Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/-
Location 4571737..4572392 Replicon chromosome
Accession NZ_CP052857
Organism Pseudomonas sp. ADAK21

Toxin (Protein)


Gene name higB Uniprot ID A0A1S1UXS8
Locus tag HKK57_RS20740 Protein ID WP_070995472.1
Coordinates 4572048..4572392 (-) Length 115 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID A0A1S1UVI2
Locus tag HKK57_RS20735 Protein ID WP_070995473.1
Coordinates 4571737..4572051 (-) Length 105 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HKK57_RS20715 4567794..4568660 + 867 WP_029293322.1 sugar ABC transporter permease -
HKK57_RS20720 4568671..4569471 + 801 WP_017735079.1 carbohydrate ABC transporter permease -
HKK57_RS20725 4569482..4569754 + 273 WP_029293327.1 DUF2160 domain-containing protein -
HKK57_RS20730 4569921..4571663 + 1743 WP_029293329.1 ABC transporter substrate-binding protein -
HKK57_RS20735 4571737..4572051 - 315 WP_070995473.1 transcriptional regulator Antitoxin
HKK57_RS20740 4572048..4572392 - 345 WP_070995472.1 toxin Toxin
HKK57_RS20745 4572631..4574094 - 1464 WP_029293335.1 NADH-quinone oxidoreductase subunit NuoN -
HKK57_RS20750 4574102..4575634 - 1533 WP_029293337.1 NADH-quinone oxidoreductase subunit M -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Cro/C1-type helix-turn-helix domain

(41-100)


Sequences

Toxin        


Download         Length: 115 a.a.        Molecular weight: 13470.41 Da        Isoelectric Point: 9.9080

>T155641 WP_070995472.1 NZ_CP052857:c4572392-4572048 [Pseudomonas sp. ADAK21]
MDALFIELPPFERYRKDYLTDELFHGFQQELMKNPEAGAVMEGTGGLRKLRFVDERRNKGKRGGLRVIYYWWSGGTQFWL
FTLYGKHEQSDLSPQHKKALKQLLDREINARGFT

Download         Length: 345 bp

>T155641 NZ_CP068810:217664-217771 [Escherichia coli]
ATGACGCTCGCAGAACTGGGCATGGCCTTCTGGCATGATTTAGCGGCTCCGGTCATTGCTGGCATTCTTGCCAGTATGAT
CATGAACTGGCTGAACAAGCGGAAGTAA

Antitoxin


Download         Length: 105 a.a.        Molecular weight: 11838.58 Da        Isoelectric Point: 10.5386

>AT155641 WP_070995473.1 NZ_CP052857:c4572051-4571737 [Pseudomonas sp. ADAK21]
MKRDIYSELVEGFDALANERQGKVTLRTHTVQQNKLAPLTAEDVIAVRQQLNLSRAVFAMYLRTNTRTLENWEQGRARPN
AQAATLIRLVSKFPDTVERLALLS

Download         Length: 315 bp

>AT155641 NZ_CP068810:c217615-217552 [Escherichia coli]
GTCTAGAGTCAAGATTAGCCCCCGTGGTGTTGTCAGGTGCATACCTGCAACGTGCGGGGGTTTT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1S1UXS8

Antitoxin

Source ID Structure
AlphaFold DB A0A1S1UVI2

References