Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 234401..234968 Replicon chromosome
Accession NZ_CP052854
Organism Xylella fastidiosa subsp. multiplex strain LM10

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag HKJ32_RS00975 Protein ID WP_004085174.1
Coordinates 234687..234968 (-) Length 94 a.a.

Antitoxin (Protein)


Gene name graA Uniprot ID -
Locus tag HKJ32_RS00970 Protein ID WP_004085172.1
Coordinates 234401..234676 (-) Length 92 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HKJ32_RS00940 230295..232169 + 1875 WP_169709907.1 phage major capsid protein -
HKJ32_RS00945 232187..232447 + 261 WP_012337650.1 hypothetical protein -
HKJ32_RS00950 232447..232770 + 324 WP_169709908.1 hypothetical protein -
HKJ32_RS00955 232767..233294 + 528 WP_169709909.1 hypothetical protein -
HKJ32_RS00960 233270..233812 + 543 WP_154436958.1 hypothetical protein -
HKJ32_RS00965 233809..234396 + 588 WP_042836490.1 phage baseplate assembly protein V -
HKJ32_RS00970 234401..234676 - 276 WP_004085172.1 HigA family addiction module antidote protein Antitoxin
HKJ32_RS00975 234687..234968 - 282 WP_004085174.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
HKJ32_RS00980 235166..235504 + 339 WP_004088650.1 GPW/gp25 family protein -
HKJ32_RS00985 235504..236397 + 894 WP_038284057.1 baseplate J/gp47 family protein -
HKJ32_RS00990 236390..236947 + 558 WP_169709910.1 phage tail protein I -
HKJ32_RS00995 236955..238547 + 1593 WP_169709911.1 tail fiber domain-containing protein -
HKJ32_RS01000 238612..239790 + 1179 WP_038230457.1 phage tail sheath family protein -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 201218..247924 46706


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(3-93)

Antitoxin

(15-64)


Sequences


Toxin        


Download         Length: 94 a.a.        Molecular weight: 10610.17 Da        Isoelectric Point: 9.8829

>T155619 WP_004085174.1 NZ_CP052854:c234968-234687 [Xylella fastidiosa subsp. multiplex]
MIKSFRHKGIQQFFLVGSTAGIQTKHAAKLRIQLTALESAKRPEDMNAPGWKLHPLKGADLKGHWSIWVNGNYRLTFAFE
GEDAILVDYQDYH

Download         Length: 282 bp

>T155619 NZ_CP068809:1929689-1929940 [Escherichia coli]
ATGCGTACAATTAGCTACAGCGAAGCGCGTCAGAATTTGTCGGCAACAATGATGAAAGCCGTTGAAGATCATGCCCCGAT
CCTCATTACTCGTCAGAATGGAGAGGCTTGTGTTCTGATGTCACTCGAAGAATACAACTCGCTGGAAGAGACGGCTTATC
TACTGCGTTCCCCCGCTAACGCCCGGAGATTGATGGACTCAATCGATAGCCTGAAATCAGGCAAAGGAACGGAAAAGGAC
ATTATTGAGTGA

Antitoxin


Download         Length: 92 a.a.        Molecular weight: 10072.68 Da        Isoelectric Point: 10.2184

>AT155619 WP_004085172.1 NZ_CP052854:c234676-234401 [Xylella fastidiosa subsp. multiplex]
MKRMHNPAHPGEVLREYLGELTVTNAAAKLGVSRVALSRILNGTNGISADMALRLEDALGTSAEMWAAMQFKYDLWVASQ
QPRPKITRLHV

Download         Length: 276 bp

>AT155619 NZ_CP068809:1929937-1930191 [Escherichia coli]
GTGAAACTAATCTGGTCTGAGGAATCATGGGATGATTATCTGTACTGGCAGGAAACAGATAAGCGAATTGTTAAAAAGAT
CAATGAAATTATCAAAGATACACGCAGAACACCATTTGAAGGTAAGGGGAAGCCAGAACCCCTGAAACATAATTTGTCAG
GCTTCTGGTCCCGACGCATTACAGAGGAGCACCGTCTGGTATACGCGGTTACCGACGATTCACTGCTCATTGCAGCATGT
CGTTATCATTATTGA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure


Antitoxin

Source ID Structure

References