Detailed information of TA system TA155907

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): sprG-sprF/-
• Location: 2220810..2221073
• Replicon: chromosome
• Accession: NZ_CP053070
• Organism: Staphylococcus aureus strain HL20709 isolate HL20709

Toxin (Protein)

• Gene name: SprG3
• Uniprot ID: Q2FWA7
• Locus tag: HH313_RS11030
• Protein ID: WP_001802298.1
• Coordinates: 2220969..2221073 (-)
• Length: 35 a.a.

Antitoxin (RNA)

Gene name	SprF2
Locus tag	-
Coordinates	2220810..2220974 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HH313_RS11010	2217047..2217712	-	666	WP_001024088.1	SDR family oxidoreductase	-
HH313_RS11015	2217864..2218184	+	321	WP_000139802.1	Zn(II)-responsive metalloregulatory transcriptional repressor CzrA	-
HH313_RS11020	2218186..2219163	+	978	WP_000019732.1	CDF family zinc efflux transporter CzrB	-
HH313_RS11025	2219429..2220520	+	1092	WP_000495695.1	hypothetical protein	-
-	2220810..2220974	+	165	-	-	Antitoxin
HH313_RS11030	2220969..2221073	-	105	WP_001802298.1	hypothetical protein	Toxin
HH313_RS11035	2221234..2221717	-	484	Protein_2133	recombinase family protein	-
HH313_RS11040	2221760..2222896	-	1137	Protein_2134	SAP domain-containing protein	-
HH313_RS11045	2223185..2223277	+	93	WP_031844941.1	hypothetical protein	-
HH313_RS11050	2223972..2224829	-	858	WP_000370919.1	Cof-type HAD-IIB family hydrolase	-
HH313_RS11055	2224897..2225679	-	783	WP_000908190.1	ABC transporter ATP-binding protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Sequences

Toxin

Protein

• Length: 35 a.a.
• Molecular weight: 3906.77 Da
• Isoelectric Point: 5.5724

>T155907 WP_001802298.1 NZ_CP053070:c2221073-2220969 [Staphylococcus aureus]
MLLLERTSMSDFEMLMVVLTIIGLVLISTQDHKK

Nucleotide

• Length: 105 bp

>T155907 NZ_CP068819:4391926-4392183 [Escherichia coli]
ATGAATTTATCCCGTCAGGAACAACATACCTTACACGTTCTCGCTAAAGGTAGACGTATTGCGCACGTCCGCGATTCTTC
AGGCCGCGTCACTTCCGTTGAATGCTACAGCCGCGAAGGGCTGTTGCTGACCGACTGCACGCTCGCCGTCTTCAAAAAAC
TCAAAACCAAAAAACTTATCAAGCCCGTCAATGGCCAGCCCTATCGAATCAACACCACCGAGCTGAATAAAGTTCGCGCT
CAGCTCGATAATCGCTAA

Antitoxin

Nucleotide

• Length: 165 bp

>AT155907 NZ_CP053070:2220810-2220974 [Staphylococcus aureus]
GTAGTAAGTAGAAGCAAAAGATGAAAATCTTTAACTCTTGAAACACAAAAAGGGCAACACTCGGAAACATGTTACCCTAA
TGAGCCCGTTAAAAAGACGGTGACCTTATATTTTATTTAAAAATAGCCTTCAAAAATGCCGGTCAAAGCGAATAGAAGGT
TATTT

Structures

Toxin

• AlphaFold DB: A0A2I7Y9L9

Antitoxin