Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) hok-sok/-
Location 3707542..3707800 Replicon chromosome
Accession NZ_CP051735
Organism Escherichia coli strain SCU-108

Toxin (Protein)


Gene name hokC Uniprot ID S1NX00
Locus tag HHJ26_RS17740 Protein ID WP_000809168.1
Coordinates 3707542..3707694 (-) Length 51 a.a.

Antitoxin (RNA)


Gene name sokC
Locus tag -
Coordinates 3707743..3707800 (+)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HHJ26_RS17720 3702787..3703500 - 714 WP_001102393.1 acidic protein MsyB -
HHJ26_RS17725 3703526..3703930 - 405 WP_000843687.1 DUF2541 family protein -
HHJ26_RS17730 3704302..3706218 + 1917 WP_000516135.1 molecular chaperone DnaK -
HHJ26_RS17735 3706307..3707437 + 1131 WP_001118464.1 molecular chaperone DnaJ -
HHJ26_RS17740 3707542..3707694 - 153 WP_000809168.1 type I toxin-antitoxin system toxin MokC Toxin
- 3707743..3707800 + 58 - - Antitoxin
HHJ26_RS17745 3708306..3709067 + 762 WP_001274823.1 hypothetical protein -
HHJ26_RS17750 3709087..3710580 + 1494 WP_001350775.1 sulfatase-like hydrolase/transferase -
HHJ26_RS17755 3710709..3711968 + 1260 WP_000494924.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Hok/gef cell toxic protein

(6-47)


Sequences

Toxin        


Download         Length: 51 a.a.        Molecular weight: 5501.57 Da        Isoelectric Point: 7.1312

>T155171 WP_000809168.1 NZ_CP051735:c3707694-3707542 [Escherichia coli]
MKQHKAMIVALIVICITAVVAALVTRKDLCEVHIRTGQTEVAVFTAYESE

Download         Length: 153 bp

>T155171 NZ_CP068687:c131658-131500 [Klebsiella pneumoniae subsp. pneumoniae]
ATGAAACTACCACGAAGTTCCCTTGTCTGGTGTGTGTTGATCGTGTGTCTCACACTGTTGATATTCACTTATCTGACACG
AAAATCGCTGTGCGAGATTCGTTACAGAGACGGACACAGGGAGGTGGCGGCTTTCATGGCTTACGAATCCGGTAAGTAG

Antitoxin


Download         Length: 58 bp

>AT155171 NZ_CP051735:3707743-3707800 [Escherichia coli]
GTTCTGCATATAGGGGGCCTCGGGTTGATGGTAAAATATCACTCGGGGCTTTTCTCTA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S1NX00

Antitoxin

Download structure file

References