Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 790592..791154 Replicon chromosome
Accession NZ_CP051700
Organism Escherichia coli strain SCU-125

Toxin (Protein)


Gene name higB Uniprot ID S1Q1V8
Locus tag HHJ38_RS04065 Protein ID WP_000605675.1
Coordinates 790592..790870 (+) Length 93 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID S1PAQ1
Locus tag HHJ38_RS04070 Protein ID WP_000781370.1
Coordinates 790870..791154 (+) Length 95 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HHJ38_RS04040 786178..786609 - 432 WP_000152305.1 peroxiredoxin OsmC -
HHJ38_RS04045 786954..787169 + 216 WP_000495766.1 biofilm-dependent modulation protein -
HHJ38_RS04050 787271..787408 + 138 WP_000841554.1 stationary-phase-induced ribosome-associated protein -
HHJ38_RS04055 787565..789262 + 1698 WP_000433464.1 malate dehydrogenase -
HHJ38_RS04060 789396..790406 + 1011 WP_000642412.1 alcohol dehydrogenase AdhP -
HHJ38_RS04065 790592..790870 + 279 WP_000605675.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
HHJ38_RS04070 790870..791154 + 285 WP_000781370.1 HigA family addiction module antidote protein Antitoxin
HHJ38_RS04075 791383..792036 - 654 WP_000045647.1 formate dehydrogenase-N subunit gamma -
HHJ38_RS04080 792029..792913 - 885 WP_001240584.1 formate dehydrogenase N subunit beta -
HHJ38_RS04085 792926..795973 - 3048 WP_077634457.1 formate dehydrogenase-N subunit alpha -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(4-92)

Antitoxin

Toxin-antitoxin system, antidote protein, HigA

(1-88)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10537.16 Da        Isoelectric Point: 7.3206

>T154878 WP_000605675.1 NZ_CP051700:790592-790870 [Escherichia coli]
MIMNFRHKGLRDLFLLGKTSGVIPTQVKRLRHRLAVIDAACCLADIDMPGYRLHPLSGDRDGIWAISVSGNWRITFEFVN
GDAYILDYEDYH

Download         Length: 279 bp

>T154878 NZ_CP068386:549757-550068 [Salmonella enterica subsp. enterica serovar Gallinarum/Pullorum]
ATGCAATTTATAGAAACGGAACTCTTTACTGAAGATGTTAAAAAACTGCTCGATGAGGATGAATACCATAAGCTTCAGGT
TTTTATGGCTCAGCATCCAGATTGTGGTGATGTCATTCAGGAAACGGGCGGCCTGAGAAAAATGCGCTGGGGAGCGCGAG
GCAAAGGAAAGCGTAGTGGCGTGCGAATTATCTATTTTCACCGTAGTCAACGGTATGAGATTCGCTTGCTTCTGATTTAT
CAAAAAGGCATTAAAGATGATCTCACGCCGCAGGAAAAAGCGGTGCTTCGTATGCTGAATGAGAGGTGGTAG

Antitoxin


Download         Length: 95 a.a.        Molecular weight: 10401.08 Da        Isoelectric Point: 8.8567

>AT154878 WP_000781370.1 NZ_CP051700:790870-791154 [Escherichia coli]
MKMANHPRPGDIIQESLDELNVSLREFARAMEIAPSTASRLLTGKAALTPEMAIKLSVVIGSSPQMWLNLQNAWSLAEAE
KTVDVSRLRRLVTQ

Download         Length: 285 bp

>AT154878 NZ_CP068386:550069-550359 [Salmonella enterica subsp. enterica serovar Gallinarum/Pullorum]
ATGGATAAAGTGTTATTTGAGCGATTAACTCAAAGTATGTCTCAAATGAATGAAATCATTGAAGGGACCCGTGAGCCTTC
TCGTACCTTTCATATTGATGCAATGAAGATTAAAGAAATACGGCAGGCATCTGGGTTGTCGCAATCTAAGTTTGCAGAAC
TGATTTCGGTCAACGTGGATACGCTGCGCAACTGGGAGCAAGGAAGACGTTCACCGACAGGGCCAGCCAAAGCGTTACTT
CGCGCCATTGCCAACGACCCGAGAAACGTTATACAAGCATTGCGTTATTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S1Q1V8

Antitoxin

Source ID Structure
PDB 2ICT
PDB 2ICP
AlphaFold DB A0A829CUG6

References