Detailed information of TA system TA155888

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): hok-sok/-
• Location: 4348199..4348457
• Replicon: chromosome
• Accession: NZ_CP053045
• Organism: Escherichia fergusonii strain HNCF11W

Toxin (Protein)

• Gene name: hokA
• Uniprot ID: F4T5C6
• Locus tag: HG538_RS21000
• Protein ID: WP_001135731.1
• Coordinates: 4348199..4348351 (-)
• Length: 51 a.a.

Antitoxin (RNA)

Gene name	sokA
Locus tag	-
Coordinates	4348402..4348457 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HG538_RS20975	4344064..4344774	-	711	WP_000190514.1	DUF3053 domain-containing protein	-
HG538_RS20980	4345212..4346582	+	1371	WP_000184983.1	MFS transporter	-
HG538_RS20985	4346832..4347122	+	291	WP_000455800.1	HTH-type transcriptional regulator	-
HG538_RS20990	4347404..4347616	+	213	WP_000014594.1	RNA chaperone/antiterminator CspA	-
HG538_RS20995	4347670..4348041	-	372	WP_001037803.1	membrane protein insertion efficiency factor YidD	-
HG538_RS21000	4348199..4348351	-	153	WP_001135731.1	type I toxin-antitoxin system toxin HokA	Toxin
-	4348402..4348457	+	56	-	-	Antitoxin
HG538_RS21005	4348674..4350743	-	2070	WP_001291792.1	glycine--tRNA ligase subunit beta	-
HG538_RS21010	4350753..4351664	-	912	WP_001168544.1	glycine--tRNA ligase subunit alpha	-
HG538_RS21015	4351760..4352059	-	300	WP_024256552.1	YsaB family lipoprotein	-
HG538_RS21020	4352231..4353226	+	996	WP_002432855.1	acyltransferase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Hok/gef cell toxic protein (5-46)

Sequences

Toxin

Protein

• Length: 51 a.a.
• Molecular weight: 6025.30 Da
• Isoelectric Point: 7.7169

>T155888 WP_001135731.1 NZ_CP053045:c4348351-4348199 [Escherichia fergusonii]
MPQKYRLLSLIVICFTLLFFTWMIRDSLCELHIKQENYELAAFLACKLKE

Nucleotide

• Length: 153 bp

>T155888 NZ_CP068819:260168-260275 [Escherichia coli]
ATGACGCTCGCAGAACTGGGCATGGCCTTCTGGCATGATTTAGCGGCTCCGGTCATTGCTGGCATTCTTGCCAGTATGAT
CATGAACTGGCTGAACAAGCGGAAGTAA

Antitoxin

Nucleotide

• Length: 56 bp

>AT155888 NZ_CP053045:4348402-4348457 [Escherichia fergusonii]
GTTGAAGCATAGAGGCAGCCTCACTTTGATTTATAGTCAGGTGGGGCTTTTCTCTG

Structures

Toxin

• AlphaFold DB: A0A061YDD9

Antitoxin