Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe-RelB
Location 2482310..2482827 Replicon chromosome
Accession NZ_CP053070
Organism Staphylococcus aureus strain HL20709 isolate HL20709

Toxin (Protein)


Gene name yoeB Uniprot ID A0A2S6D1N9
Locus tag HH313_RS12370 Protein ID WP_000113263.1
Coordinates 2482310..2482576 (-) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID T1YB60
Locus tag HH313_RS12375 Protein ID WP_000584499.1
Coordinates 2482576..2482827 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HH313_RS12345 2477570..2478106 - 537 WP_000185901.1 GNAT family N-acetyltransferase -
HH313_RS12350 2478519..2479343 - 825 WP_000594633.1 formate/nitrite transporter family protein -
HH313_RS12355 2479547..2479729 - 183 WP_000079140.1 hypothetical protein -
HH313_RS12360 2479816..2480283 - 468 WP_000153338.1 SRPBCC domain-containing protein -
HH313_RS12365 2480469..2482016 - 1548 WP_000727757.1 zinc ABC transporter substrate-binding lipoprotein AdcA -
HH313_RS12370 2482310..2482576 - 267 WP_000113263.1 Txe/YoeB family addiction module toxin Toxin
HH313_RS12375 2482576..2482827 - 252 WP_000584499.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
HH313_RS12380 2483000..2483091 - 92 Protein_2393 hypothetical protein -
HH313_RS12385 2483098..2483697 - 600 WP_000162810.1 DsbA family protein -
HH313_RS12390 2483716..2484078 - 363 WP_000819839.1 DUF4467 domain-containing protein -
HH313_RS12395 2484333..2485583 + 1251 WP_001012236.1 FemA/FemB family glycyltransferase FmhA -
HH313_RS12400 2485680..2486411 - 732 WP_000615464.1 amino acid ABC transporter ATP-binding protein -
HH313_RS12405 2486408..2487127 - 720 WP_000479576.1 amino acid ABC transporter permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(8-88)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-74)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10437.01 Da        Isoelectric Point: 10.1628

>T155908 WP_000113263.1 NZ_CP053070:c2482576-2482310 [Staphylococcus aureus]
MARLNITFSPQAFEDYKYFQQNDKKMVKKINELLKSIDRNGALKGIGKPEKLKSNLTGYYSRRINHEHRLVYTVDDNHIK
IASCKYHY

Download         Length: 267 bp

>T155908 NZ_CP068819:c4499373-4499083 [Escherichia coli]
ATGAACTATGAGCTGGCGTTTGATCCGCGGGCGCTGAAAGAGTGGCAAAAACTGGGCGTGACAGTCCGGGAACAATTTAA
AAAAAAGCTTGAGGATGTGCTGAAAAGGCCGCGCAATCCATCGGCTAAACTGCGGGATTTACCGGACTGCTACAAAATTA
AGCTGCGCACACAGGGATATCGCCTGGTTTATCAGGTTAACGATAAAGAGTTGCTCGTGTTGGTGATAGCTATTGGTAAG
AGAGAGAACTCAGCCGTTTATGAAGACGCGACTAAACGGCTGGATGAGTGA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9433.60 Da        Isoelectric Point: 4.3407

>AT155908 WP_000584499.1 NZ_CP053070:c2482827-2482576 [Staphylococcus aureus]
MIIKNYSYARQNLKALMTKVNDDSDMVTVTSTDDKNVVIMSESDYNSMMETLYLQQNPNNAEHLAQSIADLERGKTITKD
IDV

Download         Length: 252 bp

>AT155908 NZ_CP068819:c4499605-4499363 [Escherichia coli]
ATGGCCACACTTAACGTCCGCCTGGATGACAAACTGAAAAATGAGGCTTATGCGGTGCTGGAAAAATTAAATATCACGCC
TACTGAAGCAGTGCGGCTGCTGTTTCAGTACGTTGCGGAAAATGGACGAATGCCGGTAAAAACGCTCACTGTCAGTGATA
GTGAAGAAGCCTTGTTACGCACTGTCAGGGAACGACTGGCCAACCCACAAGAGGCCATTAAGGTCCGACTGGATGAACTA
TGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2S6D1N9

Antitoxin

Source ID Structure
PDB 6L8G
PDB 6L8F
PDB 7BWF
PDB 6L8E
AlphaFold DB T1YB60

References