Detailed information of TA system TA154948

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): ldrD-rdlD/Ldr(toxin)
• Location: 4928488..4928709
• Replicon: chromosome
• Accession: NZ_CP051711
• Organism: Escherichia coli strain SCU-123

Toxin (Protein)

• Gene name: ldrD
• Uniprot ID: S1PGT3
• Locus tag: HHJ36_RS23660
• Protein ID: WP_000170954.1
• Coordinates: 4928488..4928595 (-)
• Length: 36 a.a.

Antitoxin (RNA)

Gene name	rdlD
Locus tag	-
Coordinates	4928648..4928709 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HHJ36_RS23635	4924333..4925415	+	1083	WP_000804726.1	peptide chain release factor 1	-
HHJ36_RS23640	4925415..4926248	+	834	WP_000456474.1	peptide chain release factor N(5)-glutamine methyltransferase	-
HHJ36_RS23645	4926245..4926637	+	393	WP_000200375.1	invasion regulator SirB2	-
HHJ36_RS23650	4926641..4927450	+	810	WP_001257054.1	invasion regulator SirB1	-
HHJ36_RS23655	4927486..4928340	+	855	WP_000811065.1	3-deoxy-8-phosphooctulonate synthase	-
HHJ36_RS23660	4928488..4928595	-	108	WP_000170954.1	type I toxin-antitoxin system toxin Ldr family protein	Toxin
-	4928648..4928709	+	62	NuclAT_12	-	Antitoxin
-	4928648..4928709	+	62	NuclAT_12	-	Antitoxin
-	4928648..4928709	+	62	NuclAT_12	-	Antitoxin
-	4928648..4928709	+	62	NuclAT_12	-	Antitoxin
-	4928648..4928709	+	62	NuclAT_13	-	Antitoxin
-	4928648..4928709	+	62	NuclAT_13	-	Antitoxin
-	4928648..4928709	+	62	NuclAT_13	-	Antitoxin
-	4928648..4928709	+	62	NuclAT_13	-	Antitoxin
-	4928648..4928709	+	62	NuclAT_14	-	Antitoxin
-	4928648..4928709	+	62	NuclAT_14	-	Antitoxin
-	4928648..4928709	+	62	NuclAT_14	-	Antitoxin
-	4928648..4928709	+	62	NuclAT_14	-	Antitoxin
-	4928648..4928709	+	62	NuclAT_15	-	Antitoxin
-	4928648..4928709	+	62	NuclAT_15	-	Antitoxin
-	4928648..4928709	+	62	NuclAT_15	-	Antitoxin
-	4928648..4928709	+	62	NuclAT_15	-	Antitoxin
-	4928648..4928709	+	62	NuclAT_16	-	Antitoxin
-	4928648..4928709	+	62	NuclAT_16	-	Antitoxin
-	4928648..4928709	+	62	NuclAT_16	-	Antitoxin
-	4928648..4928709	+	62	NuclAT_16	-	Antitoxin
-	4928648..4928709	+	62	NuclAT_17	-	Antitoxin
-	4928648..4928709	+	62	NuclAT_17	-	Antitoxin
-	4928648..4928709	+	62	NuclAT_17	-	Antitoxin
-	4928648..4928709	+	62	NuclAT_17	-	Antitoxin
-	4928648..4928710	+	63	NuclAT_10	-	-
-	4928648..4928710	+	63	NuclAT_10	-	-
-	4928648..4928710	+	63	NuclAT_10	-	-
-	4928648..4928710	+	63	NuclAT_10	-	-
-	4928648..4928710	+	63	NuclAT_11	-	-
-	4928648..4928710	+	63	NuclAT_11	-	-
-	4928648..4928710	+	63	NuclAT_11	-	-
-	4928648..4928710	+	63	NuclAT_11	-	-
-	4928648..4928710	+	63	NuclAT_6	-	-
-	4928648..4928710	+	63	NuclAT_6	-	-
-	4928648..4928710	+	63	NuclAT_6	-	-
-	4928648..4928710	+	63	NuclAT_6	-	-
-	4928648..4928710	+	63	NuclAT_7	-	-
-	4928648..4928710	+	63	NuclAT_7	-	-
-	4928648..4928710	+	63	NuclAT_7	-	-
-	4928648..4928710	+	63	NuclAT_7	-	-
-	4928648..4928710	+	63	NuclAT_8	-	-
-	4928648..4928710	+	63	NuclAT_8	-	-
-	4928648..4928710	+	63	NuclAT_8	-	-
-	4928648..4928710	+	63	NuclAT_8	-	-
-	4928648..4928710	+	63	NuclAT_9	-	-
-	4928648..4928710	+	63	NuclAT_9	-	-
-	4928648..4928710	+	63	NuclAT_9	-	-
-	4928648..4928710	+	63	NuclAT_9	-	-
-	4928648..4928711	+	64	NuclAT_18	-	-
-	4928648..4928711	+	64	NuclAT_18	-	-
-	4928648..4928711	+	64	NuclAT_18	-	-
-	4928648..4928711	+	64	NuclAT_18	-	-
-	4928648..4928711	+	64	NuclAT_19	-	-
-	4928648..4928711	+	64	NuclAT_19	-	-
-	4928648..4928711	+	64	NuclAT_19	-	-
-	4928648..4928711	+	64	NuclAT_19	-	-
-	4928648..4928711	+	64	NuclAT_20	-	-
-	4928648..4928711	+	64	NuclAT_20	-	-
-	4928648..4928711	+	64	NuclAT_20	-	-
-	4928648..4928711	+	64	NuclAT_20	-	-
-	4928648..4928711	+	64	NuclAT_21	-	-
-	4928648..4928711	+	64	NuclAT_21	-	-
-	4928648..4928711	+	64	NuclAT_21	-	-
-	4928648..4928711	+	64	NuclAT_21	-	-
-	4928648..4928711	+	64	NuclAT_22	-	-
-	4928648..4928711	+	64	NuclAT_22	-	-
-	4928648..4928711	+	64	NuclAT_22	-	-
-	4928648..4928711	+	64	NuclAT_22	-	-
-	4928648..4928711	+	64	NuclAT_23	-	-
-	4928648..4928711	+	64	NuclAT_23	-	-
-	4928648..4928711	+	64	NuclAT_23	-	-
-	4928648..4928711	+	64	NuclAT_23	-	-
HHJ36_RS23665	4929001..4930101	-	1101	WP_001313768.1	sodium-potassium/proton antiporter ChaA	-
HHJ36_RS23670	4930371..4930601	+	231	WP_001146444.1	putative cation transport regulator ChaB	-
HHJ36_RS23675	4930759..4931454	+	696	WP_000632706.1	glutathione-specific gamma-glutamylcyclotransferase	-
HHJ36_RS23680	4931498..4931851	-	354	WP_001169659.1	DsrE/F sulfur relay family protein YchN	-
HHJ36_RS23685	4932036..4933430	+	1395	WP_000086194.1	inverse autotransporter invasin YchO	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Type I toxin-antitoxin system, toxin Ldr (1-35)

