Detailed information of TA system TA155161

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): yefM-yoeB (relBE)/YoeB-YefM
• Location: 827488..827990
• Replicon: chromosome
• Accession: NZ_CP051735
• Organism: Escherichia coli strain SCU-108

Toxin (Protein)

• Gene name: yoeB
• Uniprot ID: A0A0H2Z0A6
• Locus tag: HHJ26_RS03930
• Protein ID: WP_000767826.1
• Coordinates: 827488..827742 (-)
• Length: 85 a.a.

Antitoxin (Protein)

• Gene name: yefM
• Uniprot ID: -
• Locus tag: HHJ26_RS03935
• Protein ID: WP_071686836.1
• Coordinates: 827739..827990 (-)
• Length: 84 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HHJ26_RS03910	823981..825339	-	1359	WP_000019194.1	putrescine/proton symporter PlaP	-
HHJ26_RS03915	825329..825391	-	63	WP_010723108.1	membrane protein YoeI	-
HHJ26_RS03920	825606..826535	-	930	WP_000803363.1	LysR family transcriptional regulator	-
HHJ26_RS03925	826581..827405	-	825	WP_000754737.1	SDR family oxidoreductase	-
HHJ26_RS03930	827488..827742	-	255	WP_000767826.1	type II toxin-antitoxin system mRNA interferase toxin YoeB	Toxin
HHJ26_RS03935	827739..827990	-	252	WP_071686836.1	YoeB-YefM toxin-antitoxin system antitoxin YefM	Antitoxin
HHJ26_RS03940	828273..828323	+	51	WP_001364200.1	his operon leader peptide	-
HHJ26_RS03945	828469..829368	+	900	WP_000131782.1	ATP phosphoribosyltransferase	-
HHJ26_RS03950	829374..830678	+	1305	WP_001350692.1	histidinol dehydrogenase	-
HHJ26_RS03955	830675..831745	+	1071	WP_000108997.1	histidinol-phosphate transaminase	-
HHJ26_RS03960	831745..832812	+	1068	WP_000080128.1	bifunctional histidinol-phosphatase/imidazoleglycerol-phosphate dehydratase HisB	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin YoeB (5-84)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-73)

Sequences

Toxin

Protein

• Length: 85 a.a.
• Molecular weight: 10195.64 Da
• Isoelectric Point: 8.0353

>T155161 WP_000767826.1 NZ_CP051735:c827742-827488 [Escherichia coli]
VKLIWSEESWDDYLYWQETDKRIVKKINELIKDTRRTPFEGKGKPEPLKHNLSGFWSRRIIEEHRLVYAVTDDSLLIAAC
RYHY

Nucleotide

• Length: 255 bp

>T155161 NZ_CP068684:c5040409-5040041 [Klebsiella pneumoniae subsp. pneumoniae]
ATGACGCTGCAGATTATCTCAGCGGAAGAGATAATACAGTTTCACGACAGGCTGCTCCGCGTCACGCCTGGCGTTGCCGG
TATGCCCGATCCAGGGCGTGCCGAAGCGATAATGTATAGGGTGCTAAACAAAATTGAATATGAAGGTGTGACAGACGTGT
GGCGACTCGCTGCGATGCATCTGCTGGCGATTTCTCGCGGTCATATATTTAATGATGGTAATAAGCGTACGGCACTGTTT
ATCACTCTGCTTTTTTTAAAGCGAAATGGAATTATATTGCCGGCGAATCCAGACTTCGTCGGCATGACCGTCGAGGCGGC
AGCAGGGCAACTTACCCTGGAACAGATTGTCGCGCGCTTGCGCGGATGA

Antitoxin

Protein

• Length: 84 a.a.
• Molecular weight: 9333.62 Da
• Isoelectric Point: 4.7954

>AT155161 WP_071686836.1 NZ_CP051735:c827990-827739 [Escherichia coli]
MRTISYSEARQNLSATMMKAVEDHAPILITRQNGEPCVLMSLEEYNSLEETAYLLRSPANARRLMDSIDSLKSGKGTEKD
IIE

Nucleotide

• Length: 252 bp

>AT155161 NZ_CP068684:c5040627-5040406 [Klebsiella pneumoniae subsp. pneumoniae]
ATGAGAACGGTTAACTATAGCGAAGCCCGGCAAAATCTGGCCGATGTGCTGGAAAGCGCAGTGACAGGTGTACCTGTGAC
CATTACCCGTCGTGGGCATAAATCTGCAGTCATCATTAGTGCAGAAGAGTTTGAACGCTACCAGACGGCCAGAATGGATG
ATGAGTTCGCGGCTATCATGGCGGTTCATGGTGATGAGATCAGGGAGCTTGCGGATAAATGA

Structures

Toxin

• AlphaFold DB: A0A0H2Z0A6