Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/MqsA(antitoxin)
Location 101032..101684 Replicon plasmid Plas1
Accession NZ_CP052109
Organism Ralstonia solanacearum strain FJAT15249.F1

Toxin (Protein)


Gene name higB Uniprot ID A0A454TTN3
Locus tag HI803_RS19405 Protein ID WP_038962847.1
Coordinates 101032..101376 (+) Length 115 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag HI803_RS19410 Protein ID WP_020425351.1
Coordinates 101373..101684 (+) Length 104 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HI803_RS19390 96728..97891 - 1164 WP_016725329.1 2-methylcitrate synthase -
HI803_RS19395 97943..98839 - 897 WP_038962849.1 methylisocitrate lyase -
HI803_RS19400 99032..100981 + 1950 WP_023470006.1 propionate catabolism operon regulatory protein PrpR -
HI803_RS19405 101032..101376 + 345 WP_038962847.1 hypothetical protein Toxin
HI803_RS19410 101373..101684 + 312 WP_020425351.1 transcriptional regulator Antitoxin
HI803_RS19415 101824..102633 - 810 WP_043885575.1 DUF2242 domain-containing protein -
HI803_RS19420 104025..105011 - 987 WP_016721870.1 IS5 family transposase -
HI803_RS19425 105067..106392 + 1326 WP_016725321.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - cyaB / flgC / flgG / fliM / fliG / fliI / acrB / adeG / cheY / cheB / cheW / motA 1..2075656 2075656


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Cro/C1-type helix-turn-helix domain

(41-91)


Sequences

Toxin        


Download         Length: 115 a.a.        Molecular weight: 13227.94 Da        Isoelectric Point: 8.4489

>T155505 WP_038962847.1 NZ_CP052109:101032-101376 [Ralstonia solanacearum]
MDATFIELPPFQRLREHYLSDDEYRALQQELLARPDAGDVIKGTGGLRKLRFSDKRRGKGKRGGLRVIDYHWDGGGQFWM
FVVYDKGEADDLSSDERKVLARLLEQEVKARSER

Download         Length: 345 bp

>T155505 NZ_CP068805:258451-258558 [Escherichia coli]
ATGACGCTCGCAGAGCTGGGCATGGCCTTCTGGCATGATTTAGCGGCTCCGGTCATTGCTGGCATTCTTGCCAGTCTGAT
CGTGAACTGGCTGAACAAGCGGAAGTAA

Antitoxin


Download         Length: 104 a.a.        Molecular weight: 11619.65 Da        Isoelectric Point: 10.7132

>AT155505 WP_020425351.1 NZ_CP052109:101373-101684 [Ralstonia solanacearum]
MKRNLFAELKEGMDALAAEREGKMTLRKVKVRVLQPLDVTAEEIKAVRAAAHASQAVMARRLRVNVRTYQNWEQGTAKPN
TQAAVLIKLVEKHPETLQMLEAL

Download         Length: 312 bp

>AT155505 NZ_CP068805:c258393-258339 [Escherichia coli]
CAAGAATGGCCCCCGTGGTGTTGTCAGGTGCATACCTGCAACGTGCGGGGGTTTT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A454TTN3

Antitoxin

Source ID Structure

References