Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) DinJ-YafQ (relBE)/YafQ-RelB
Location 3725731..3726272 Replicon chromosome
Accession NZ_CP051698
Organism Escherichia coli strain SCU-152

Toxin (Protein)


Gene name yafQ Uniprot ID U9XPG0
Locus tag HHJ40_RS17840 Protein ID WP_000615976.1
Coordinates 3725994..3726272 (+) Length 93 a.a.

Antitoxin (Protein)


Gene name dinJ Uniprot ID S1EWQ0
Locus tag HHJ40_RS17835 Protein ID WP_000729704.1
Coordinates 3725731..3725991 (+) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HHJ40_RS17810 3721514..3722299 - 786 WP_000207574.1 putative lateral flagellar export/assembly protein LafU -
HHJ40_RS17815 3722271..3723983 + 1713 Protein_3483 flagellar biosynthesis protein FlhA -
HHJ40_RS17820 3724088..3724366 + 279 WP_000598760.1 type II toxin-antitoxin system HicA family toxin -
HHJ40_RS17825 3724359..3724715 + 357 WP_001030484.1 type II toxin-antitoxin system HicB family antitoxin -
HHJ40_RS17830 3724772..3725545 - 774 WP_000543897.1 C40 family peptidase -
HHJ40_RS17835 3725731..3725991 + 261 WP_000729704.1 type II toxin-antitoxin system antitoxin DinJ Antitoxin
HHJ40_RS17840 3725994..3726272 + 279 WP_000615976.1 type II toxin-antitoxin system mRNA interferase toxin YafQ Toxin
HHJ40_RS17845 3726428..3727168 + 741 WP_001225679.1 murein L,D-transpeptidase -
HHJ40_RS17850 3727139..3727906 - 768 WP_000333380.1 class II glutamine amidotransferase -
HHJ40_RS17855 3728112..3728690 - 579 WP_000284050.1 D-sedoheptulose 7-phosphate isomerase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, YafQ-like toxin

(1-91)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(4-84)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10800.59 Da        Isoelectric Point: 10.0702

>T154858 WP_000615976.1 NZ_CP051698:3725994-3726272 [Escherichia coli]
MIQRDIEYSGQFSKDVKLAQKRHKDMNKLKYLMTLLINNALPLPAVYKDHPLQGSWKGYRDAHVEPDWILIYKLTDKLLR
FERTGTHAALFG

Download         Length: 279 bp

>T154858 NZ_CP068285:2953040-2954386 [Ralstonia syzygii subsp. celebesensis]
ATGGGGCGCCGGTCGCATACGCGGGCCCTCGGGCTCTGGATGAATGGCACCCATGTCGGCCACTGGGAGCTGCACCCGCA
TCAAGGCGATGTGCTGAAGTACGCGGCGTCCTGGGTGGCCGCACCCGAGGGGCGGCCCTTGTCGCTATCCCTGCCCTTCA
CGCCGGACAACGCGCCGTACAAAGGCCCGGCGGTCCGGGCATATTTCGAAAACCTCCTGCCGGACAGCCGCGACATCCGC
GAGCGCATCGCGCGCCGGTTCCAGGCGGGCACGACCGAGGCATTCGACCTGCTGGAGCAGATCGGCCGCGACTGCATCGG
CGCCCTGCAGGTGCTGCCCGCCGACATGGCCCCAGCCAGCATCGGCGACATCGACGCGGAGCCGCTGACCGAGGCGCAGA
TCGCGCAGACGCTGCGGGAGACGGTCGCCCCGCCGCCCCTGGGCGGCATGCCGGAGGACGACGGCAATTTCCGCATCTCG
ATTGCCGGCGCGCAGGAAAAGACCGCCTTCCTCCAGATCGACGAACGCTGGTACCGCCCCCGGGGCGCGACGCCGACCAG
CCACATCTTCAAGCTGCCGATGGGGCGGGTCGGCAACATGAAGCTGGACCTGAGCGAGTCGGTGGAAAACGAATGGCTGT
GCTCCCTGGTGCTGCGGGCGTATGGGCTGCCCATCGCCCACTGCCAGCCACTGGTGTTCGAAGACCAGAAAGTCCTGGCC
GTGGAACGGTTCGACCGCATGTGGCGGGACCACCGCGGCAGGCAGCTCATCCGCCTGCCGCAGGAAGACATGTGCCAGGC
GACGGCCACGCCCCCGCACCTGAAGTACGAGGCCGACGGCGGCCCCGGCATCGACCGCATCATGGGCCTGCTCGACGGCT
CCGCGCGCCGGGATGCCGACCGCCTGATGCTGTTCCAGAGCCAGGTGCTGTTCTGGATGCTGTGCGCGCCCGACGGCCAT
GCGAAGAACTTCAGCCTCGCGCTTCGCCCCGGCGGCGCCTACGCGCTCACGCCGCTGTACGACGTGATGTCGGCCTACCC
GCTGCTGGGCGAGGGGCCGGGCAAGCTCTCACCGCACCGGATCCGGCTGGCAATGGCCGTCCGCTCGAAGAACCCGCACT
GGAAAATGCAAGACGTCCAGCGGCGCCACTGGCTGGGCCTGGGCCAGCGGCATGGCATCGTCACGCCCGAGGGCGGGCAT
GCGGCCGCCATCGTGGACAGTCTGGTCGCCCGGACCCCCGAGGTGATCCGCACCGTGCGCGCGCTGCTGCCGGAAGACTT
CCCGCAGCCGCTGGCCGACCGCATTCTGCGGGGGCTGCAGAGCGCCGCGGACAGGCTCGCGCAATAG

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9391.77 Da        Isoelectric Point: 5.0758

>AT154858 WP_000729704.1 NZ_CP051698:3725731-3725991 [Escherichia coli]
MAANAFVRARIDEDLKNQAADVLAGMGLTISDLVRITLTKVAREKALPFDLREPNQLTIQSIKNSEAGVDVHKAKDADDL
FDKLGI

Download         Length: 261 bp

>AT154858 NZ_CP068285:2952769-2953035 [Ralstonia syzygii subsp. celebesensis]
ATGAACGAGTTCATCGTACGCACCCCCGAGCAGTTGCCGGCGATTCTCAAGGGCTTCCGCAAACAGGCCGGGCTGAGCCA
GGCTGAACTGGCCACCCGGATGGGCATGCGCCAGCAAACCCTCTCCGCACTGGAGCGCAACGCAGAAAACGTGAGCGCCG
GACGGCTGATGCGCCTGTTGTCGGTGCTGGGCGTCGAGCTGGTGCTGCGCAAACCCGACGCCTCCGGCGAGCGCGGCCGC
CCGGCATCCGACCAGCCGCAGTGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB U9XPG0

Antitoxin

Source ID Structure
PDB 4ML0
AlphaFold DB A0A0E0Y6Z6

References