Detailed information of TA system TA154942

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): hok-sok/-
• Location: 3707655..3707913
• Replicon: chromosome
• Accession: NZ_CP051711
• Organism: Escherichia coli strain SCU-123

Toxin (Protein)

• Gene name: hokC
• Uniprot ID: S1NX00
• Locus tag: HHJ36_RS17745
• Protein ID: WP_000809168.1
• Coordinates: 3707655..3707807 (-)
• Length: 51 a.a.

Antitoxin (RNA)

Gene name	sokC
Locus tag	-
Coordinates	3707856..3707913 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HHJ36_RS17725	3702900..3703613	-	714	WP_001102393.1	acidic protein MsyB	-
HHJ36_RS17730	3703639..3704043	-	405	WP_000843687.1	DUF2541 family protein	-
HHJ36_RS17735	3704415..3706331	+	1917	WP_000516135.1	molecular chaperone DnaK	-
HHJ36_RS17740	3706420..3707550	+	1131	WP_001118464.1	molecular chaperone DnaJ	-
HHJ36_RS17745	3707655..3707807	-	153	WP_000809168.1	type I toxin-antitoxin system toxin MokC	Toxin
-	3707856..3707913	+	58	-	-	Antitoxin
HHJ36_RS17750	3708419..3709180	+	762	WP_001274823.1	hypothetical protein	-
HHJ36_RS17755	3709200..3710693	+	1494	WP_001350775.1	sulfatase-like hydrolase/transferase	-
HHJ36_RS17760	3710822..3712081	+	1260	WP_000494924.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Hok/gef cell toxic protein (6-47)

Sequences

Toxin

Protein

• Length: 51 a.a.
• Molecular weight: 5501.57 Da
• Isoelectric Point: 7.1312

>T154942 WP_000809168.1 NZ_CP051711:c3707807-3707655 [Escherichia coli]
MKQHKAMIVALIVICITAVVAALVTRKDLCEVHIRTGQTEVAVFTAYESE

Nucleotide

• Length: 153 bp

>T154942 NZ_CP068440:c2562642-2562289 [Pantoea agglomerans]
GTGTGGATGATTAAAACGACGGAGAGGTTTGATCGCTGGTTTACCTTGCTTAATGAGAGCGATCGCGCCTGCGTACTGGC
AGCATTAATTGTGTTGCGCGAAAAAGAGCCGGGGTTGTCCAGGCCATACGCGGATACGTTAAAAGGCTCTGTTTATATCA
ACATGAAAGAGCTGCGTATTCAGAGTCGCGGTGATCCGATAAGGGCTTTCTTTGCTTTTGACCCAAACCGAACGGCGATT
GTGCTTTGTGCCGGAAATAAGGTGGGCAATGAAAAGCGTTTTTATCGGGAGATGCTTCCGGTTGCCGATCGGGAATTCAC
ACACTGGCTGAATGTCTTTAAAGATGAGGAGTAA

Antitoxin

Nucleotide

• Length: 58 bp

>AT154942 NZ_CP051711:3707856-3707913 [Escherichia coli]
GTTCTGCATATAGGGGGCCTCGGGTTGATGGTAAAATATCACTCGGGGCTTTTCTCTA

Structures

Toxin

• AlphaFold DB: S1NX00

Antitoxin