Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) hok-sok/-
Location 996175..996421 Replicon chromosome
Accession NZ_CP053045
Organism Escherichia fergusonii strain HNCF11W

Toxin (Protein)


Gene name hokX Uniprot ID S1PD89
Locus tag HG538_RS04780 Protein ID WP_000956458.1
Coordinates 996269..996421 (+) Length 51 a.a.

Antitoxin (RNA)


Gene name sokX
Locus tag -
Coordinates 996175..996227 (-)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HG538_RS04765 991683..993482 + 1800 WP_105223450.1 NADPH-dependent assimilatory sulfite reductase flavoprotein subunit -
HG538_RS04770 993482..995194 + 1713 WP_001003080.1 assimilatory sulfite reductase (NADPH) hemoprotein subunit -
HG538_RS04775 995268..996002 + 735 WP_000039850.1 phosphoadenosine phosphosulfate reductase -
- 996175..996227 - 53 - - Antitoxin
HG538_RS04780 996269..996421 + 153 WP_000956458.1 type I toxin-antitoxin system Hok family toxin Toxin
HG538_RS04785 996657..999314 + 2658 WP_002431960.1 CRISPR-associated helicase/endonuclease Cas3 -
HG538_RS04790 999412..1000839 + 1428 WP_171881978.1 type I-E CRISPR-associated protein Cse1/CasA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Hok/gef cell toxic protein

(5-46)


Sequences

Toxin        


Download         Length: 51 a.a.        Molecular weight: 5558.77 Da        Isoelectric Point: 7.6757

>T155868 WP_000956458.1 NZ_CP053045:996269-996421 [Escherichia fergusonii]
MLTKYALVAIIVLCCTVLGFTLMVGDSLCELSIRERGMEFKAVLAYESKK

Download         Length: 153 bp

>T155868 NZ_CP068818:2222496-2222599 [Escherichia coli]
GGCAAGGCAACTAAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATAC
AGGAATCGTGTTCGGTCTCTTTTT

Antitoxin


Download         Length: 53 bp

>AT155868 NZ_CP053045:c996227-996175 [Escherichia fergusonii]
TTAGGTTCGAACGCTGGCCTCAGGTTGATAGAAATATCGCCTGGGGCTTTTGT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A4P7TJ83

Antitoxin

Download structure file

References