Detailed information of TA system TA154859

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): hok-sok/-
• Location: 4018734..4018992
• Replicon: chromosome
• Accession: NZ_CP051698
• Organism: Escherichia coli strain SCU-152

Toxin (Protein)

• Gene name: hokC
• Uniprot ID: S1NX00
• Locus tag: HHJ40_RS19220
• Protein ID: WP_000809168.1
• Coordinates: 4018734..4018886 (-)
• Length: 51 a.a.

Antitoxin (RNA)

Gene name	sokC
Locus tag	-
Coordinates	4018935..4018992 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HHJ40_RS19200	4013975..4014688	-	714	WP_001102383.1	acidic protein MsyB	-
HHJ40_RS19205	4014714..4015118	-	405	WP_000843559.1	DUF2541 family protein	-
HHJ40_RS19210	4015495..4017411	+	1917	WP_000516135.1	molecular chaperone DnaK	-
HHJ40_RS19215	4017500..4018630	+	1131	WP_001118464.1	molecular chaperone DnaJ	-
HHJ40_RS19220	4018734..4018886	-	153	WP_000809168.1	type I toxin-antitoxin system toxin MokC	Toxin
-	4018935..4018992	+	58	-	-	Antitoxin
HHJ40_RS19225	4019473..4020639	+	1167	WP_000681360.1	Na+/H+ antiporter NhaA	-
HHJ40_RS19230	4020705..4021604	+	900	WP_001300855.1	transcriptional activator NhaR	-
HHJ40_RS19235	4021643..4022601	-	959	Protein_3761	fimbrial family protein	-
HHJ40_RS19240	4022614..4023966	-	1353	Protein_3762	fimbria/pilus outer membrane usher protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Hok/gef cell toxic protein (6-47)

Sequences

Toxin

Protein

• Length: 51 a.a.
• Molecular weight: 5501.57 Da
• Isoelectric Point: 7.1312

>T154859 WP_000809168.1 NZ_CP051698:c4018886-4018734 [Escherichia coli]
MKQHKAMIVALIVICITAVVAALVTRKDLCEVHIRTGQTEVAVFTAYESE

Nucleotide

• Length: 153 bp

>T154859 NZ_CP068285:3445101-3446024 [Ralstonia syzygii subsp. celebesensis]
ATGAATACCACGGCCCCCAAGCATTCTGCGACATCCATCCGGGCGCGGCTCTTCAATCACGCCAAGGAGCGTGGTGACGA
TTTTCAACGCGTTTTGACACGCTACGCAATTGAGCGCCTTCTCTTCCGACTCAGTCAGACAGAAGCCGTCGAGCGCTATG
TGCTCAAGGGCGCCATGCTGTTTGTGACCTGGCCCGAGCACGTCTTTCGCCCATCCGGGGACCTTGATCTACTTGGCCAA
GGCAACCCTGACCCCGACGCGATCACCGAACTCTTCACCCGCATCTGCCAGGTCGACGTCGCGGACGACGGCATCGTTTT
CGAGCCAGCCACGCTGAAGGTCGAACCTGTGCGCGAAGCCGACAAGTACCAAGGGGTTCGATTGAGCCTCAAGGGCGAAC
TGGCCAAGGCGGTTATCCACGTGCAGGTTGACATCGGCTTCGGCGACTACGTCTACCCGCCGCCGAAGTACCACATCTTC
CCAAGCCTACTGCAGGATCTGCCCGCAGCGAACATCCTGATGTACCCACCCGAAACCGTGGTCGCCGAAAAATTCGAGGC
GATGATCCGCTTCGGGGAGGCAAACGGCAGGATCAAGGATTTTCACGACATGTGGGTCATGACCCGCACGTTCTCGTTTG
ATATGCCCACCTTGGTCGAAGCGGTCGGCGGAACACTCCGGCGCCGCGAAACTGCGATCCCGACTGAGATGCCGGCGGGC
CTTACCGAGACGTTCGCGAAGGTCGCCGAGGAGCGCGGCCTTTGGAGCGGCTTCCTGCGCCGAAACCCGCCGACCCTTCA
ACCGCCACCTTTCGCGGACCTGCAAGAGGAGCTACGGCGCTTCTTTGGCCCCGTCATCACCAACCTCGCGCTGCCGGAAG
GCGCCAAAGGCCGATGGGACCCAGATGCCGGAGCTTGGCGCTGA

Antitoxin

Nucleotide

• Length: 58 bp

>AT154859 NZ_CP051698:4018935-4018992 [Escherichia coli]
GTTCAGCATATAGGGGGCCTCGGGTTGATAGTAAAATATCACTCGGGGCTTTTCTCTA

Structures

Toxin

• AlphaFold DB: S1NX00

Antitoxin