Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 4428988..4429715 Replicon chromosome
Accession NZ_CP051700
Organism Escherichia coli strain SCU-125

Toxin (Protein)


Gene name higB Uniprot ID A0A8E0MHE9
Locus tag HHJ38_RS21600 Protein ID WP_021524447.1
Coordinates 4428988..4429299 (+) Length 104 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag HHJ38_RS21605 Protein ID WP_000126304.1
Coordinates 4429296..4429715 (+) Length 140 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HHJ38_RS21570 4424129..4425838 + 1710 WP_001288134.1 formate hydrogenlyase subunit HycE -
HHJ38_RS21575 4425848..4426390 + 543 WP_000493785.1 formate hydrogenlyase subunit HycF -
HHJ38_RS21580 4426390..4427157 + 768 WP_000067399.1 formate hydrogenlyase subunit HycG -
HHJ38_RS21585 4427154..4427564 + 411 WP_001291913.1 formate hydrogenlyase assembly protein HycH -
HHJ38_RS21590 4427557..4428027 + 471 WP_000132956.1 hydrogenase maturation peptidase HycI -
HHJ38_RS21595 4428070..4428825 + 756 WP_001314074.1 hypothetical protein -
HHJ38_RS21600 4428988..4429299 + 312 WP_021524447.1 type II toxin-antitoxin system HigB family toxin Toxin
HHJ38_RS21605 4429296..4429715 + 420 WP_000126304.1 helix-turn-helix domain-containing protein Antitoxin
HHJ38_RS21610 4429807..4430235 - 429 WP_000536064.1 hypothetical protein -
HHJ38_RS21615 4430620..4431147 + 528 WP_001078777.1 electron transport protein HydN -
HHJ38_RS21620 4431300..4433552 + 2253 WP_169063614.1 carbamoyltransferase HypF -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, mRNA interferase HigB

(22-93)

Antitoxin

Cro/C1-type helix-turn-helix domain

(85-138)


Sequences

Toxin        


Download         Length: 104 a.a.        Molecular weight: 12428.24 Da        Isoelectric Point: 9.7074

>T154891 WP_021524447.1 NZ_CP051700:4428988-4429299 [Escherichia coli]
MHIISKAPFEECARKYPNDALALQALYRVIKETDFSTPEEMRTAFPNLDNFKYRNKWYVLDVGGNKLRVIAYINFVNKRF
FVKHITNHAEYDKLTRYYRENKE

Download         Length: 312 bp

>T154891 NZ_CP068388:73701-74129 [Salmonella enterica subsp. enterica serovar Gallinarum/Pullorum]
ATGAAACAGCCACGTACGAAGACCTATATGCTCGATACCTGTATCTGTTCGTTCATCATGCGCGAGAAGTCGGAAGCGGT
GCTGAAGCGCCTTGAGCAGGCGGTGCTGCGCGGCCACCGTATCGTGATCTCGGCCATCACCTACTCCGAGATGCGCTTCG
GCGCCACCGGACCTAAGGCCTCGCCGCGTCTCGTCCAGCTGGTCGACGCGTTCTGCGCCCGCCTCGATGCCATCCTGCCC
TGGGATCGCGCTGCGGTAGACGCCACCACGGAGATTAAGGTGGCACTGTGCCTCGCCGGGACGCCGATCGGTCCGAACGA
CACGGCGATTGCCGGGCATGCCATCGCCGCCGGTGCCGTGCTGGTGACGAATAATACGCGGGAATTTGAGCGGGTACCGG
GCCTGGTACTGGAAGACTGGGTAAGTTAA

Antitoxin


Download         Length: 140 a.a.        Molecular weight: 15474.50 Da        Isoelectric Point: 4.4596

>AT154891 WP_000126304.1 NZ_CP051700:4429296-4429715 [Escherichia coli]
MTANAVRAVKATRELVNAVPFLGGSDSEDDYREALELVEYLIEEDDTNPLIDFLTSRIAEYENNNEKFAEFDKAVAAMPV
GVALLRTLIDQHNLTYADLKNEIGSKSLVSQILSGQRSLTISHIKALSARFGVKPEWFL

Download         Length: 420 bp

>AT154891 NZ_CP068388:73474-73704 [Salmonella enterica subsp. enterica serovar Gallinarum/Pullorum]
ATGAGAACCGTATCCATTTTTAAAAACGGCAACAACCGCGCCATCCGCCTTCCACGCGATCTGGATTTTGAGGGGGTGAG
CGAGCTGGAAATCGTCCGGGAAGGGGACAGCATCATCCTGCGCCCTGTCCGGCCGACCTGGGGCTCGTTCGCGCAGCTCG
AAAAAGCTGACCCGGACTTTATGGCGGAGCGCGAGGACGTTGTCAGCGACGAAGGACGCTTTGAGCTATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References