Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | yafN-yafO (relBE)/YafO-YafN |
Location | 928834..929528 | Replicon | chromosome |
Accession | NZ_CP051733 | ||
Organism | Escherichia coli strain SCU-109 |
Toxin (Protein)
Gene name | yafO | Uniprot ID | Q0T7Q5 |
Locus tag | HHJ27_RS04390 | Protein ID | WP_001263491.1 |
Coordinates | 929130..929528 (+) | Length | 133 a.a. |
Antitoxin (Protein)
Gene name | yafN | Uniprot ID | L4JHF0 |
Locus tag | HHJ27_RS04385 | Protein ID | WP_000554755.1 |
Coordinates | 928834..929127 (+) | Length | 98 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
HHJ27_RS04360 | 924455..924811 | - | 357 | WP_001030484.1 | type II toxin-antitoxin system HicB family antitoxin | - |
HHJ27_RS04365 | 924804..925082 | - | 279 | WP_000598760.1 | type II toxin-antitoxin system HicA family toxin | - |
HHJ27_RS04370 | 925187..926899 | - | 1713 | Protein_840 | flagellar biosynthesis protein FlhA | - |
HHJ27_RS04375 | 926871..927656 | + | 786 | WP_074157994.1 | putative lateral flagellar export/assembly protein LafU | - |
HHJ27_RS04380 | 927727..928782 | + | 1056 | WP_001550655.1 | DNA polymerase IV | - |
HHJ27_RS04385 | 928834..929127 | + | 294 | WP_000554755.1 | type I toxin-antitoxin system antitoxin YafN | Antitoxin |
HHJ27_RS04390 | 929130..929528 | + | 399 | WP_001263491.1 | type II toxin-antitoxin system mRNA interferase toxin YafO | Toxin |
HHJ27_RS04395 | 929538..929990 | + | 453 | WP_019842500.1 | GNAT family N-acetyltransferase | - |
HHJ27_RS04400 | 930236..930442 | + | 207 | Protein_846 | RtcB family protein | - |
HHJ27_RS24455 | 930438..930790 | + | 353 | Protein_847 | peptide chain release factor H | - |
HHJ27_RS04410 | 930847..932304 | - | 1458 | WP_001293009.1 | cytosol nonspecific dipeptidase | - |
HHJ27_RS04415 | 932565..933023 | + | 459 | WP_001291990.1 | xanthine phosphoribosyltransferase | - |
HHJ27_RS04420 | 933115..934359 | + | 1245 | WP_000189541.1 | esterase FrsA | - |
- | 933619..933699 | + | 81 | NuclAT_10 | - | - |
- | 933619..933699 | + | 81 | NuclAT_10 | - | - |
- | 933619..933699 | + | 81 | NuclAT_10 | - | - |
- | 933619..933699 | + | 81 | NuclAT_10 | - | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 133 a.a. Molecular weight: 15457.86 Da Isoelectric Point: 8.0949
>T155124 WP_001263491.1 NZ_CP051733:929130-929528 [Escherichia coli]
MRVFKTKLIRLQLTAEELDALTADFISYKRDGVLPDIFGRDALYDDSFTWPLIKFERVAHIHLANVNNPFPPQLRQFSRT
NDEAHLVYCQGAFDEQAWLLIAILKPEPHKLARDNNQMHKIGKMAEAFRMRF
MRVFKTKLIRLQLTAEELDALTADFISYKRDGVLPDIFGRDALYDDSFTWPLIKFERVAHIHLANVNNPFPPQLRQFSRT
NDEAHLVYCQGAFDEQAWLLIAILKPEPHKLARDNNQMHKIGKMAEAFRMRF
Download Length: 399 bp
>T155124 NZ_CP068680:c611869-611696 [Escherichia coli]
ATGGCACTATTCTCTAAAATATTAATTTTTTATGTGATTGGTGTGAACATATCCTTTGTCATTATCTGGTTTATCTCACA
TGAGAAAACACATATTCGTTTACTTAGTGCATTCCTGGTCGGAATAACCTGGCCAATGAGTCTGCCTGTGGCATTACTTT
TTTCTCTCTTTTAG
ATGGCACTATTCTCTAAAATATTAATTTTTTATGTGATTGGTGTGAACATATCCTTTGTCATTATCTGGTTTATCTCACA
TGAGAAAACACATATTCGTTTACTTAGTGCATTCCTGGTCGGAATAACCTGGCCAATGAGTCTGCCTGTGGCATTACTTT
TTTCTCTCTTTTAG
Antitoxin
Download Length: 98 a.a. Molecular weight: 11235.78 Da Isoelectric Point: 5.2170
>AT155124 WP_000554755.1 NZ_CP051733:928834-929127 [Escherichia coli]
MHRILAEKSVNITELRKNPAKYFIDQPVAVLSNNRPAGYLLSASAFEALMDMLAEQEEKKLVKARFRPSAARLEEITRRA
EQYLNDMTDDDFNDFKE
MHRILAEKSVNITELRKNPAKYFIDQPVAVLSNNRPAGYLLSASAFEALMDMLAEQEEKKLVKARFRPSAARLEEITRRA
EQYLNDMTDDDFNDFKE
Download Length: 294 bp
>AT155124 NZ_CP068680:c612193-611897 [Escherichia coli]
ATGGAAGGTAAAAACAAGTTCAATACTTATGTTGTTTCTTTTGATTATCCATCATCTTATTCCTCAGTGTTCTTAAGATT
AAGATCATTGATGTATGATATGAATTTCTCCTCTATCGTGGCTGATGAATATGGGATACCACGACAATTGAATGAAAACT
CCTTCGCAATAACGACATCGTTAGCCGCAAGTGAAATCGAAGATTTAATCAGGCTCAAATGCTTAGACTTACCGGATATT
GATTTTGACCTCAACATTATGACAGTTGATGACTATTTCCGTCAGTTTTACAAGTAG
ATGGAAGGTAAAAACAAGTTCAATACTTATGTTGTTTCTTTTGATTATCCATCATCTTATTCCTCAGTGTTCTTAAGATT
AAGATCATTGATGTATGATATGAATTTCTCCTCTATCGTGGCTGATGAATATGGGATACCACGACAATTGAATGAAAACT
CCTTCGCAATAACGACATCGTTAGCCGCAAGTGAAATCGAAGATTTAATCAGGCTCAAATGCTTAGACTTACCGGATATT
GATTTTGACCTCAACATTATGACAGTTGATGACTATTTCCGTCAGTTTTACAAGTAG
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Structures
Toxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A4P7TPK7 |
Antitoxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A829G9H5 |