Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) DinJ-YafQ (relBE)/YafQ-RelB
Location 3888969..3889510 Replicon chromosome
Accession NZ_CP051751
Organism Escherichia coli strain SCU-301

Toxin (Protein)


Gene name yafQ Uniprot ID D8A3N8
Locus tag HHJ43_RS18625 Protein ID WP_000615978.1
Coordinates 3889232..3889510 (+) Length 93 a.a.

Antitoxin (Protein)


Gene name dinJ Uniprot ID Q32JN2
Locus tag HHJ43_RS18620 Protein ID WP_000729709.1
Coordinates 3888969..3889229 (+) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HHJ43_RS18600 3884317..3885372 - 1056 WP_001226153.1 DNA polymerase IV -
HHJ43_RS18605 3885443..3886228 - 786 WP_072275300.1 putative lateral flagellar export/assembly protein LafU -
HHJ43_RS18610 3886200..3887912 + 1713 Protein_3647 flagellar biosynthesis protein FlhA -
HHJ43_RS18615 3888010..3888783 - 774 WP_122999991.1 C40 family peptidase -
HHJ43_RS18620 3888969..3889229 + 261 WP_000729709.1 type II toxin-antitoxin system antitoxin DinJ Antitoxin
HHJ43_RS18625 3889232..3889510 + 279 WP_000615978.1 type II toxin-antitoxin system mRNA interferase toxin YafQ Toxin
HHJ43_RS18630 3889666..3890406 + 741 WP_001225679.1 murein L,D-transpeptidase -
HHJ43_RS18635 3890377..3891144 - 768 WP_000333380.1 class II glutamine amidotransferase -
HHJ43_RS18640 3891260..3891838 - 579 WP_000284050.1 D-sedoheptulose 7-phosphate isomerase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, YafQ-like toxin

(5-92)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(4-84)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10846.66 Da        Isoelectric Point: 10.0702

>T155271 WP_000615978.1 NZ_CP051751:3889232-3889510 [Escherichia coli]
MIQRDIEYSGQFSKDVKLAQKRHKDMNKLKYLMTLLINNTLLLPAVYKDHPLQGSWKGYRDAHVEPDWILIYKLTDKLLR
FERTGTHAALFG

Download         Length: 279 bp

>T155271 NZ_CP068771:324320-325618 [Serratia plymuthica]
ATGGAAAAGCTACGTGTGGCGCTGAATGGCACTCTTGTTGGGACGCTGGAAAAGCATGCGGGCGGCGCAATGTCTTTTGT
TTACCACGAAGAGTGGCTGGCACAAGCCGGTGCGCGCGCCATATCGTTATCCCTGCCGCTACAACCAGAACCGTTCCGCG
GTGACGTGGTGTATAACTTTTTCGACAACCTGCTGCCGGACAGCGAGCTCATTCGCAGCCGCCTACAGGCACGTTTTAGA
ACGGTAACCAAACAACCTTTTGATCTGCTCTCCAGCATTGGCAGCGACTGCGTGGGGGCGATACAGCTTTACCCTGAACA
TGCAGATATGGCCCCGGTAAAGCAAGTGAACGCCGTGCCTGTCAGTGACGAAGAAATAGAGCAGCTTCTATTGGGGTACC
GCGAGGCGCCATTGGGCATGGAGGCGGGTACTGATGATTTCCGGATCTCTCTGGCCGGTGCGCAGGAAAAGACCGCGCTG
CTTTGGTTCAGCGATCAGTGGTGTCGGCCACAAGGGAGTACGCCAACCAGCCACATCATAAAACTGCCCATTGGGCATAT
TACGCATAACAATCTGGATCTCAGCGAAAGCTGTGAGAACGAGTGGTTATGTTTACGCATTGCAGAACAGTTTGGCCTGC
CGGTAGCGCAGGCTGAGTTGGCGAGTTTTGGTGAACAAAAGGCTTTAGTTGTTGAGCGCTTCGACCGTCGTTGGGCGCGG
GATAACAGCTGGCTGATTCGTTTGCCGCAGGAGGATTTCTGCCAGGCGTTAGGCATTGCCCCAGCGCTGAAATATGAGGC
TGATGGCGGGCCCGGTATTGCGGCTGCGATGCAACTGCTAATGGGTTCTCAGCAGCCATTACTCGATCGAGACACCTTCT
TTAAAAGCCAAATTGTATTCTGGATGCTGGCGGCCATTGATGGGCATGCTAAAAACTTCAGTCTGTTCATTGAACCAGAG
ACGACCTATCGAATGACCCCGCTTTATGATGTGCTCTCTGGTTACCCTTTTATGCATGCTCGTGGCATCGCGCCACAGAA
AGCAAAAATGGCCATGGCCGTATTGGGGCAGAGTCGCCATTACCGCTGGAGCCAGATCTTGCCTCGGCATTTTATCTCTA
CCGCGAGAGCGGTGGGGTATTCTGAAGAGAAAACGCTACAGGTGATGGCTGAGCTGAAAGCGCAAACGGAGTCGGCGATC
GCTAATGTGGAAGCGATGTTGCCGGACGGCTTTCCTCGTTTTGTGAGTGATGCGATTTTTGCCGGGGTTCGGCGGCAGGC
TGAGAGGTTGCCGGGGTAG

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9333.73 Da        Isoelectric Point: 5.8129

>AT155271 WP_000729709.1 NZ_CP051751:3888969-3889229 [Escherichia coli]
MAANAFVRARIDEDLKNQAADVLAGMGLTISDLVRITLTKVAREKALPFDLREPNQLTIQSIKNSEAGVGVHKAKDADDL
FDKLGI

Download         Length: 261 bp

>AT155271 NZ_CP068771:324069-324317 [Serratia plymuthica]
ATGAAAATCACCTCGGCAAAGATGTTGGCGCATGCGTTACGCAATGAACGTAAAAAGCGTAACCAAAGCCAAAGTAAAAC
TGCTGACAGTATTGGGTTAAAGCAGGCCACGGTTTCCGCGTTTGAAAACAACCCGGACGGCACGCGGCTGGATACGTTGT
TCAAACTGCTTGCTGCGCTGGATTTAGAGCTACAAGTGACTCCGCGTGGTAAGCCGGCCGATCCCAAAACCTGGGATCAG
GAGTGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829G928

Antitoxin

Source ID Structure
AlphaFold DB A0A829FY17

References