Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 234379..234946 Replicon chromosome
Accession NZ_CP052853
Organism Xylella fastidiosa subsp. multiplex strain RH1

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag HKJ33_RS00985 Protein ID WP_004085174.1
Coordinates 234665..234946 (-) Length 94 a.a.

Antitoxin (Protein)


Gene name graA Uniprot ID -
Locus tag HKJ33_RS00980 Protein ID WP_004085172.1
Coordinates 234379..234654 (-) Length 92 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HKJ33_RS00950 230273..232147 + 1875 WP_169709907.1 phage major capsid protein -
HKJ33_RS00955 232165..232425 + 261 WP_012337650.1 hypothetical protein -
HKJ33_RS00960 232425..232748 + 324 WP_169709908.1 hypothetical protein -
HKJ33_RS00965 232745..233272 + 528 WP_169709909.1 hypothetical protein -
HKJ33_RS00970 233248..233790 + 543 WP_154436958.1 hypothetical protein -
HKJ33_RS00975 233787..234374 + 588 WP_042836490.1 phage baseplate assembly protein V -
HKJ33_RS00980 234379..234654 - 276 WP_004085172.1 HigA family addiction module antidote protein Antitoxin
HKJ33_RS00985 234665..234946 - 282 WP_004085174.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
HKJ33_RS00990 235144..235482 + 339 WP_004088650.1 GPW/gp25 family protein -
HKJ33_RS00995 235482..236375 + 894 WP_038284057.1 baseplate J/gp47 family protein -
HKJ33_RS01000 236368..236925 + 558 WP_169709910.1 phage tail protein I -
HKJ33_RS01005 236933..238525 + 1593 WP_169709911.1 tail fiber domain-containing protein -
HKJ33_RS01010 238590..239768 + 1179 WP_038230457.1 phage tail sheath family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 204628..247902 43274


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(3-93)

Antitoxin

Cro/C1-type helix-turn-helix domain

(15-64)


Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 10610.17 Da        Isoelectric Point: 9.8829

>T155610 WP_004085174.1 NZ_CP052853:c234946-234665 [Xylella fastidiosa subsp. multiplex]
MIKSFRHKGIQQFFLVGSTAGIQTKHAAKLRIQLTALESAKRPEDMNAPGWKLHPLKGADLKGHWSIWVNGNYRLTFAFE
GEDAILVDYQDYH

Download         Length: 282 bp

>T155610 NZ_CP068808:c4617477-4617127 [Escherichia coli]
ATGGTAAAGAAAAGTGAATTTGAACGGGGAGACATTGTGCTGGTTGGCTTTGATCCAGCAAGCGGCCATGAACAGCAAGG
TGCTGGTCGACCTGCGCTTGTGCTCTCCGTTCAAGCCTTTAATCAACTGGGAATGACGCTGGTGGCCCCCATTACGCAGG
GCGGAAATTTTGCCCGTTATGCCGGATTTAGCGTTCCTTTACATTGCGAAGAAGGCGATGTGCACGGCGTGGTGCTGGTG
AATCAGGTGTGGATGATGGATCTACGCGCCCGGCTGGCAAAGCGTATTGGTCTGGCTGCGGGTGAGGTGGTGGAAGAGGC
GTTATTACGTTTGCAGGCGGTGGTGGAATAA

Antitoxin


Download         Length: 92 a.a.        Molecular weight: 10072.68 Da        Isoelectric Point: 10.2184

>AT155610 WP_004085172.1 NZ_CP052853:c234654-234379 [Xylella fastidiosa subsp. multiplex]
MKRMHNPAHPGEVLREYLGELTVTNAAAKLGVSRVALSRILNGTNGISADMALRLEDALGTSAEMWAAMQFKYDLWVASQ
QPRPKITRLHV

Download         Length: 276 bp

>AT155610 NZ_CP068808:c4617722-4617471 [Escherichia coli]
ATGCGTATTACCATAAAAAGATGGGGGAACAGTTCAGGTATGGTCATTCCTAATGTTGTGATGAAAGAACTTAACTTACG
GCCGGGGCAGAGCGTGGAGGCGCAAGTGAGCAACAATCAACTGATTCTGACACCCATCTCCAGGCGCTACTCGCTTGATG
AACTGCTGGCACAGTGTGACATGAACGCCACGGAACTTAGCGAGCAGGATGTCTGGGGTAAATCCACCCCTGCGGGTGAC
GAAATATGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References