Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-YefM
Location 1822670..1823172 Replicon chromosome
Accession NZ_CP051727
Organism Escherichia coli strain SCU-111

Toxin (Protein)


Gene name yoeB Uniprot ID U9YDH0
Locus tag HHJ28_RS08575 Protein ID WP_000767829.1
Coordinates 1822918..1823172 (+) Length 85 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID S1Q063
Locus tag HHJ28_RS08570 Protein ID WP_001259255.1
Coordinates 1822670..1822921 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HHJ28_RS08545 1817848..1818915 - 1068 WP_000080128.1 bifunctional histidinol-phosphatase/imidazoleglycerol-phosphate dehydratase HisB -
HHJ28_RS08550 1818915..1819985 - 1071 WP_000108994.1 histidinol-phosphate transaminase -
HHJ28_RS08555 1819982..1821286 - 1305 WP_024240936.1 histidinol dehydrogenase -
HHJ28_RS08560 1821292..1822191 - 900 WP_024240937.1 ATP phosphoribosyltransferase -
HHJ28_RS08565 1822337..1822387 - 51 WP_001364200.1 his operon leader peptide -
HHJ28_RS08570 1822670..1822921 + 252 WP_001259255.1 YoeB-YefM toxin-antitoxin system antitoxin YefM Antitoxin
HHJ28_RS08575 1822918..1823172 + 255 WP_000767829.1 type II toxin-antitoxin system mRNA interferase toxin YoeB Toxin
HHJ28_RS08580 1823255..1824079 + 825 WP_000754737.1 SDR family oxidoreductase -
HHJ28_RS08585 1824125..1825054 + 930 WP_000803351.1 LysR family transcriptional regulator -
HHJ28_RS08590 1825269..1825331 + 63 WP_010723108.1 membrane protein YoeI -
HHJ28_RS08595 1825321..1826679 + 1359 WP_000019197.1 putrescine/proton symporter PlaP -
HHJ28_RS08600 1826858..1827916 + 1059 WP_000492339.1 transport protein YeeE -
HHJ28_RS08605 1827930..1828157 + 228 WP_000234896.1 sulfurtransferase TusA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(2-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-73)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 10183.58 Da        Isoelectric Point: 8.0353

>T155083 WP_000767829.1 NZ_CP051727:1822918-1823172 [Escherichia coli]
VKLIWSEESWDDYLYWQETDKRIVKKINELIKDTRRTPFEGKGKPEPLKHNLSGFWSRRITEEHRLVYAVTDDSLLIAAC
RYHY

Download         Length: 255 bp

>T155083 NZ_CP068627:1340135-1340437 [Vibrio parahaemolyticus]
ATGGCTGAAATAATCTGGACTGAGCCAGCGTTATCTGACCTCAACGATATCGCTGATTACATCGCACTTGAAAATATAGT
AGCTGCAAAGCAGTTAGTGCAAACGATCTTCTCCAAAGTTGAACGCCTAGAAACATTTCCTGAATCAGGTCGTATTCCTC
CCGAACTAGAACATTTAAGTTATCGTGAAGTTGTCGTTAATCCATGTCGTGTTTTCTATAAGCAAGACGGTGACAAAGTG
TTTATTCTGTTTGTTATGCGTACTGAGAGAGATTTGCGTAAGTTCTTGTTGAGTAAGCAATAA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9307.58 Da        Isoelectric Point: 4.7954

>AT155083 WP_001259255.1 NZ_CP051727:1822670-1822921 [Escherichia coli]
MRTISYSEARQNLSATMMKAVEDHAPILITRQNGEACVLMSLEEYNSLEETAYLLRSPANARRLMDSIDSLKSGKGTEKD
IIE

Download         Length: 252 bp

>AT155083 NZ_CP068627:1339890-1340147 [Vibrio parahaemolyticus]
ATGAAAGTAGAACTAGTTACATCACTTAAACGTCAAGCAACTAAGATCCTCGCCGATCTCCACGACACTAAAGAACCAGT
GTTAATTACCGAGCATGGTAAGCCATCCGCGTATCTAGTTGATGTTGATGATTACGAGTTTATGCAAAATCGTTTGGCTA
TTCTGGAGGGGATTGCACGAGGTGAGCGGGCACTAGCTGACGGTAAAGTGGTAAGTCATGATGAAGCCAAGGACAAAATG
TCAAAATGGCTGAAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6NY6
PDB 2A6S
PDB 6OXA
PDB 2A6R
PDB 4V8X
PDB 6OTR
PDB 6OXI
PDB 2A6Q

Antitoxin

Source ID Structure
PDB 2A6Q
AlphaFold DB A0A7U9LNR0

References