Detailed information of TA system TA155909

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): SprA2-SprA2AS/-
• Location: 2507581..2507765
• Replicon: chromosome
• Accession: NZ_CP053070
• Organism: Staphylococcus aureus strain HL20709 isolate HL20709

Toxin (Protein)

• Gene name: SprA2
• Uniprot ID: A0A2P7CQJ7
• Locus tag: HH313_RS12505
• Protein ID: WP_000482647.1
• Coordinates: 2507658..2507765 (-)
• Length: 36 a.a.

Antitoxin (RNA)

Gene name	SprA2AS
Locus tag	-
Coordinates	2507581..2507641 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HH313_RS12490	2503091..2503258	-	168	WP_031845053.1	hypothetical protein	-
HH313_RS12495	2503489..2505222	-	1734	WP_000488493.1	ABC transporter ATP-binding protein/permease	-
HH313_RS12500	2505298..2507010	-	1713	WP_001064821.1	ABC transporter ATP-binding protein/permease	-
-	2507581..2507641	+	61	-	-	Antitoxin
HH313_RS12505	2507658..2507765	-	108	WP_000482647.1	type I toxin-antitoxin system Fst family toxin	Toxin
HH313_RS12510	2507898..2508284	-	387	WP_000779353.1	flippase GtxA	-
HH313_RS12515	2508552..2509694	+	1143	WP_001176863.1	glycerate kinase	-
HH313_RS12520	2509754..2510413	+	660	WP_000831298.1	membrane protein	-
HH313_RS12525	2510596..2511807	+	1212	WP_001191921.1	multidrug effflux MFS transporter	-
HH313_RS12530	2511930..2512403	-	474	WP_000456483.1	GyrI-like domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Sequences

Toxin

Protein

• Length: 36 a.a.
• Molecular weight: 4012.76 Da
• Isoelectric Point: 10.4935

>T155909 WP_000482647.1 NZ_CP053070:c2507765-2507658 [Staphylococcus aureus]
MFNLLIDIMTSALSGCLVAFFAHWLRTRNNKKGDK

Nucleotide

• Length: 108 bp

>T155909 NZ_CP068819:c4511095-4510745 [Escherichia coli]
ATGGTAAAGAAAAGTGAATTTGAACGGGGAGACATTGTGCTGGTTGGCTTTGATCCAGCAAGCGGCCATGAACAGCAAGG
TGCTGGTCGACCTGCGCTTGTGCTCTCCGTTCAAGCCTTTAATCAACTGGGAATGACGCTGGTGGCCCCCATTACGCAGG
GCGGAAATTTTGCCCGTTATGCCGGATTTAGCGTTCCTTTACATTGCGAAGAAGGCGATGTGCACGGCGTGGTGCTGGTG
AATCAGGTGTGGATGATGGATCTACGCGCCCGGCTGGCAAAGCGTATTGGTCTGGCTGCGGGTGAGGTGGTGGAAGAGGC
GTTATTACGTTTGCAGGCGGTGGTGGAATAA

Antitoxin

Nucleotide

• Length: 61 bp

>AT155909 NZ_CP053070:2507581-2507641 [Staphylococcus aureus]
TACATAATAAATTGAACATCTAAATACACCAAATCCCCTCACTACTGCCATAGTGAGGGGA

Structures

Toxin

• AlphaFold DB: A0A2P7CQJ7

Antitoxin