154967

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 2525746..2526308 Replicon chromosome
Accession NZ_CP051714
Organism Escherichia coli strain SCU-122

Toxin (Protein)


Gene name higB Uniprot ID S1Q1V8
Locus tag HHJ35_RS11975 Protein ID WP_000605675.1
Coordinates 2525746..2526024 (+) Length 93 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID S1PAQ1
Locus tag HHJ35_RS11980 Protein ID WP_000781370.1
Coordinates 2526024..2526308 (+) Length 95 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HHJ35_RS11950 2521333..2521764 - 432 WP_000152310.1 peroxiredoxin OsmC -
HHJ35_RS11955 2522109..2522324 + 216 WP_000495766.1 biofilm-dependent modulation protein -
HHJ35_RS11960 2522426..2522563 + 138 WP_000841554.1 stationary-phase-induced ribosome-associated protein -
HHJ35_RS11965 2522719..2524416 + 1698 WP_000433462.1 malate dehydrogenase -
HHJ35_RS11970 2524550..2525560 + 1011 WP_000642412.1 alcohol dehydrogenase AdhP -
HHJ35_RS11975 2525746..2526024 + 279 WP_000605675.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
HHJ35_RS11980 2526024..2526308 + 285 WP_000781370.1 HigA family addiction module antidote protein Antitoxin
HHJ35_RS11985 2526537..2527190 - 654 WP_000045647.1 formate dehydrogenase-N subunit gamma -
HHJ35_RS11990 2527183..2528067 - 885 WP_001240584.1 formate dehydrogenase N subunit beta -
HHJ35_RS11995 2528080..2531127 - 3048 WP_011478186.1 formate dehydrogenase-N subunit alpha -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(4-92)

Antitoxin

Toxin-antitoxin system, antidote protein, HigA

(1-88)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10537.16 Da        Isoelectric Point: 7.3206

>T154967 WP_000605675.1 NZ_CP051714:2525746-2526024 [Escherichia coli]
MIMNFRHKGLRDLFLLGKTSGVIPTQVKRLRHRLAVIDAACCLADIDMPGYRLHPLSGDRDGIWAISVSGNWRITFEFVN
GDAYILDYEDYH

Download         Length: 279 bp

>T154967 NZ_CP068555:c3963361-3963209 [Clostridioides difficile]
ATGGATAATTTTTTACAAGGTATATTAGCAAGTTTAGTTGCCAGTTTAATAGTTTACTTAACTAGTAAGTTATTTAAAAA
AGTAAAAAGCCACTCTGGCAGGAGTGACTTTAGTTTTGAACTAGAAATCAAGTTCAAAAAGAATAAACATTAG

Antitoxin


Download         Length: 95 a.a.        Molecular weight: 10401.08 Da        Isoelectric Point: 8.8567

>AT154967 WP_000781370.1 NZ_CP051714:2526024-2526308 [Escherichia coli]
MKMANHPRPGDIIQESLDELNVSLREFARAMEIAPSTASRLLTGKAALTPEMAIKLSVVIGSSPQMWLNLQNAWSLAEAE
KTVDVSRLRRLVTQ

Download         Length: 285 bp

>AT154967 NZ_CP068555:3963165-3963265 [Clostridioides difficile]
AAGAAGAACTACAATCTATTTAGACGTAGAGTGAAGTTCAAATACTAATGTTTATTCTTTTTGAACTTGATTTCTAGTTC
AAAACTAAAGTCACTCCTGCC

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S1Q1V8

Antitoxin

Source ID Structure
AlphaFold DB A0A829CUG6

References