Sequences

Toxin

Protein

• Length: 36 a.a.
• Molecular weight: 3983.80 Da
• Isoelectric Point: 11.4779

>T154948 WP_000170954.1 NZ_CP051711:c4928595-4928488 [Escherichia coli]
MTLAQFAMIFWHDLAAPILAGIITAAIVGWWRNRK

Nucleotide

• Length: 108 bp

>T154948 NZ_CP068444:712393-712881 [Klebsiella quasipneumoniae]
ATGATCTCCGCTCCAGAACCGCTTCATACCGGGCATATTCTTACCCCGTTTTGTTGCGGCGTGGATTCTATGGATAACTG
GCTAAAACAGCGGGCGATGAAGAACCAGCTTTCTGGCGCATCCCGCACGTTCGTCTGCTGTGACGATGCGAAGGTAATGG
CGTACTACTCGCTGGCTTCAAGTGCTGTGACGACAAATACTGCGCCCGGTCGCTTCCGTCGCAATATGCCTGACCCGATC
CCGGTTGTGGTGCTGGGACGTCTGGCGGTGGATCGGTCGCTACATGGGCATGGCGTAGGTCGGGCGCTGGTGAGGGATGC
CGGACTGCGGGTGATTCAGGTGGCGGAGACTATCGGCATTCGTGGGATGTTGGTCCATGCCTTGTCGGATGAAGCGCGGG
AGTTTTACCTGCGGGTGGGGTTTGAGCCGTCGCCGATGGATCCGATGATGTTGATGGTGACATTGGGGGATTTGGTGGAG
AGTATTTAG

Antitoxin

Nucleotide

• Length: 62 bp

>AT154948 NZ_CP051711:4928648-4928709 [Escherichia coli]
TGGTTCAAGATTAGCCCCCGTTCTGTTGTCAGGTTTTACCTCTCAACGTGCGGGGGTTTTCT

Structures

Toxin

• AlphaFold DB: A0A7U9LPE9

Antitoxin