Detailed information of TA system TA155902

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): higBA (relBE)/-
• Location: 1568455..1568869
• Replicon: chromosome
• Accession: NZ_CP053070
• Organism: Staphylococcus aureus strain HL20709 isolate HL20709

Toxin (Protein)

• Gene name: higB
• Uniprot ID: -
• Locus tag: HH313_RS07420
• Protein ID: WP_001065099.1
• Coordinates: 1568618..1568869 (-)
• Length: 84 a.a.

Antitoxin (Protein)

• Gene name: higA
• Uniprot ID: -
• Locus tag: HH313_RS07415
• Protein ID: WP_000028424.1
• Coordinates: 1568455..1568628 (-)
• Length: 58 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HH313_RS07355	1564237..1564581	-	345	WP_000402904.1	hypothetical protein	-
HH313_RS07360	1564712..1565011	-	300	WP_000988330.1	HNH endonuclease	-
HH313_RS07365	1565243..1565659	-	417	WP_000590122.1	hypothetical protein	-
HH313_RS07370	1565687..1565887	-	201	WP_000265043.1	DUF1514 family protein	-
HH313_RS07375	1565887..1566537	-	651	WP_001005262.1	hypothetical protein	-
HH313_RS07380	1566696..1566845	-	150	WP_000237868.1	transcriptional activator RinB	-
HH313_RS07385	1566848..1567048	-	201	WP_001125015.1	hypothetical protein	-
HH313_RS07390	1567023..1567211	-	189	WP_000195782.1	DUF1381 domain-containing protein	-
HH313_RS07395	1567208..1567453	-	246	WP_001282074.1	hypothetical protein	-
HH313_RS07400	1567490..1567996	-	507	WP_001061834.1	dUTPase	-
HH313_RS07405	1568011..1568172	-	162	WP_000889683.1	hypothetical protein	-
HH313_RS07410	1568173..1568454	-	282	WP_000454994.1	hypothetical protein	-
HH313_RS07415	1568455..1568628	-	174	WP_000028424.1	hypothetical protein	Antitoxin
HH313_RS07420	1568618..1568869	-	252	WP_001065099.1	DUF1024 family protein	Toxin
HH313_RS07425	1568884..1569126	-	243	WP_000131388.1	phi PVL orf 51-like protein	-
HH313_RS07430	1569130..1569486	-	357	WP_000029366.1	hypothetical protein	-
HH313_RS07435	1569487..1569672	-	186	WP_001187236.1	DUF3113 family protein	-
HH313_RS07440	1569677..1570081	-	405	WP_000049798.1	DUF1064 domain-containing protein	-
HH313_RS07445	1570091..1570312	-	222	WP_001123669.1	DUF3269 family protein	-
HH313_RS07450	1570325..1570483	-	159	WP_000256594.1	hypothetical protein	-
HH313_RS07455	1570477..1571256	-	780	WP_000803062.1	ATP-binding protein	-
HH313_RS07460	1571266..1572036	-	771	WP_000190254.1	conserved phage C-terminal domain-containing protein	-
HH313_RS07465	1572102..1572383	+	282	WP_000414755.1	hypothetical protein	-
HH313_RS07470	1572376..1572525	-	150	WP_001081076.1	hypothetical protein	-
HH313_RS07475	1572522..1573196	-	675	WP_000057262.1	hypothetical protein	-
HH313_RS07480	1573208..1573651	-	444	WP_001099007.1	single-stranded DNA-binding protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	lukF-PV / lukS-PV	1536900..1600729	63829

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Protein of unknown function DUF1024 (1-82)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 84 a.a.
• Molecular weight: 9376.32 Da
• Isoelectric Point: 3.8364

>T155902 WP_001065099.1 NZ_CP053070:c1568869-1568618 [Staphylococcus aureus]
MNNREQIEQSVISASAYNGNDTEGLLKEIEDVYKKAQAFDEILKGLPNAMQDALKEDIGLDEAVGIMTGQVVYKYEEEQE
NEY

Nucleotide

• Length: 252 bp

>T155902 NZ_CP068819:3313293-3313679 [Escherichia coli]
ATGGGTGTGTATAAGGCAAGACGATTCAGCCAAAGCACGAAAAAACTTGGTATTCACGATAAAGTTCTCATGGCTGCCGC
TGAAGAAGTGATGCAGGGCATATGGGAGGCTGATTTAGGTAGCGGTGTCATCAAAAAACGTTTACCCCTCCAACAAGGAA
AGAGTGGTGGAGCCAGAACAATTATCTTTTTTAAATCAGCAAATCATGTGTTTTTTTATGATGGTTGGTCCAAGAGTGGT
CTAAGCAGTAAAGGAACCAAAGAAATCGAAGATGATGAACTGGCGGCCTACAAAAAAATGGCAAATGCATTTCTGGCCTT
TAGCAATAAGCAAATAGAGGATTTGATCGAAACTGGCTTTTTGATTGAGGTGAAAAATGAGCGATAA

Antitoxin

Protein

• Length: 58 a.a.
• Molecular weight: 6468.29 Da
• Isoelectric Point: 4.2484

>AT155902 WP_000028424.1 NZ_CP053070:c1568628-1568455 [Staphylococcus aureus]
MSISVGDKVYNHETNESLEIVQLVGDIRDTHYKLSDDSVISIIDFITKPIYLIKGDE

Nucleotide

• Length: 174 bp

>AT155902 NZ_CP068819:3313669-3313998 [Escherichia coli]
ATGAGCGATAAATTACAAATGATGCTGGAAGATGCAAAGGAACTGAATGCACTGGGCCTGATGTCTGATAGTGAAGTTGA
TGCCATTGCCGTCATGGTCAAAGCTCGTGAAGTCAGCGCCCGTATAGCCAAAGTCAAATCAATGACGGGTGAAGAGATCA
AAGCCATCCGCACCCGATACGGCATGTCACAATCCGTGCTGGCACATACAATGGGAATGTCAAAAGAAAGTGTCTCGAAA
TGGGAACGTAATGAAATAAAACCGAGCGGCCCGGCATTACGTATTTTGAATACATTGGCAATAAAAGGGCCGGAAGTTTT
TGCAAAGTAA