Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) DinJ-YafQ (relBE)/YafQ-DinJ
Location 1378291..1378855 Replicon chromosome
Accession NZ_CP052065
Organism Lacticaseibacillus paracasei strain 347-16

Toxin (Protein)


Gene name yafQ Uniprot ID A0A510WIJ9
Locus tag GJS60_RS07190 Protein ID WP_016363448.1
Coordinates 1378553..1378855 (+) Length 101 a.a.

Antitoxin (Protein)


Gene name dinJ Uniprot ID K6SLT0
Locus tag GJS60_RS07185 Protein ID WP_003570051.1
Coordinates 1378291..1378560 (+) Length 90 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GJS60_RS07155 1373296..1374183 - 888 WP_003570041.1 ABC transporter ATP-binding protein -
GJS60_RS07160 1374380..1375606 - 1227 WP_003570043.1 hypothetical protein -
GJS60_RS07165 1375804..1376208 + 405 WP_003570045.1 MerR family transcriptional regulator -
GJS60_RS07170 1376201..1376527 + 327 WP_003584272.1 YrdB family protein -
GJS60_RS07175 1376590..1377219 + 630 WP_003570047.1 DUF2399 domain-containing protein -
GJS60_RS07180 1377264..1377917 + 654 WP_003570049.1 GNAT family N-acetyltransferase -
GJS60_RS07185 1378291..1378560 + 270 WP_003570051.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
GJS60_RS07190 1378553..1378855 + 303 WP_016363448.1 type II toxin-antitoxin system YafQ family toxin Toxin
GJS60_RS07195 1379194..1379337 + 144 WP_162259784.1 hypothetical protein -
GJS60_RS07200 1379455..1380147 + 693 WP_003570055.1 hypothetical protein -
GJS60_RS07205 1380383..1382560 + 2178 WP_003570057.1 RNA-binding transcriptional accessory protein -
GJS60_RS07210 1382985..1383542 - 558 WP_003584278.1 helix-turn-helix domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, YafQ-like toxin

(3-97)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(10-70)


Sequences

Toxin        


Download         Length: 101 a.a.        Molecular weight: 11510.33 Da        Isoelectric Point: 9.8881

>T155420 WP_016363448.1 NZ_CP052065:1378553-1378855 [Lacticaseibacillus paracasei]
MYSLVPTPTFKRDLKRLSKKHWPMDELKTAVNLLAAGTNAELLSKKYADHALSSSSEWKGYRELYVDGPRGDWLLIYKIE
QQDLILTLVRTGSHHNLLVK

Download         Length: 303 bp

>T155420 NZ_CP068801:c2690519-2690343 [Escherichia coli]
GTGAAACAAAGCGAGTTCAGACGTTGGCTCGAATCTCAGGGCGTCGATGTAGCGAATGGCAGCAACCATTTAAAACTCAG
GTTTCACGGGAGGCGCAGTGTCATGCCGCGTCACCCCAGCGAAGAGATTAAAGAACCATTGCGTAAAGCCATTCTGAAAC
AACTCGGTTTGAGTTAA

Antitoxin


Download         Length: 90 a.a.        Molecular weight: 9982.68 Da        Isoelectric Point: 7.2026

>AT155420 WP_003570051.1 NZ_CP052065:1378291-1378560 [Lacticaseibacillus paracasei]
MAATKKETRLNIRVDPELKSAAQIVANDMGIDLTAAVTMFMTKMVKDHALPFTPTSLPVETLQALKEAKHPELLKKYSTP
DDMWRDLNV

Download         Length: 270 bp

>AT155420 NZ_CP068801:c2690297-2689881 [Escherichia coli]
ATGCGTTATCCCGTCACTCTTACACCCGCGCCGGAAGGCGGTTATATGGTTTCTTTTGTGGATATCCCTGAAGCGTTGAC
CCAGGGCGAAACTGTCGCTGAAGCGATGGAAGCGGCAAAAGATGCTTTACTGACCGCATTTGATTTTTATTTTGAAGATA
ACGAGCTTATCCCTTTACCTTCGCCATCAAATAGTCACGATCACTTTATTGAAGTGCCTTTGAGCGTCGCCTCTAAAGTA
TTGCTGTTAAATGCTTTTTTACAGTCAGAAATCACTCAGCAAGAGTTAGCCAGGCGAATTGGCAAACCTAAACAGGAAAT
TACTCGCTTATTTAACTTGCACCATGCGACAAAAATCGACGCCGTCCAGCTTGCGGCTAAGGCGCTTGGCAAAGAGTTAT
CGCTGGTGATGGTTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A510WIJ9

Antitoxin

Source ID Structure
AlphaFold DB A0A0E2BRK6

References