Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HTH(antitoxin)
Location 631777..632379 Replicon chromosome
Accession NZ_CP052870
Organism Enterobacter cloacae strain 3849

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag HJI43_RS03075 Protein ID WP_045308723.1
Coordinates 632068..632379 (-) Length 104 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag HJI43_RS03070 Protein ID WP_032626927.1
Coordinates 631777..632067 (-) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HJI43_RS03055 629275..630177 + 903 WP_003861960.1 formate dehydrogenase subunit beta -
HJI43_RS03060 630174..630809 + 636 WP_006808711.1 formate dehydrogenase cytochrome b556 subunit -
HJI43_RS03065 630806..631735 + 930 WP_022649835.1 formate dehydrogenase accessory protein FdhE -
HJI43_RS03070 631777..632067 - 291 WP_032626927.1 helix-turn-helix domain-containing protein Antitoxin
HJI43_RS03075 632068..632379 - 312 WP_045308723.1 toxin HigB-2 Toxin
HJI43_RS03080 632528..633469 - 942 WP_022649838.1 fatty acid biosynthesis protein FabY -
HJI43_RS03085 633514..633951 - 438 WP_048965998.1 D-tyrosyl-tRNA(Tyr) deacylase -
HJI43_RS03090 633948..634829 - 882 WP_023298923.1 virulence factor BrkB family protein -
HJI43_RS03095 634823..635422 - 600 WP_003861947.1 glucose-1-phosphatase -
HJI43_RS03100 635541..636341 - 801 WP_048965999.1 DeoR/GlpR family DNA-binding transcription regulator -
HJI43_RS03105 636376..637272 - 897 WP_048966000.1 sugar kinase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Cro/C1-type helix-turn-helix domain

(36-85)


Sequences

Toxin        


Download         Length: 104 a.a.        Molecular weight: 12134.10 Da        Isoelectric Point: 9.4455

>T155676 WP_045308723.1 NZ_CP052870:c632379-632068 [Enterobacter cloacae]
MLFIETDIFTEDVKTLLDDDEYHRFQIFLATQPDYGDLIQNSGGLRKIRWLAGGKGKRSGVRVIYFHRTRECEIRLLLIY
RKGIKDDLSAGEKAILKKMIERW

Download         Length: 312 bp

>T155676 NZ_CP068811:1952826-1953080 [Escherichia coli]
GTGAAACTAATCTGGTCTGAGGAGTCATGGGATGATTATCTGTACTGGCAGGAAACAGATAAGCGAATTGTTAAAAAGAT
CAATGAACTTATCAAAGATACCCGCAGAACACCATTTGAAGGTAAGGGGAAGCCAGAACCCCTGAAACATAATTTGTCAG
GTTTCTGGTCCCGACGCATTACAGAGGAGCACCGTCTGGTATACGCGGTTACCGACGATTCACTGCTCATTGCAGCATGT
CGTTATCATTATTGA

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10685.18 Da        Isoelectric Point: 10.5888

>AT155676 WP_032626927.1 NZ_CP052870:c632067-631777 [Enterobacter cloacae]
MDKALFERLTQSIAQINEIAEGQREPSRTFQIDAMKIKEIRQASGLSQSKFANLISVSVDTLRNWEQGRRSPTGPAKALL
RAIANDPQHVIPALSQ

Download         Length: 291 bp

>AT155676 NZ_CP068811:1952578-1952829 [Escherichia coli]
ATGCGTACAATTAGCTACAGCGAAGCGCGTCAGAATTTGTCGGCAACAATGATGAAAGCCGTTGAAGATCATGCCCCGAT
CCTTATTACTCGTCAGAATGGAGAGGCTTGTGTTCTGATGTCACTCGAAGAATACAACTCGCTGGAAGAGACGGCTTATC
TACTGCGCTCCCCCGCTAACGCCCGGAGATTGATGGACTCAATCGATAGCCTGAAATCAGGCAAAGGAACGGAAAAGGAC
ATTATTGAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References