Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) hok-sok/-
Location 3983632..3983890 Replicon chromosome
Accession NZ_CP051714
Organism Escherichia coli strain SCU-122

Toxin (Protein)


Gene name hokC Uniprot ID S1NX00
Locus tag HHJ35_RS19005 Protein ID WP_000809168.1
Coordinates 3983738..3983890 (+) Length 51 a.a.

Antitoxin (RNA)


Gene name sokC
Locus tag -
Coordinates 3983632..3983689 (-)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HHJ35_RS18990 3979464..3980723 - 1260 WP_001557213.1 hypothetical protein -
HHJ35_RS18995 3980852..3982345 - 1494 WP_001350775.1 sulfatase-like hydrolase/transferase -
HHJ35_RS19000 3982365..3983126 - 762 WP_001274823.1 hypothetical protein -
- 3983632..3983689 - 58 - - Antitoxin
HHJ35_RS19005 3983738..3983890 + 153 WP_000809168.1 type I toxin-antitoxin system toxin MokC Toxin
HHJ35_RS19010 3983995..3985125 - 1131 WP_001118464.1 molecular chaperone DnaJ -
HHJ35_RS19015 3985214..3987130 - 1917 WP_000516135.1 molecular chaperone DnaK -
HHJ35_RS19020 3987502..3987906 + 405 WP_000843687.1 DUF2541 family protein -
HHJ35_RS19025 3987932..3988645 + 714 WP_001102393.1 acidic protein MsyB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Hok/gef cell toxic protein

(6-47)


Sequences

Toxin        


Download         Length: 51 a.a.        Molecular weight: 5501.57 Da        Isoelectric Point: 7.1312

>T154972 WP_000809168.1 NZ_CP051714:3983738-3983890 [Escherichia coli]
MKQHKAMIVALIVICITAVVAALVTRKDLCEVHIRTGQTEVAVFTAYESE

Download         Length: 153 bp

>T154972 NZ_CP068561:3650565-3650717 [Clostridioides difficile]
ATGGATAATTTTTTACAAGGTATATTAGCAAGTTTAGTTGCCAGTTTAATAGTTTACTTAACTAGTAAGTTATTTAAAAA
AGTAAAAAGCCACTCTGGCAGGAGTGACTTTAGTTTTGAACTAGAAATCAAGTTCAAAAAGAATAAACATTAG

Antitoxin


Download         Length: 58 bp

>AT154972 NZ_CP051714:c3983689-3983632 [Escherichia coli]
GTTCTGCATATAGGGGGCCTCGGGTTGATGGTAAAATATCACTCGGGGCTTTTCTCTA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S1NX00

Antitoxin

Download structure file

References