Detailed information of TA system TA155864

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): hok-sok/-
• Location: 690675..690933
• Replicon: chromosome
• Accession: NZ_CP053045
• Organism: Escherichia fergusonii strain HNCF11W

Toxin (Protein)

• Gene name: hokC
• Uniprot ID: -
• Locus tag: HG538_RS03385
• Protein ID: WP_000935262.1
• Coordinates: 690675..690884 (-)
• Length: 70 a.a.

Antitoxin (RNA)

Gene name	sokC
Locus tag	-
Coordinates	690876..690933 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HG538_RS03365	685741..686328	+	588	WP_002431696.1	molybdopterin adenylyltransferase	-
HG538_RS03370	686362..686928	-	567	WP_000528529.1	acetate uptake transporter	-
HG538_RS03375	687436..689352	+	1917	WP_000516135.1	molecular chaperone DnaK	-
HG538_RS03380	689441..690571	+	1131	WP_001118448.1	molecular chaperone DnaJ	-
HG538_RS03385	690675..690884	-	210	WP_000935262.1	type I toxin-antitoxin system Hok family toxin	Toxin
-	690876..690933	+	58	-	-	Antitoxin
HG538_RS03390	691368..692534	+	1167	WP_000681374.1	Na+/H+ antiporter NhaA	-
HG538_RS03395	692602..693501	+	900	WP_000019049.1	transcriptional activator NhaR	-
HG538_RS03400	693597..693860	-	264	WP_001274021.1	30S ribosomal protein S20	-
HG538_RS03405	693963..694181	+	219	WP_001353471.1	DUF2575 family protein	-
HG538_RS03410	694189..695130	+	942	WP_000767329.1	bifunctional riboflavin kinase/FAD synthetase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Hok/gef cell toxic protein (25-66)

Sequences

Toxin

Protein

• Length: 70 a.a.
• Molecular weight: 7742.28 Da
• Isoelectric Point: 9.3680

>T155864 WP_000935262.1 NZ_CP053045:c690884-690675 [Escherichia fergusonii]
MLNTCRVPLTDRKVKEKRAMKQHKAMIVALIVICITAVVAALVTRKDLCEVHIRTGQTEVAVFTAYESE

Nucleotide

• Length: 210 bp

>T155864 NZ_CP068818:1169965-1170276 [Escherichia coli]
ATGCACATCATTTCGAAAGCGCCATTTGAAGAGTGTGCGCGCAAATATCCTAACGACGCTCTGGCTCTACACTCATTGTA
TCGGGTTATTAAGGAAACGGATTTTTCTACACCAGAAGAAATGCGAACGGCGTTTCCTAACCTCGACAATTTTAAATATC
GCAACAAATGGTACGTTCTGGATGTCGGCGGGAACAATCTTAGGGTTATTGCCTACATAAACTTTGTTAATAAGCGGTTC
TTTGTGAAGCACATAACGAATCACGCAGAGTATGACAAACTGACACGTTACTACAGAGAGAACAAAGAATGA

Antitoxin

Nucleotide

• Length: 58 bp

>AT155864 NZ_CP053045:690876-690933 [Escherichia fergusonii]
GTTCAGCATATAGGGGGCCTCGGGTTGATGGTAAAATATCACTCGGGGCTTTTCTCTA

Structures

Antitoxin