Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-YefM
Location 1849133..1849635 Replicon chromosome
Accession NZ_CP051706
Organism Escherichia coli strain SCU-124

Toxin (Protein)


Gene name yoeB Uniprot ID E2QNP2
Locus tag HHJ37_RS08700 Protein ID WP_000767819.1
Coordinates 1849381..1849635 (+) Length 85 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID E2QNP3
Locus tag HHJ37_RS08695 Protein ID WP_001259253.1
Coordinates 1849133..1849384 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HHJ37_RS08670 1844311..1845378 - 1068 WP_000080128.1 bifunctional histidinol-phosphatase/imidazoleglycerol-phosphate dehydratase HisB -
HHJ37_RS08675 1845378..1846448 - 1071 WP_001524973.1 histidinol-phosphate transaminase -
HHJ37_RS08680 1846445..1847749 - 1305 WP_001524971.1 histidinol dehydrogenase -
HHJ37_RS08685 1847755..1848654 - 900 WP_000131782.1 ATP phosphoribosyltransferase -
HHJ37_RS08690 1848800..1848850 - 51 WP_001364200.1 his operon leader peptide -
HHJ37_RS08695 1849133..1849384 + 252 WP_001259253.1 YoeB-YefM toxin-antitoxin system antitoxin YefM Antitoxin
HHJ37_RS08700 1849381..1849635 + 255 WP_000767819.1 type II toxin-antitoxin system mRNA interferase toxin YoeB Toxin
HHJ37_RS08705 1849718..1850542 + 825 WP_000754733.1 SDR family oxidoreductase -
HHJ37_RS08710 1850588..1851517 + 930 WP_000803366.1 LysR family transcriptional regulator -
HHJ37_RS08715 1851732..1851794 + 63 WP_010723108.1 membrane protein YoeI -
HHJ37_RS08720 1851784..1853142 + 1359 WP_000019197.1 putrescine/proton symporter PlaP -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(2-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-72)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 10110.53 Da        Isoelectric Point: 7.2749

>T154897 WP_000767819.1 NZ_CP051706:1849381-1849635 [Escherichia coli]
VKLIWSEESWDDYLYWQEADKRIVKKINELIKDTRRTPFEGKGKPEPLKHNLSGFWSRRITEEHLLVYAVTDDSLLIAAC
RYHY

Download         Length: 255 bp

>T154897 NZ_CP068390:c2335788-2335495 [Pseudomonas chlororaphis subsp. aurantiaca]
ATGGATTACGAGATCCTGCAGACGACCGTCTTTGCCCAATGGCACACCACACAACGGGACCTGCGCGCCAGGATAGCCAT
CGCTCGGCGTATCGAGCGGGCTTCGGCGGGCAACCTGGGCGATGTGAAAAACTTCGGCGGCGGTCTCTCGAAAATGCGCG
TGAACACAGGCGCCGGCTACCACCTCTATTTCACGGGTCGCGGCAATACCCTCATCGTCCTGCTGCTGGGTGGCGACAAG
TCCAGCCAGCCTGCCGATATCTGCCAGGCCCGTTCCCTGGCCAAGGAGTTCTGA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9365.62 Da        Isoelectric Point: 4.6127

>AT154897 WP_001259253.1 NZ_CP051706:1849133-1849384 [Escherichia coli]
MRTISYSEARQNLSATMMKAVEDHAPILITRQNGEACVLMSLEEYNSLEETAYLLRSPANARRLMDSIDSLKSDKGTEKD
IIE

Download         Length: 252 bp

>AT154897 NZ_CP068390:c2335493-2335203 [Pseudomonas chlororaphis subsp. aurantiaca]
ATGTCCGACACACTGGTTCCCTTCGACATCGCCGCCCTGCTCGACAGCGACCAGGCGATCAGCGAATACCTGTCCCAGGT
CCTGGCCGATGGCGATACCGACGAACTGATCCGCGCCCTGGGGCACGTCGCCAGGGCCCGGGGCATGACGCAGATTGCCA
AGACCACCGGCCAGGGCCGGGCCAGCCTCTACAAGGCTTTTGCCCCGGGGGCCAAGCCGCGCTTCGATACCGTGGTCAAG
GTCATGCGCGCGCTGGGCCTGCAGCTGTGCACCACTGTGTCCCGAGGCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB E2QNP2

Antitoxin

Source ID Structure
AlphaFold DB E2QNP3

References