Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/MqsA(antitoxin)
Location 85985..86637 Replicon plasmid Plas1
Accession NZ_CP052093
Organism Ralstonia solanacearum strain FJAT15340.F50

Toxin (Protein)


Gene name higB Uniprot ID A0A0S4U5H4
Locus tag HI811_RS17410 Protein ID WP_028861315.1
Coordinates 85985..86329 (+) Length 115 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag HI811_RS17415 Protein ID WP_020425351.1
Coordinates 86326..86637 (+) Length 104 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HI811_RS17395 81681..82844 - 1164 WP_016726526.1 2-methylcitrate synthase -
HI811_RS17400 82896..83792 - 897 WP_071092368.1 methylisocitrate lyase -
HI811_RS17405 83985..85934 + 1950 WP_023470006.1 propionate catabolism operon regulatory protein PrpR -
HI811_RS17410 85985..86329 + 345 WP_028861315.1 hypothetical protein Toxin
HI811_RS17415 86326..86637 + 312 WP_020425351.1 transcriptional regulator Antitoxin
HI811_RS17420 86777..87586 - 810 WP_071623829.1 DUF2242 domain-containing protein -
HI811_RS17425 88230..88805 - 576 WP_071623824.1 hypothetical protein -
HI811_RS17430 89218..91065 + 1848 WP_071623825.1 AAA family ATPase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - cyaB / flgC / flgG / fliM / fliG / fliI / acrB / adeG / cheY / cheB / cheW / motA 1..2053891 2053891


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Cro/C1-type helix-turn-helix domain

(41-91)


Sequences

Toxin        


Download         Length: 115 a.a.        Molecular weight: 13276.03 Da        Isoelectric Point: 9.3395

>T155469 WP_028861315.1 NZ_CP052093:85985-86329 [Ralstonia solanacearum]
MDATFIELPPFQRLREHYLSDDEYRALQQELLARPDAGDVIKGTGGLRKLRFSDKRRGKGKRGGLRVIYYHWDGGGQFWM
FVVYDKGEADDLSSDERKVLARLLEQEVKARSER

Download         Length: 345 bp

>T155469 NZ_CP068803:2719440-2719547 [Escherichia coli]
ATGACGCTCGCGCAGTTTGCCATGATTTTCTGGCACGACCTGGCAGCACCGATCCTGGCGGGAATTATTACCGCAGCGAT
TGTCGGCTGGTGGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 104 a.a.        Molecular weight: 11619.65 Da        Isoelectric Point: 10.7132

>AT155469 WP_020425351.1 NZ_CP052093:86326-86637 [Ralstonia solanacearum]
MKRNLFAELKEGMDALAAEREGKMTLRKVKVRVLQPLDVTAEEIKAVRAAAHASQAVMARRLRVNVRTYQNWEQGTAKPN
TQAAVLIKLVEKHPETLQMLEAL

Download         Length: 312 bp

>AT155469 NZ_CP068803:c2719390-2719327 [Escherichia coli]
TCTGGTTCAAGATTAGCCCCCGTTCTGTTGTCAGGTTAAACCTCTCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0S4U5H4

Antitoxin

Source ID Structure

References