGGCGGATTTTATTTC
CTATAAGCGTGACGGTGTTTTGCCAGATATATTTGGTCGCGATGCACTCTACGACGACTCGTTTACCTGGCCATTAATCA
AATTTGAGCGAGTTGCTCATATTCATCTGGCAAATGTGAATAATCCATTTCCGCCACAGTTGCGCCAATTCAGCAGAACG
AATGACGAAGCGCATTTGGTATATTGTCAGGGTGCGTTTGATGAGCAAGCATGGTTGCTCATTGCCATTCTGAAGCCTGA
ACCTCATAAACTGGCTCGAGATAACAACCAAATGCATAAAATTGGAAAAATGGCAGAAGCGTTTCGCATGCGTTTTTGA

Antitoxin

Nucleotide

• Length: 125 bp

>AT155923 NZ_CP053075:2087281-2087405 [Staphylococcus aureus]
ATTTGATATTTATATTATGATGTGTTAATTTATATATAGAAAAAGGGCAACATGCGGAAACATGTCACCCTAGTGAGCCC
GTTAAAAAGACGGTGACCTCTTTTATATGATTAATAAATAACCAT

Structures

Antitoxin