155003

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 259860..260422 Replicon chromosome
Accession NZ_CP051719
Organism Escherichia coli strain SCU-116

Toxin (Protein)


Gene name higB Uniprot ID S1Q1V8
Locus tag HHJ31_RS01400 Protein ID WP_000605675.1
Coordinates 260144..260422 (-) Length 93 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID S1PAQ1
Locus tag HHJ31_RS01395 Protein ID WP_000781370.1
Coordinates 259860..260144 (-) Length 95 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HHJ31_RS01380 255041..258088 + 3048 WP_011478186.1 formate dehydrogenase-N subunit alpha -
HHJ31_RS01385 258101..258985 + 885 WP_001240584.1 formate dehydrogenase N subunit beta -
HHJ31_RS01390 258978..259631 + 654 WP_000045647.1 formate dehydrogenase-N subunit gamma -
HHJ31_RS01395 259860..260144 - 285 WP_000781370.1 HigA family addiction module antidote protein Antitoxin
HHJ31_RS01400 260144..260422 - 279 WP_000605675.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
HHJ31_RS01405 260608..261618 - 1011 WP_000642412.1 alcohol dehydrogenase AdhP -
HHJ31_RS01410 261752..263449 - 1698 WP_000433462.1 malate dehydrogenase -
HHJ31_RS01415 263605..263742 - 138 WP_000841554.1 stationary-phase-induced ribosome-associated protein -
HHJ31_RS01420 263844..264059 - 216 WP_000495766.1 biofilm-dependent modulation protein -
HHJ31_RS01425 264404..264835 + 432 WP_000152310.1 peroxiredoxin OsmC -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(4-92)

Antitoxin

Toxin-antitoxin system, antidote protein, HigA

(1-88)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10537.16 Da        Isoelectric Point: 7.3206

>T155003 WP_000605675.1 NZ_CP051719:c260422-260144 [Escherichia coli]
MIMNFRHKGLRDLFLLGKTSGVIPTQVKRLRHRLAVIDAACCLADIDMPGYRLHPLSGDRDGIWAISVSGNWRITFEFVN
GDAYILDYEDYH

Download         Length: 279 bp

>T155003 NZ_CP068591:c2181560-2181453 [Escherichia coli]
ATGACGCTCGCGAAGTTTGCCATGATTTTCTGGCACGACCTGGCAGCACCGATCCTGGCGGGGATTATTACCGCAGCGAT
TGTCGGCTGGTGGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 95 a.a.        Molecular weight: 10401.08 Da        Isoelectric Point: 8.8567

>AT155003 WP_000781370.1 NZ_CP051719:c260144-259860 [Escherichia coli]
MKMANHPRPGDIIQESLDELNVSLREFARAMEIAPSTASRLLTGKAALTPEMAIKLSVVIGSSPQMWLNLQNAWSLAEAE
KTVDVSRLRRLVTQ

Download         Length: 285 bp

>AT155003 NZ_CP068591:2181613-2181674 [Escherichia coli]
TGGTTCAAGATTAGCCCCCGTTCTGTTGTCAGGTTTTACCTCTCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S1Q1V8

Antitoxin

Source ID Structure
AlphaFold DB A0A829CUG6

References