Detailed information of TA system TA154855

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): ldrD-sokA/Ldr(toxin)
• Location: 2703814..2704036
• Replicon: chromosome
• Accession: NZ_CP051698
• Organism: Escherichia coli strain SCU-152

Toxin (Protein)

• Gene name: ldrD
• Uniprot ID: B7LGX8
• Locus tag: HHJ40_RS12930
• Protein ID: WP_000170965.1
• Coordinates: 2703929..2704036 (+)
• Length: 36 a.a.

Antitoxin (RNA)

Gene name	sokA
Locus tag	-
Coordinates	2703814..2703881 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HHJ40_RS12905	2699095..2700489	-	1395	WP_000086213.1	inverse autotransporter invasin YchO	-
HHJ40_RS12910	2700674..2701027	+	354	WP_001169669.1	DsrE/F sulfur relay family protein YchN	-
HHJ40_RS12915	2701071..2701766	-	696	WP_001355927.1	glutathione-specific gamma-glutamylcyclotransferase	-
HHJ40_RS12920	2701924..2702154	-	231	WP_001146442.1	putative cation transport regulator ChaB	-
HHJ40_RS12925	2702424..2703524	+	1101	WP_001295620.1	sodium-potassium/proton antiporter ChaA	-
-	2703814..2703881	-	68	NuclAT_13	-	Antitoxin
-	2703814..2703881	-	68	NuclAT_13	-	Antitoxin
-	2703814..2703881	-	68	NuclAT_13	-	Antitoxin
-	2703814..2703881	-	68	NuclAT_13	-	Antitoxin
-	2703814..2703881	-	68	NuclAT_14	-	Antitoxin
-	2703814..2703881	-	68	NuclAT_14	-	Antitoxin
-	2703814..2703881	-	68	NuclAT_14	-	Antitoxin
-	2703814..2703881	-	68	NuclAT_14	-	Antitoxin
-	2703814..2703881	-	68	NuclAT_15	-	Antitoxin
-	2703814..2703881	-	68	NuclAT_15	-	Antitoxin
-	2703814..2703881	-	68	NuclAT_15	-	Antitoxin
-	2703814..2703881	-	68	NuclAT_15	-	Antitoxin
-	2703814..2703881	-	68	NuclAT_16	-	Antitoxin
-	2703814..2703881	-	68	NuclAT_16	-	Antitoxin
-	2703814..2703881	-	68	NuclAT_16	-	Antitoxin
-	2703814..2703881	-	68	NuclAT_16	-	Antitoxin
-	2703814..2703881	-	68	NuclAT_17	-	Antitoxin
-	2703814..2703881	-	68	NuclAT_17	-	Antitoxin
-	2703814..2703881	-	68	NuclAT_17	-	Antitoxin
-	2703814..2703881	-	68	NuclAT_17	-	Antitoxin
-	2703814..2703881	-	68	NuclAT_18	-	Antitoxin
-	2703814..2703881	-	68	NuclAT_18	-	Antitoxin
-	2703814..2703881	-	68	NuclAT_18	-	Antitoxin
-	2703814..2703881	-	68	NuclAT_18	-	Antitoxin
HHJ40_RS12930	2703929..2704036	+	108	WP_000170965.1	type I toxin-antitoxin system toxin Ldr family protein	Toxin
-	2704350..2704416	-	67	NuclAT_19	-	-
-	2704350..2704416	-	67	NuclAT_19	-	-
-	2704350..2704416	-	67	NuclAT_19	-	-
-	2704350..2704416	-	67	NuclAT_19	-	-
-	2704350..2704416	-	67	NuclAT_20	-	-
-	2704350..2704416	-	67	NuclAT_20	-	-
-	2704350..2704416	-	67	NuclAT_20	-	-
-	2704350..2704416	-	67	NuclAT_20	-	-
-	2704350..2704416	-	67	NuclAT_21	-	-
-	2704350..2704416	-	67	NuclAT_21	-	-
-	2704350..2704416	-	67	NuclAT_21	-	-
-	2704350..2704416	-	67	NuclAT_21	-	-
-	2704350..2704416	-	67	NuclAT_22	-	-
-	2704350..2704416	-	67	NuclAT_22	-	-
-	2704350..2704416	-	67	NuclAT_22	-	-
-	2704350..2704416	-	67	NuclAT_22	-	-
-	2704350..2704416	-	67	NuclAT_23	-	-
-	2704350..2704416	-	67	NuclAT_23	-	-
-	2704350..2704416	-	67	NuclAT_23	-	-
-	2704350..2704416	-	67	NuclAT_23	-	-
-	2704350..2704416	-	67	NuclAT_24	-	-
-	2704350..2704416	-	67	NuclAT_24	-	-
-	2704350..2704416	-	67	NuclAT_24	-	-
-	2704350..2704416	-	67	NuclAT_24	-	-
-	2704351..2704414	-	64	NuclAT_25	-	-
-	2704351..2704414	-	64	NuclAT_25	-	-
-	2704351..2704414	-	64	NuclAT_25	-	-
-	2704351..2704414	-	64	NuclAT_25	-	-
-	2704351..2704414	-	64	NuclAT_26	-	-
-	2704351..2704414	-	64	NuclAT_26	-	-
-	2704351..2704414	-	64	NuclAT_26	-	-
-	2704351..2704414	-	64	NuclAT_26	-	-
-	2704351..2704414	-	64	NuclAT_27	-	-
-	2704351..2704414	-	64	NuclAT_27	-	-
-	2704351..2704414	-	64	NuclAT_27	-	-
-	2704351..2704414	-	64	NuclAT_27	-	-
HHJ40_RS12935	2704464..2704571	+	108	WP_000170954.1	type I toxin-antitoxin system toxin Ldr family protein	-
HHJ40_RS12940	2704720..2705574	-	855	WP_000811065.1	3-deoxy-8-phosphooctulonate synthase	-
HHJ40_RS12945	2705610..2706419	-	810	WP_001257044.1	invasion regulator SirB1	-
HHJ40_RS12950	2706423..2706815	-	393	WP_000200378.1	invasion regulator SirB2	-
HHJ40_RS12955	2706812..2707645	-	834	WP_000456571.1	peptide chain release factor N(5)-glutamine methyltransferase	-
HHJ40_RS12960	2707645..2708727	-	1083	WP_000804726.1	peptide chain release factor 1	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Type I toxin-antitoxin system, toxin Ldr (1-35)

