Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-YefM
Location 1901905..1902407 Replicon chromosome
Accession NZ_CP051744
Organism Escherichia coli strain SCU-484

Toxin (Protein)


Gene name yoeB Uniprot ID -
Locus tag HHJ53_RS08865 Protein ID WP_128549352.1
Coordinates 1902153..1902407 (+) Length 85 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID S1Q063
Locus tag HHJ53_RS08860 Protein ID WP_001259255.1
Coordinates 1901905..1902156 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HHJ53_RS08835 1897083..1898150 - 1068 WP_000080093.1 bifunctional histidinol-phosphatase/imidazoleglycerol-phosphate dehydratase HisB -
HHJ53_RS08840 1898150..1899220 - 1071 WP_000108935.1 histidinol-phosphate transaminase -
HHJ53_RS08845 1899217..1900521 - 1305 WP_001350335.1 histidinol dehydrogenase -
HHJ53_RS08850 1900527..1901426 - 900 WP_000131782.1 ATP phosphoribosyltransferase -
HHJ53_RS08855 1901572..1901622 - 51 WP_001364200.1 his operon leader peptide -
HHJ53_RS08860 1901905..1902156 + 252 WP_001259255.1 YoeB-YefM toxin-antitoxin system antitoxin YefM Antitoxin
HHJ53_RS08865 1902153..1902407 + 255 WP_128549352.1 type II toxin-antitoxin system mRNA interferase toxin YoeB Toxin
HHJ53_RS08870 1902490..1903314 + 825 WP_000754741.1 SDR family oxidoreductase -
HHJ53_RS08875 1903360..1904289 + 930 WP_000803366.1 LysR family transcriptional regulator -
HHJ53_RS08880 1904504..1904566 + 63 WP_010723108.1 membrane protein YoeI -
HHJ53_RS08885 1904556..1905914 + 1359 WP_000019194.1 putrescine/proton symporter PlaP -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(5-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-73)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 10167.58 Da        Isoelectric Point: 8.0427

>T155225 WP_128549352.1 NZ_CP051744:1902153-1902407 [Escherichia coli]
VKLIWSEESWDDYLYWQETDKRIVKKINELIKDTRRTPFEGKGKPEPLKHNLSGFWSRRITEEHRLVYAVTDDSLLIAAC
RYHF

Download         Length: 255 bp

>T155225 NZ_CP068706:2514368-2514475 [Escherichia coli]
ATGACGCTCGCGCAGTTTGCCATGATTTTCTGGCACGACCTGGCAGCACCGATCCTGGCGGGAATTATTACCGCAGCGAT
TGTCAGCTGGTGGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9307.58 Da        Isoelectric Point: 4.7954

>AT155225 WP_001259255.1 NZ_CP051744:1901905-1902156 [Escherichia coli]
MRTISYSEARQNLSATMMKAVEDHAPILITRQNGEACVLMSLEEYNSLEETAYLLRSPANARRLMDSIDSLKSGKGTEKD
IIE

Download         Length: 252 bp

>AT155225 NZ_CP068706:c2514321-2514255 [Escherichia coli]
TGTCTGGTTTCAAGATTAGCCCCCGTTTTGTTGTCAGGTTTTACCTCTCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
PDB 2A6Q
AlphaFold DB A0A7U9LNR0

References