Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/-
Location 658250..658905 Replicon chromosome
Accession NZ_CP053032
Organism Halomonas sp. PGE1

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag HIR79_RS03160 Protein ID WP_169956724.1
Coordinates 658567..658905 (-) Length 113 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag HIR79_RS03155 Protein ID WP_169956722.1
Coordinates 658250..658564 (-) Length 105 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HIR79_RS03135 653409..654359 + 951 WP_169956715.1 TIGR03756 family integrating conjugative element protein -
HIR79_RS03140 654373..655857 + 1485 WP_169956717.1 integrating conjugative element protein -
HIR79_RS03145 655857..656249 + 393 WP_169956718.1 hypothetical protein -
HIR79_RS03150 656249..657778 + 1530 WP_169956720.1 conjugal transfer protein TraG N-terminal domain-containing protein -
HIR79_RS03155 658250..658564 - 315 WP_169956722.1 transcriptional regulator Antitoxin
HIR79_RS03160 658567..658905 - 339 WP_169956724.1 toxin Toxin
HIR79_RS03165 659306..659569 + 264 WP_169956726.1 DUF4236 domain-containing protein -
HIR79_RS03170 659945..660622 + 678 WP_169956728.1 restriction endonuclease subunit S -
HIR79_RS03175 660638..662185 + 1548 WP_169956730.1 type I restriction-modification system subunit M -
HIR79_RS03180 662175..663263 + 1089 WP_169956732.1 DUF1016 family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - - 617889..716687 98798


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Cro/C1-type helix-turn-helix domain

(41-100)


Sequences

Toxin        


Download         Length: 113 a.a.        Molecular weight: 13131.98 Da        Isoelectric Point: 10.3953

>T155822 WP_169956724.1 NZ_CP053032:c658905-658567 [Halomonas sp. PGE1]
MKAIFVELPAFERHRSSYFDDAEFRAFQNLLLKNPTAGDVIQGTGGLRKVRFSDPKRQKGKRSGVRIIYYWWLNGSQFWL
FTLYDKDAQDDLTPAQRKTLRQMLDAEINART

Download         Length: 339 bp

>T155822 NZ_CP068816:c3642816-3642514 [Escherichia coli]
ATGGCTCAAAAGAAAAATATAAGGAGTTTTCGTGATGCCTGGTTGGCTGATTTTTTTGTCCATTCAACGCCACATCGAAA
GATCCCTGCTGAAATCCATACCACGTTATCACGAAAGTTGGACATCATTAATGCTGCCACTTCTCATCGGGATTTACGCT
CCCCTCCGGGGAACCGATACGAAGAGTTATCCGGGAAATTACAGGAATACTCCTCCATTAGAGTGAATAAACAGTACCGA
CTGATTTTTAAATGGGTTAATGGCAAGGCCGAAGAATTGTTTTTAGACCCACACAACTACTAA

Antitoxin


Download         Length: 105 a.a.        Molecular weight: 11997.69 Da        Isoelectric Point: 6.2359

>AT155822 WP_169956722.1 NZ_CP053032:c658564-658250 [Halomonas sp. PGE1]
MDRNIFDELVEGFDALAEERQGKRTLRSHPVALDEVPDVTADELIALREKLHMSRPVFAMYLRTNPRTLENWEQGRAKPN
AQAKTLIRLVQKYPETIEHLASLS

Download         Length: 315 bp

>AT155822 NZ_CP068816:c3642478-3642137 [Escherichia coli]
ATGAAACAGGCAACAAGAAAACCGACGACACCCGGAGATATTCTTCTCTATGAATATCTGGAACCGCTCGATTTGAAAAT
CAATGAGTTAGCAGAGTTGCTGCATGTTCATCGTAATAGCGTCAGTGCACTGATCAATAACAATCGTAAACTCACCACTG
AGATGGCATTCCGTCTGGCGAAAGTTTTTGATACCACAGTCGATTTTTGGCTAAACCTCCAGGCGGCAGTTGATCTTTGG
GAAGTTGAAAACAACATGCGTACCCAGGAAGAATTGGGACGGATTGAAACAGTGGCTGAATATTTGGCACGTCGTGAAGA
GCGTGCAAAAAAGGTCGCGTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References