Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-YefM
Location 1902887..1903389 Replicon chromosome
Accession NZ_CP051714
Organism Escherichia coli strain SCU-122

Toxin (Protein)


Gene name yoeB Uniprot ID A0A0H2Z0A6
Locus tag HHJ35_RS09020 Protein ID WP_000767826.1
Coordinates 1903135..1903389 (+) Length 85 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID S1Q063
Locus tag HHJ35_RS09015 Protein ID WP_001259255.1
Coordinates 1902887..1903138 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HHJ35_RS08990 1898065..1899132 - 1068 WP_000080128.1 bifunctional histidinol-phosphatase/imidazoleglycerol-phosphate dehydratase HisB -
HHJ35_RS08995 1899132..1900202 - 1071 WP_000108997.1 histidinol-phosphate transaminase -
HHJ35_RS09000 1900199..1901503 - 1305 WP_001350692.1 histidinol dehydrogenase -
HHJ35_RS09005 1901509..1902408 - 900 WP_000131782.1 ATP phosphoribosyltransferase -
HHJ35_RS09010 1902554..1902604 - 51 WP_001364200.1 his operon leader peptide -
HHJ35_RS09015 1902887..1903138 + 252 WP_001259255.1 YoeB-YefM toxin-antitoxin system antitoxin YefM Antitoxin
HHJ35_RS09020 1903135..1903389 + 255 WP_000767826.1 type II toxin-antitoxin system mRNA interferase toxin YoeB Toxin
HHJ35_RS09025 1903472..1904296 + 825 WP_000754737.1 SDR family oxidoreductase -
HHJ35_RS09030 1904342..1905271 + 930 WP_000803363.1 LysR family transcriptional regulator -
HHJ35_RS09035 1905486..1905548 + 63 WP_010723108.1 membrane protein YoeI -
HHJ35_RS09040 1905538..1906896 + 1359 WP_000019194.1 putrescine/proton symporter PlaP -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(5-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-73)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 10195.64 Da        Isoelectric Point: 8.0353

>T154956 WP_000767826.1 NZ_CP051714:1903135-1903389 [Escherichia coli]
VKLIWSEESWDDYLYWQETDKRIVKKINELIKDTRRTPFEGKGKPEPLKHNLSGFWSRRIIEEHRLVYAVTDDSLLIAAC
RYHY

Download         Length: 255 bp

>T154956 NZ_CP068547:468561-468863 [Tamlana sp. s12]
ATGAGTAAAAACAAATATCGAATAAGCAAACAAGCGATTGATGATTTAAATGATATTTGGGTATATACTTTTCACAAATG
GTCTAAAGAACAAGCTGACAGATATTACGACTTGATAATCGGAGAGATTGAATTTATAGCGGACAACTATTTAATTGGAA
AATCGGCTGAACAAACTCGAAAAAACTATCGCGTAACAAAAATCAAATCGCATCTGATTTTTTACAGAAAGGTTGAGAAT
GAAATTGTCGAAATCGTTAGAATTTTACATATAAGAATGGATATTAAAAAACGACTGATATAA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9307.58 Da        Isoelectric Point: 4.7954

>AT154956 WP_001259255.1 NZ_CP051714:1902887-1903138 [Escherichia coli]
MRTISYSEARQNLSATMMKAVEDHAPILITRQNGEACVLMSLEEYNSLEETAYLLRSPANARRLMDSIDSLKSGKGTEKD
IIE

Download         Length: 252 bp

>AT154956 NZ_CP068547:468322-468564 [Tamlana sp. s12]
ATGGGAAAAAACACATCAATATCACTCGGAAATCATTTTGAGGAATTTATCAGAGAAGAAGTAAAATCAGGCAGATATGG
TTCGGTAAGCGAAGTTATCCGTTCTGCATTACGTTTGCTGGAACGTGAAGAAAAAAAGGAAAGAGAATTAATTAAAGCAC
TCGAAGTAGGTGAAAATAGTGGTTTTATTGAAAATTTTGACCCAAAACAAAACCTGACTGATTTACATCGCAAACACTTA
TGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H2Z0A6

Antitoxin

Source ID Structure
PDB 2A6Q
AlphaFold DB A0A7U9LNR0

References