Detailed information of TA system TA155368

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): bsrG-as-bsrH/-
• Location: 2297062..2297352
• Replicon: chromosome
• Accession: NZ_CP051860
• Organism: Bacillus subtilis subsp. subtilis str. 168

Toxin (Protein)

• Gene name: bsrG
• Uniprot ID: L8EAY0
• Locus tag: HIR76_RS11770
• Protein ID: WP_009967548.1
• Coordinates: 2297062..2297178 (+)
• Length: 39 a.a.

Antitoxin (RNA)

Gene name	as-bsrH
Locus tag	-
Coordinates	2297173..2297352 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HIR76_RS11735	2292989..2293159	-	171	WP_009967544.1	bacteriocin sublancin-168	-
HIR76_RS11740	2293456..2293773	-	318	WP_009967545.1	sublancin immunity protein SunI	-
HIR76_RS11745	2293875..2295125	-	1251	WP_004398504.1	UV-damage repair protein uvrX	-
HIR76_RS11750	2295118..2295450	-	333	WP_004398710.1	YolD-like family protein	-
HIR76_RS11755	2295624..2295959	+	336	WP_004399073.1	hypothetical protein	-
HIR76_RS11760	2296002..2296358	-	357	WP_004398595.1	hypothetical protein	-
HIR76_RS11765	2296364..2296831	-	468	WP_003246138.1	YolA family protein	-
HIR76_RS11770	2297062..2297178	+	117	WP_009967548.1	type I toxin-antitoxin system toxin BsrG	Toxin
-	2297173..2297352	-	180	NuclAT_1	-	Antitoxin
-	2297173..2297352	-	180	NuclAT_1	-	Antitoxin
-	2297173..2297352	-	180	NuclAT_1	-	Antitoxin
-	2297173..2297352	-	180	NuclAT_1	-	Antitoxin
HIR76_RS11775	2297457..2297990	-	534	WP_004399156.1	GNAT family N-acetyltransferase	-
HIR76_RS11780	2298026..2298604	-	579	WP_004399123.1	SMI1/KNR4 family protein	-
HIR76_RS11785	2298668..2299165	-	498	WP_003246188.1	SMI1/KNR4 family protein	-
HIR76_RS11790	2299174..2300889	-	1716	WP_004398855.1	ribonuclease YeeF family protein	-
HIR76_RS11795	2300989..2301546	-	558	WP_003246042.1	SMI1/KNR4 family protein	-
HIR76_RS11800	2301630..2301815	+	186	WP_003245951.1	transposase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	2172834..2309876	137042

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Small toxic protein BsrE-like (1-38)

Sequences

Toxin

Protein

• Length: 39 a.a.
• Molecular weight: 4336.39 Da
• Isoelectric Point: 10.1022

>T155368 WP_009967548.1 NZ_CP051860:2297062-2297178 [Bacillus subtilis subsp. subtilis str. 168]
MTVYESLMIMINFGGLILNTVLLIFNIMMIVTSSQKKK

Nucleotide

• Length: 117 bp

>T155368 NZ_CP068799:3716495-3716713 [Escherichia coli]
ATGTCCGAAAAACCTTTAACGAAAACCGATTATTTAATGCGTTTACGTCGTTGTCAGACAATTGACACGCTGGAGCGTGT
TATCGAGAAAAATAAATACGAATTATCAGATAATGAACTGGCGGTATTTTACTCAGCTGCAGATCACCGCCTCGCCGAAT
TGACCATGAATAAACTGTACGACAAGATCCCTTCCTCAGTATGGAAATTTATTCGCTAA

Antitoxin

Nucleotide

• Length: 180 bp

>AT155368 NZ_CP051860:c2297352-2297173 [Bacillus subtilis subsp. subtilis str. 168]
AATGATACAATTATATAATTATTTTTTGCATTTTGTTTAATTAAATGCATAAAATAAAAAGACCAGGGTGTTGGTAGCAC
CCTGGCTCTGTACAAAAGCTGCCCATCAAAGGGCTTGCTCGTTGTCAAATCTGCGTAGGCCTAACCCTTCAGGTGTCCAA
ACTCAAGGGAAGGTCTATTT

Structures

Toxin

• AlphaFold DB: A0A7Z7EVU9

Antitoxin