Detailed information of TA system TA155377

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): higBA (relBE)/COG4683-HTH_37
• Location: 1895055..1895706
• Replicon: chromosome
• Accession: NZ_CP051862
• Organism: Acinetobacter baumannii strain Ab-C102

Toxin (Protein)

• Gene name: higB
• Uniprot ID: S3SZA7
• Locus tag: HIN89_RS09000
• Protein ID: WP_000269903.1
• Coordinates: 1895350..1895706 (-)
• Length: 119 a.a.

Antitoxin (Protein)

• Gene name: higA
• Uniprot ID: -
• Locus tag: HIN89_RS08995
• Protein ID: WP_001140619.1
• Coordinates: 1895055..1895357 (-)
• Length: 101 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HIN89_RS08965	1890140..1890491	-	352	Protein_1744	transposase	-
HIN89_RS08970	1890634..1890882	+	249	WP_002084120.1	diguanylate cyclase	-
HIN89_RS08975	1890894..1891382	+	489	WP_038342305.1	phosphate-starvation-inducible PsiE family protein	-
HIN89_RS08980	1891369..1892179	+	811	Protein_1747	M48 family metalloprotease	-
HIN89_RS08985	1892199..1893350	+	1152	WP_000221973.1	trypsin-like peptidase domain-containing protein	-
HIN89_RS08990	1893932..1894864	-	933	WP_004739252.1	IS5-like element ISAba13 family transposase	-
HIN89_RS08995	1895055..1895357	-	303	WP_001140619.1	XRE family transcriptional regulator	Antitoxin
HIN89_RS09000	1895350..1895706	-	357	WP_000269903.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
HIN89_RS09005	1896256..1897581	-	1326	Protein_1752	ISNCY family transposase	-
HIN89_RS09010	1897926..1899005	+	1080	Protein_1753	ATP-binding cassette domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	1885532..1897257	11725
	-	inside	IScluster/Tn	-	-	1893932..1897257	3325

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-like (12-106)

Antitoxin

• HigA2-like, helix-turn-helix domain (13-89)

Sequences

Toxin

Protein

• Length: 119 a.a.
• Molecular weight: 13486.45 Da
• Isoelectric Point: 7.1645

>T155377 WP_000269903.1 NZ_CP051862:c1895706-1895350 [Acinetobacter baumannii]
MWTVITTDLFNEWLAQQDQSTQEKVLAALVVLQQQGPSLGRPLVDTVYDSKFTNMKELRVQHRGKPLRAFFAFDPLRQAI
VLCIGDKGGKKRFYKEMLDIADQQYEIHLSTLGDQSNG

Nucleotide

• Length: 357 bp

>T155377 NZ_CP068800:161180-161365 [Escherichia coli]
GTGAAAAGTGCAGACGTGATCGCCATCCTGAAGCAGCATGGCTGGGAACATATTCGAACCCGTGGCAGTCATCATCAGTT
CCGCCACCCTGTTCATCCGGGTCTGGTGACGGTTCCGCACCCTAAAAAAGATATTAAGCCCGGTACGCTGGCGCAAATTG
GGCGTCAGGCTGGTTTAACATTTTAA

Antitoxin

Protein

• Length: 101 a.a.
• Molecular weight: 11206.01 Da
• Isoelectric Point: 6.7282

>AT155377 WP_001140619.1 NZ_CP051862:c1895357-1895055 [Acinetobacter baumannii]
MAKTLQELLANRSPESQARIQQMADELLLETQLHLIREELEISQKELAATLGIKQPSLSAIENRGHDLKISTMKKYVEAM
GGKLRIDVELPTGKHIGFNV

Nucleotide

• Length: 303 bp

>AT155377 NZ_CP068800:161382-161792 [Escherichia coli]
ATGTTTTATCCCGCCTATATCCACAGTGATCCTGACGGCAGCGCCAGCGGTTTTTTCCCTGATGTTCCAGGCTGTTATTT
TGCTGGTGATACGCTGGACAACGCTTTCCAGGATGCGCGAAGTGCACTGGTCGCGCACTTCGAAACCTTATGCGAGATGA
ATGAAGAGTTGCCGCTTCCAGGCTCTGTGGAAACACATCTGGTCCAGCGTGCGCAGGACTTTATTGGTGGGCAATGGTTG
CTGGTGGATATCAATATGAATCAGTTCGAAGGTCGGGCTGAACGTATCAATATTACGATGCCGAAAAGGTTACTGAACAA
GATTGATACCTACGTGCGCAATAACCCAGACTACGCCAACAGAAGTGCGTTTCTGGCAGAAGCTGCCCGGCGTGTATTGC
CGGGCGTTTAA

Structures

Toxin

• AlphaFold DB: A0A836MG83