155253

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) prlF-yhaV (relBE)/YhaV-PrlF
Location 635225..636024 Replicon chromosome
Accession NZ_CP051751
Organism Escherichia coli strain SCU-301

Toxin (Protein)


Gene name yhaV Uniprot ID V0SSH7
Locus tag HHJ43_RS03005 Protein ID WP_000347273.1
Coordinates 635225..635689 (-) Length 155 a.a.

Antitoxin (Protein)


Gene name prlF Uniprot ID D6JF08
Locus tag HHJ43_RS03010 Protein ID WP_001308975.1
Coordinates 635689..636024 (-) Length 112 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HHJ43_RS02975 630226..630660 - 435 WP_000948834.1 PTS sugar transporter subunit IIA -
HHJ43_RS02980 630678..631556 - 879 WP_001295548.1 PTS system mannose/fructose/sorbose family transporter subunit IID -
HHJ43_RS02985 631546..632325 - 780 WP_000406214.1 PTS mannose/fructose/sorbose/N-acetylgalactosamine transporter subunit IIC -
HHJ43_RS02990 632336..632809 - 474 WP_001295547.1 PTS N-acetylgalactosamine transporter subunit IIB -
HHJ43_RS02995 632832..634112 - 1281 WP_023908831.1 tagatose-bisphosphate aldolase subunit KbaZ -
HHJ43_RS03000 634361..635170 + 810 WP_000072187.1 aga operon transcriptional regulator AgaR -
HHJ43_RS03005 635225..635689 - 465 WP_000347273.1 type II toxin-antitoxin system ribonuclease toxin YhaV Toxin
HHJ43_RS03010 635689..636024 - 336 WP_001308975.1 type II toxin-antitoxin system antitoxin PrlF Antitoxin
HHJ43_RS03015 636173..637744 - 1572 WP_096986739.1 galactarate dehydratase -
HHJ43_RS03020 638119..639453 + 1335 WP_000599651.1 galactarate/glucarate/glycerate transporter GarP -
HHJ43_RS03025 639469..640239 + 771 WP_001058227.1 2-dehydro-3-deoxyglucarate aldolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin endonuclease, YhaV

(12-150)

Antitoxin

PrlF antitoxin

(14-110)


Sequences

Toxin        


Download         Length: 155 a.a.        Molecular weight: 17836.25 Da        Isoelectric Point: 9.6924

>T155253 WP_000347273.1 NZ_CP051751:c635689-635225 [Escherichia coli]
MDFPQRVNGWALYAHPCFQETYDALVAEVETLKGKDPENYQRKAATKLLAVVHKVIEEHITVNPSSPAFRHGKSLGSGKN
KDWSRVKFGAGRYRLFFRYSEKEKVIILGWMNDENTLRTYGKKTDAYTVFSKMLKRGHPPADWETLTRETEETH

Download         Length: 465 bp

>T155253 NZ_CP068714:c10131-9817 [Staphylococcus pseudoxylosus]
GTGGCTAAATTGAATGTTACCTTTTCACCACAAGCATTTGATGATTATGAATATTTTCAGATAAAAGATAGAAAGAAGGT
TAAAAGGATGAATCAGTTATTAAAAAGTATCTCTAGAGATGGGACATTAGATGCTATAGGTAAACCTGAAAAGTTAGTTG
GCAATTTTTTTGGATATTACAGTAGACGAATTAACCAAGAACATAGATTGGTATATACAGTAAATGACATAATTTTACTT
ATCGGAAGTGCATATGCTTATATATTTACAGATGGTATAATAATGGAGTCGCCTATCTCTCAGGCGTCAATTTGA

Antitoxin


Download         Length: 112 a.a.        Molecular weight: 12343.97 Da        Isoelectric Point: 4.8616

>AT155253 WP_001308975.1 NZ_CP051751:c636024-635689 [Escherichia coli]
MPANARSHAVLTTESKVTIRGQTTIPAPVREALKLKPGLDSIHYEILPGGQVFMCRLGDEQEDHTMNAFLRFLDADIQNN
PQKTRPFNIQQGKKLVAGMDVNIDDEIGDDE

Download         Length: 336 bp

>AT155253 NZ_CP068714:c10380-10132 [Staphylococcus pseudoxylosus]
ATGATTGTTAAATCTTATTCATATGTACGTAAAAACTTTAAAGATATGATTAATAAAGTGAATAATGATAGCGATACGAT
AACAATTACAACAAAAGATCGTAATGCAGTTATAATGTCGGAAGATAATTATAATGAAATAATGGAAACACTATACTTGC
AACAAAATCCTGCCAATTCGAAACATCTATCAGAATCTATTGAAAACCTAAAACGTGGTAATGTAAAAGCTAAGGATATT
TTGATATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB V0SSH7

Antitoxin

Source ID Structure
AlphaFold DB D6JF08

References