Detailed information of TA system TA154911

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): symER/SymE(toxin)
• Location: 3991724..3992133
• Replicon: chromosome
• Accession: NZ_CP051706
• Organism: Escherichia coli strain SCU-124

Toxin (Protein)

• Gene name: symE
• Uniprot ID: A0A3L4RJH9
• Locus tag: HHJ37_RS19290
• Protein ID: WP_001357525.1
• Coordinates: 3991795..3992133 (+)
• Length: 113 a.a.

Antitoxin (RNA)

Gene name	symR
Locus tag	-
Coordinates	3991724..3991800 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HHJ37_RS19270	3987791..3987994	+	204	WP_000467859.1	YbdD/YjiX family protein	-
HHJ37_RS19275	3988005..3988961	+	957	WP_001295525.1	GTPase	-
HHJ37_RS19280	3989292..3991142	+	1851	WP_000190966.1	AAA family ATPase	-
HHJ37_RS19285	3991287..3991580	+	294	WP_000926091.1	DUF3387 domain-containing protein	-
-	3991724..3991800	-	77	NuclAT_12	-	Antitoxin
-	3991724..3991800	-	77	NuclAT_12	-	Antitoxin
-	3991724..3991800	-	77	NuclAT_12	-	Antitoxin
-	3991724..3991800	-	77	NuclAT_12	-	Antitoxin
-	3991724..3991800	-	77	NuclAT_13	-	Antitoxin
-	3991724..3991800	-	77	NuclAT_13	-	Antitoxin
-	3991724..3991800	-	77	NuclAT_13	-	Antitoxin
-	3991724..3991800	-	77	NuclAT_13	-	Antitoxin
HHJ37_RS19290	3991795..3992133	+	339	WP_001357525.1	endoribonuclease SymE	Toxin
HHJ37_RS19295	3992175..3992339	-	165	WP_001357524.1	DUF1127 domain-containing protein	-
HHJ37_RS19300	3992517..3992693	+	177	WP_001523889.1	GntR family transcriptional regulator	-
HHJ37_RS19305	3992823..3993743	-	921	WP_001523888.1	Rpn family recombination-promoting nuclease/putative transposase	-
HHJ37_RS19310	3993928..3995208	+	1281	WP_001523887.1	DUF445 domain-containing protein	-
HHJ37_RS19315	3995326..3996477	+	1152	WP_001298064.1	2-hydroxyacyl-CoA dehydratase subunit D	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin SymE-like (20-71)

Sequences

Toxin

Protein

• Length: 113 a.a.
• Molecular weight: 12314.03 Da
• Isoelectric Point: 7.8234

>T154911 WP_001357525.1 NZ_CP051706:3991795-3992133 [Escherichia coli]
MTDTHSIAQPFEAEVSPANNRQLTVSYASRYPDYSRIPAITLKGQWLEAAGFTTGTAVDVKVMEGCIVLTAQPPAAEESE
LMQSLRQVCKLSARKQRQVQDFIGVISSKTPR

Nucleotide

• Length: 339 bp

>T154911 NZ_CP068394:c2242387-2242133 [Escherichia coli]
GTGAAACTAATCTGGTCTGAGGAATCATGGGATGATTATCTGTACTGGCAGGAAACAGATAAGCGAATTGTTAAAAAGAT
CAATGAACTTATCAAAGATACCCGCAGAACACCATTTGAAGGTAAGGGGAAACCAGAACCCCTGAAACATAATTTGTCAG
GTTTCTGGTCCCGACGCATTACAGAGGAGCACCGTCTGGTATACGCGGTTACTGATGATTCACTGCTCATTGCAGCATGT
CGTTATCATTATTGA

Antitoxin

Nucleotide

• Length: 77 bp

>AT154911 NZ_CP051706:c3991800-3991724 [Escherichia coli]
AGTCATAACTGCTATTCCCTATAAATAGTGATTGTGATTAGCGGTGCGGGTGTGTTGGCGCACATCCGCACCGCGCT

Structures

Toxin

• AlphaFold DB: A0A3L4RJH9

Antitoxin