Detailed information of TA system TA155022

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): ldrD-rdlD/Ldr(toxin)
• Location: 2627131..2627353
• Replicon: chromosome
• Accession: NZ_CP051719
• Organism: Escherichia coli strain SCU-116

Toxin (Protein)

• Gene name: ldrD
• Uniprot ID: A0A0D6GD35
• Locus tag: HHJ31_RS12660
• Protein ID: WP_000170745.1
• Coordinates: 2627131..2627238 (-)
• Length: 36 a.a.

Antitoxin (RNA)

Gene name	rdlD
Locus tag	-
Coordinates	2627295..2627353 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HHJ31_RS12630	2622184..2622372	-	189	WP_001063314.1	YhjR family protein	-
HHJ31_RS12635	2622645..2624216	+	1572	WP_001204957.1	cellulose biosynthesis protein BcsE	-
HHJ31_RS12640	2624213..2624404	+	192	WP_000988308.1	cellulose biosynthesis protein BcsF	-
HHJ31_RS12645	2624401..2626080	+	1680	WP_000191567.1	cellulose biosynthesis protein BcsG	-
HHJ31_RS12650	2626166..2626273	-	108	WP_001295224.1	type I toxin-antitoxin system toxin Ldr family protein	-
HHJ31_RS12655	2626649..2626756	-	108	WP_001295224.1	type I toxin-antitoxin system toxin Ldr family protein	-
HHJ31_RS12660	2627131..2627238	-	108	WP_000170745.1	type I toxin-antitoxin system toxin Ldr family protein	Toxin
-	2627295..2627353	+	59	-	-	Antitoxin
HHJ31_RS12665	2627714..2628985	+	1272	WP_001332306.1	amino acid permease	-
HHJ31_RS12670	2629015..2630019	-	1005	WP_000103579.1	dipeptide ABC transporter ATP-binding subunit DppF	-
HHJ31_RS12675	2630016..2630999	-	984	WP_001196477.1	dipeptide ABC transporter ATP-binding protein	-
HHJ31_RS12680	2631010..2631912	-	903	WP_000084677.1	dipeptide ABC transporter permease DppC	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Type I toxin-antitoxin system, toxin Ldr (1-35)

Sequences

Toxin

Protein

• Length: 36 a.a.
• Molecular weight: 3855.68 Da
• Isoelectric Point: 9.0157

>T155022 WP_000170745.1 NZ_CP051719:c2627238-2627131 [Escherichia coli]
MTLAELGMAFWHDLAAPVIAGILASMIVSWLNKRK

Nucleotide

• Length: 108 bp

>T155022 NZ_CP068602:325717-326085 [Klebsiella pneumoniae]
ATGACGCTGCAGATTATCTCAGCGGAAGAGATAATACAGTTTCACGACAGGCTGCTCCGCGTCACGCCTGGCGTTGCCGG
TATGCCCGATCCAGGGCGTGCCGAAGCGATAATGTATAGGGTGCTAAACAAAATTGAATATGAAGGTGTGACAGACGTGT
GGCGACTCGCTGCGATGCATCTGCTGGCGATTTCTCGCGGTCATATATTTAATGATGGTAATAAGCGTACGGCACTGTTT
ATCACTCTGCTTTTTTTAAAGCGAAATGGAATTATATTGCCGGCGAATCCAGACTTCGTCGGCATGACCGTCGAGGCGGC
AGCAGGGCAACTTACCCTGGAACAGATTGTCGCGCGCTTGCGCGGATGA

Antitoxin

Nucleotide

• Length: 59 bp

>AT155022 NZ_CP051719:2627295-2627353 [Escherichia coli]
TCAAGATTAGCCCCCGTGATGTTGTCAGGTGCATACCTGCAACGTGCGGGGGTTTTCTC

Structures

Toxin

• AlphaFold DB: A0A0D6GD35

Antitoxin