Sequences

Toxin

Protein

• Length: 36 a.a.
• Molecular weight: 4001.77 Da
• Isoelectric Point: 11.4779

>T154855 WP_000170965.1 NZ_CP051698:2703929-2704036 [Escherichia coli]
MTLAQFAMTFWHDLAAPILAGIITAAIVSWWRNRK

Nucleotide

• Length: 108 bp

>T154855 NZ_CP068285:c1390227-1389973 [Ralstonia syzygii subsp. celebesensis]
ATGAAAGCCAAACACCAGAAGACGCTGGAGCTGATCTTTTCCCGCCCTACGCCAGCGGGCGTTAAGTGGGCCGATGCCGT
CACGCTCATGCGAGAACTGGGCGCGGAATTGGAGGAGCGCGAGGGTTCTCGCGTGGCCGTCTTCCTGTTTGGTCAAGTTA
AAGTGATGCATCGACCACACCCATCGCCCGATATGGACAAGGGCGCTGTGGCCTCGATGCGTAAGTGGTTCGAGGAAAAC
GGAGTCAAGCCATGA

Antitoxin

Nucleotide

• Length: 68 bp

>AT154855 NZ_CP051698:c2703881-2703814 [Escherichia coli]
GTCTGGTTTCAAGATTAGCCCCCGTTTTGTTGTCAGGTTAAACCTCTCAACGTGCGGGGGTTTTCTCT

Structures

Toxin

• AlphaFold DB: A0A0E0Y029

Antitoxin