Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mqsRA (relBE)/MqsR-MqsA
Location 795175..795868 Replicon chromosome
Accession NZ_CP051849
Organism Escherichia coli strain SCU-101

Toxin (Protein)


Gene name mqsR Uniprot ID S1EZG2
Locus tag HHJ20_RS03865 Protein ID WP_000415584.1
Coordinates 795175..795471 (+) Length 99 a.a.

Antitoxin (Protein)


Gene name mqsA Uniprot ID S1EBV2
Locus tag HHJ20_RS03870 Protein ID WP_000650107.1
Coordinates 795473..795868 (+) Length 132 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HHJ20_RS03830 (790263) 790263..790577 - 315 WP_000958598.1 putative quinol monooxygenase -
HHJ20_RS03835 (790608) 790608..791189 - 582 WP_000065430.1 NADPH:quinone oxidoreductase MdaB -
HHJ20_RS03840 (791508) 791508..791840 + 333 WP_000917684.1 DUF2645 family protein -
HHJ20_RS03845 (791886) 791886..793235 - 1350 WP_000673402.1 quorum sensing histidine kinase QseC -
HHJ20_RS03850 (793232) 793232..793891 - 660 WP_001221493.1 quorum sensing response regulator transcription factor QseB -
HHJ20_RS03855 (794043) 794043..794435 + 393 WP_000712658.1 OB fold stress tolerance protein YgiW -
HHJ20_RS03860 (794488) 794488..794970 + 483 WP_000183505.1 GyrI-like domain-containing protein -
HHJ20_RS03865 (795175) 795175..795471 + 297 WP_000415584.1 type II toxin-antitoxin system toxin MqsR Toxin
HHJ20_RS03870 (795473) 795473..795868 + 396 WP_000650107.1 type II toxin-antitoxin system antitoxin MqsA Antitoxin
HHJ20_RS03875 (796001) 796001..797608 + 1608 WP_021561146.1 ABC transporter substrate-binding protein -
HHJ20_RS03880 (797746) 797746..800004 + 2259 WP_021519502.1 DNA topoisomerase IV subunit A -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 795175..805356 10181


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase toxin MqsR

(5-97)

Antitoxin

Zinc finger, MqsA-type

(3-47)


Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 11231.96 Da        Isoelectric Point: 8.9070

>T155330 WP_000415584.1 NZ_CP051849:795175-795471 [Escherichia coli]
MEKRTPHTRLSQVKKLVNAGQVRTTRSALLNADELGLDFDGMCNVIIGLSESDFYKSMTTYSDHTIWQDVYRPRLVTGQV
YLKITVIHDVLIVSFKEK

Download         Length: 297 bp

>T155330 NZ_CP068796:c4589527-4589177 [Escherichia coli]
ATGGTAAAGAAAAGTGAATTTGAACGGGGAGACATTGTGCTGGTTGGCTTTGATCCAGCAAGCGGCCATGAACAGCAAGG
TGCTGGTCGACCTGCGCTTGTGCTCTCCGTTCAAGCCTTTAATCAACTGGGAATGACGCTGGTGGCCCCCATTACGCAGG
GCGGAAATTTTGCCCGTTATGCCGGATTTAGCGTTCCTTTACATTGCGAAGAAGGCGATGTGCACGGCGTGGTGCTGGTG
AATCAGGTGTGGATGATGGATCTACGCGCCCGGCTGGCAAAGCGTATTGGTCTGGCTGCGGGTGAGGTGGTGGAAGAGGC
GTTATTACGTTTGCAGGCGGTGGTGGAATAA

Antitoxin


Download         Length: 132 a.a.        Molecular weight: 14703.10 Da        Isoelectric Point: 9.2136

>AT155330 WP_000650107.1 NZ_CP051849:795473-795868 [Escherichia coli]
MKCPVCHQGEMVSGIKDIPYTFRGRKTVLKGIHGLYCVHCEESIMNKEESDAFMAQVKAFRASVNAETVAPEFIVKVRKK
LSLTQKEASEIFGGGVNAFSRYEKGNAQPHPSTIKLLRVLDKHPELLNEIR

Download         Length: 396 bp

>AT155330 NZ_CP068796:c4589772-4589521 [Escherichia coli]
ATGCGTATTACCATAAAAAGATGGGGGAACAGTTCAGGTATGGTCATTCCTAATGTTGTGATGAAAGAACTTAACTTACG
GCCGGGGCAGAGCGTGGAGGCGCAAGTGAGCAACAATCAACTGATTCTGACACCCATCTCCAGGCGCTACTCGCTTGATG
AACTGCTGGCACAGTGTGACATGAACGCCACGGAACTTAGCGAGCAGGATGTCTGGGGTAAATCCACCCCTGCGGGTGAC
GAAATATGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 3HI2

Antitoxin

Source ID Structure
PDB 3HI2
PDB 3GA8
PDB 3O9X
PDB 2KZ8
PDB 3FMY
PDB 3GN5
AlphaFold DB A0A7U9LU65

References