154932

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-YefM
Location 827496..827998 Replicon chromosome
Accession NZ_CP051711
Organism Escherichia coli strain SCU-123

Toxin (Protein)


Gene name yoeB Uniprot ID A0A0H2Z0A6
Locus tag HHJ36_RS03935 Protein ID WP_000767826.1
Coordinates 827496..827750 (-) Length 85 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID -
Locus tag HHJ36_RS03940 Protein ID WP_071686836.1
Coordinates 827747..827998 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HHJ36_RS03915 823989..825347 - 1359 WP_000019194.1 putrescine/proton symporter PlaP -
HHJ36_RS03920 825337..825399 - 63 WP_010723108.1 membrane protein YoeI -
HHJ36_RS03925 825614..826543 - 930 WP_000803363.1 LysR family transcriptional regulator -
HHJ36_RS03930 826589..827413 - 825 WP_000754737.1 SDR family oxidoreductase -
HHJ36_RS03935 827496..827750 - 255 WP_000767826.1 type II toxin-antitoxin system mRNA interferase toxin YoeB Toxin
HHJ36_RS03940 827747..827998 - 252 WP_071686836.1 YoeB-YefM toxin-antitoxin system antitoxin YefM Antitoxin
HHJ36_RS03945 828281..828331 + 51 WP_001364200.1 his operon leader peptide -
HHJ36_RS03950 828477..829376 + 900 WP_000131782.1 ATP phosphoribosyltransferase -
HHJ36_RS03955 829382..830686 + 1305 WP_001350692.1 histidinol dehydrogenase -
HHJ36_RS03960 830683..831753 + 1071 WP_000108997.1 histidinol-phosphate transaminase -
HHJ36_RS03965 831753..832820 + 1068 WP_000080128.1 bifunctional histidinol-phosphatase/imidazoleglycerol-phosphate dehydratase HisB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(5-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-73)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 10195.64 Da        Isoelectric Point: 8.0353

>T154932 WP_000767826.1 NZ_CP051711:c827750-827496 [Escherichia coli]
VKLIWSEESWDDYLYWQETDKRIVKKINELIKDTRRTPFEGKGKPEPLKHNLSGFWSRRIIEEHRLVYAVTDDSLLIAAC
RYHY

Download         Length: 255 bp

>T154932 NZ_CP068435:c1093329-1092940 [Cupriavidus necator]
ATGAGCGTGCTCGTCGACACCTCTGTTTGGGTAGACCATTTCAAGAGCCGCAATGACGCACTGGTCAGCTTGCTCGTGTC
GGATCAAGCGCTGACCCACCCCATGGTCGTGGTTGAACTAGCTTGCGGGACGCCCCCGGCACCGCGTGCCCGGACACTCG
GCGACATCGGCCTGTTGCAGCCTGCAAGGCGGGCGAGCCTGGCAGAAGTGATGGCTTTCATCGAGCAAGAGAATCTGTAT
GGACTGGGCTGCGGCCTGGTGGATGTCTCATTGCTGGCTTCCACTTTGATTACGCCAGGCGCACGGCTATGGACACTGGA
CCAGCGTCTCAACGACTTGTCAGCGCGTTTTGGTGTGGCGCATCGACCCAGGCTTCACCAGGTCACCTGA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9333.62 Da        Isoelectric Point: 4.7954

>AT154932 WP_071686836.1 NZ_CP051711:c827998-827747 [Escherichia coli]
MRTISYSEARQNLSATMMKAVEDHAPILITRQNGEPCVLMSLEEYNSLEETAYLLRSPANARRLMDSIDSLKSGKGTEKD
IIE

Download         Length: 252 bp

>AT154932 NZ_CP068435:c1093532-1093326 [Cupriavidus necator]
ATGCGCACGACCGTCACGATCGACGACGCCCTGTATGAACAAGCACTAGAGGTGGCTGACCCTGGCATGGACAAATCTGA
CCTTTTTCGTGAGGCAATCAAGACTTTCGTTCGGGTTCAAGCGGCCAAGCGTCTCGCGGCACTGGGTGGCGCCGCCCCCA
ACATGGAAGACGCGCCACGTCGCCGTATGGAACCTGAAGCAAAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H2Z0A6

Antitoxin

Source ID Structure

References