Detailed information of TA system TA155859

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): prlF-yhaV (relBE)/YhaV-PrlF
• Location: 474797..475612
• Replicon: chromosome
• Accession: NZ_CP053044
• Organism: Proteus terrae subsp. cibarius strain HNCF43W

Toxin (Protein)

• Gene name: yhaV
• Uniprot ID: -
• Locus tag: HG541_RS02080
• Protein ID: WP_075673429.1
• Coordinates: 474797..475270 (-)
• Length: 158 a.a.

Antitoxin (Protein)

• Gene name: prlF
• Uniprot ID: -
• Locus tag: HG541_RS02085
• Protein ID: WP_075673430.1
• Coordinates: 475277..475612 (-)
• Length: 112 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HG541_RS02065	470619..472814	-	2196	WP_099659727.1	flotillin family protein	-
HG541_RS02070	472901..473536	-	636	WP_156734149.1	DUF1449 family protein	-
HG541_RS02075	473839..474486	-	648	WP_075673428.1	CPBP family intramembrane metalloprotease	-
HG541_RS02080	474797..475270	-	474	WP_075673429.1	type II toxin-antitoxin system YhaV family toxin	Toxin
HG541_RS02085	475277..475612	-	336	WP_075673430.1	type II toxin-antitoxin system PrlF family antitoxin	Antitoxin
HG541_RS02095	476259..476831	-	573	WP_075673431.1	transcriptional regulator	-
HG541_RS02100	477015..478340	-	1326	WP_036934359.1	anaerobic C4-dicarboxylate transporter	-
HG541_RS02105	478499..479923	-	1425	WP_072069056.1	aspartate ammonia-lyase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin endonuclease, YhaV (12-147)

Antitoxin

• PrlF antitoxin (15-109)

Sequences

Toxin

Protein

• Length: 158 a.a.
• Molecular weight: 18639.26 Da
• Isoelectric Point: 9.2715

>T155859 WP_075673429.1 NZ_CP053044:c475270-474797 [Proteus terrae subsp. cibarius]
MDFPTDLNGWTIYAHPCFKQQYDELLQKVEALKKKYPEDYQKKADTKIFAHVLKSIVNITNDPRAPEFRLGNTLGEENKN
WSRIKLVNGRYRLFFRFSFKEKIIILAWINDNDTLRTYGNKTDAYRVFEKKLKKGHPPKNWNDLFSDCINEADCQDP

Nucleotide

• Length: 474 bp

>T155859 NZ_CP068818:261475-261582 [Escherichia coli]
ATGACGCTCGCAGAGCTGGGCATGGCCTTCTGGCATGATTTAGCGGCTCCGGTCATTGCTGGCATTCTTGCCAGTCTGAT
CGTGAACTGGCTGAACAAGCGGAAGTAA

Antitoxin

Protein

• Length: 112 a.a.
• Molecular weight: 12312.67 Da
• Isoelectric Point: 4.2560

>AT155859 WP_075673430.1 NZ_CP053044:c475612-475277 [Proteus terrae subsp. cibarius]
MLTHVCTDNIALEADSKITERHQTTIPASIREALHLSGGDRIHYKLLSTGDVLISRHSDGSEDPVMASFLNFLAQDITNH
PQTIQPLDISRGFELVEGMDINLDDDITDNE

Nucleotide

• Length: 336 bp

>AT155859 NZ_CP068818:c261426-261363 [Escherichia coli]
GTCTAGATGCAAGAATGGCCCCCGTGGTGTTGTCAGGTGCATACCTGCAACGTGCGGGGGTTTT