Detailed information of TA system TA155851

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): yefM-yoeB (relBE)/YoeB-YefM
• Location: 2141416..2141918
• Replicon: chromosome
• Accession: NZ_CP053042
• Organism: Proteus terrae subsp. cibarius strain HNCF44W

Toxin (Protein)

• Gene name: yoeB
• Uniprot ID: -
• Locus tag: HG539_RS09920
• Protein ID: WP_075671248.1
• Coordinates: 2141416..2141670 (-)
• Length: 85 a.a.

Antitoxin (Protein)

• Gene name: yefM
• Uniprot ID: -
• Locus tag: HG539_RS09925
• Protein ID: WP_072068851.1
• Coordinates: 2141667..2141918 (-)
• Length: 84 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HG539_RS09895	2136750..2137247	-	498	WP_075671238.1	Der GTPase-activating protein YihI	-
HG539_RS09900	2137436..2138908	+	1473	WP_075671240.1	glycosyltransferase family 39 protein	-
HG539_RS09905	2138911..2139459	+	549	WP_075671242.1	GNAT family N-acetyltransferase	-
HG539_RS09910	2139509..2139820	-	312	WP_075671244.1	monooxygenase	-
HG539_RS09915	2139901..2141259	-	1359	WP_075671246.1	NCS2 family permease	-
HG539_RS09920	2141416..2141670	-	255	WP_075671248.1	Txe/YoeB family addiction module toxin	Toxin
HG539_RS09925	2141667..2141918	-	252	WP_072068851.1	YoeB-YefM toxin-antitoxin system antitoxin YefM	Antitoxin
HG539_RS09930	2142149..2142901	-	753	WP_159242128.1	amino acid ABC transporter permease	-
HG539_RS09935	2142903..2143640	-	738	WP_075671252.1	amino acid ABC transporter permease	-
HG539_RS09940	2143747..2144586	-	840	WP_036933789.1	ABC transporter substrate-binding protein	-
HG539_RS09945	2144802..2145536	-	735	WP_075671254.1	phosphate signaling complex protein PhoU	-
HG539_RS09950	2145551..2146327	-	777	WP_006534565.1	phosphate ABC transporter ATP-binding protein PstB	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin YoeB (5-84)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-73)

Sequences

Toxin

Protein

• Length: 85 a.a.
• Molecular weight: 10170.78 Da
• Isoelectric Point: 9.9411

>T155851 WP_075671248.1 NZ_CP053042:c2141670-2141416 [Proteus terrae subsp. cibarius]
MKLIFSEQSWSDYLYWQQIDKKIIKRINELIKDIKRTPFSGIGKPEPLKHNLAGFWSRRITDEHRLIYRITDSAIEIASC
RYHY

Nucleotide

• Length: 255 bp

>T155851 NZ_CP068817:4271958-4272110 [Escherichia coli]
ATGAAGCAGCATAAGGCGATGATTGTCGCCCTGATCGTCATCTGTATCACCGCCGTAGTGGCGGCGCTGGTAACGAGAAA
AGACCTCTGTGAGGTTCACATCCGAACTGGCCAGACGGAGGTTGCTGTTTTCACGGCTTACGAATCCGAGTAA

Antitoxin

Protein

• Length: 84 a.a.
• Molecular weight: 9463.77 Da
• Isoelectric Point: 4.4354

>AT155851 WP_072068851.1 NZ_CP053042:c2141918-2141667 [Proteus terrae subsp. cibarius]
MKTINYTEARQNLTSIMNETIDDRVPIMITRQKGIPCVLLSLDEYQALEETAYLLRSPANARHLLDSIDELNQGKGIEKD
ITE

Nucleotide

• Length: 252 bp

>AT155851 NZ_CP068817:c4271909-4271852 [Escherichia coli]
GTTCTGCATATAGGGGGCCTCGGGTTGATGGTAAAATATCACTCGGGGCTTTTCTCTA