Detailed information of TA system TA154840

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): hok-sok/-
• Location: 229062..229319
• Replicon: chromosome
• Accession: NZ_CP051698
• Organism: Escherichia coli strain SCU-152

Toxin (Protein)

• Gene name: hokA
• Uniprot ID: V0YDF1
• Locus tag: HHJ40_RS01070
• Protein ID: WP_001135738.1
• Coordinates: 229167..229319 (+)
• Length: 51 a.a.

Antitoxin (RNA)

Gene name	sokA
Locus tag	-
Coordinates	229062..229116 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HHJ40_RS01050	224287..225282	-	996	WP_001182653.1	O-acetyltransferase WecH	-
HHJ40_RS01055	225457..225756	+	300	WP_000980104.1	membrane protein	-
HHJ40_RS01060	225851..226762	+	912	WP_001168544.1	glycine--tRNA ligase subunit alpha	-
HHJ40_RS01065	226772..228841	+	2070	WP_001291774.1	glycine--tRNA ligase subunit beta	-
-	229062..229116	-	55	-	-	Antitoxin
HHJ40_RS01070	229167..229319	+	153	WP_001135738.1	type I toxin-antitoxin system toxin HokA	Toxin
HHJ40_RS01075	229507..229719	-	213	WP_000014594.1	RNA chaperone/antiterminator CspA	-
HHJ40_RS01080	230000..230290	-	291	WP_000455798.1	HTH-type transcriptional regulator	-
HHJ40_RS01085	230724..231434	+	711	WP_000190517.1	DUF3053 domain-containing protein	-
HHJ40_RS01090	231484..232458	-	975	WP_000805027.1	glyoxylate/hydroxypyruvate reductase GhrB	-
HHJ40_RS01095	232562..233221	-	660	WP_000747625.1	OmpA family lipoprotein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Hok/gef cell toxic protein (5-46)

Sequences

Toxin

Protein

• Length: 51 a.a.
• Molecular weight: 5912.14 Da
• Isoelectric Point: 7.7173

>T154840 WP_001135738.1 NZ_CP051698:229167-229319 [Escherichia coli]
MPQKYRLLSLIVICFTLLFFTWMIRDSLCELHIKQGSYELAAFLACNLKE

Nucleotide

• Length: 153 bp

>T154840 NZ_CP068283:2814435-2815508 [Escherichia coli]
ATGACAATCAGGAGTTACAAAAACTTAAATCTGGTCAGGGCAAATATCGAGACTGAATCCAGACAATTCATTGAAAATAA
AAACTATTCAATCCAATCAATTGGTCCTATGCCAGGGTCAAGGGCTGGGCTTCGGGTCGTATTTACCAGACCAGGGGTTA
ACTTGGCAACTGTGGACATTTTTTATAACGGGGACGGTTCGACTACAATTCAATATCTCACTGGAGCCAATCGTTCTCTG
GGCCAAGAGTTAGCGGATCATCTTTTTGAAACCATCAATCCTGCTGAATTTGAGCAGGTAAATATGGTACTGCAAGGATT
TGTAGAGACAAGCGTTCTACCTGTACTTGAGCTATCAGCAGATGAATCGCATATAGAGTTCAGAGAACACTCTCGTAACG
CTCATACCGTAGTGTGGAAAATTATTTCCACCAGCTATCAGGACGAATTGACTGTGAGCCTGCATATCACAACAGGTAAG
CTCCAGATTCAGGGCCGACCGCTGTCATGTTACAGAGTTTTCACGTTTAACTTGGCAGCCCTGCTTGATTTACAGGGTTT
GGAGAAAGTGCTAATCCGCCAGGAGGATGGTAAAGCTAATATTGTTCAACAGGAGGTTGCCCGCACTTACTTGCAGACTG
TAATGGCCGATGCTTACCCGCATCTCCACGTGACTGCCGAAAAATTGCTCGTTTCAGGGCTATGTGTTAAACTCGCCGCC
CCTGATTTGCCTGACTACTGTATGTTACTTTATCCTGAACTACGCACCATTGAAGGTGTCTTAAAAAGTAAGATGAGTGG
GTTAGGCATGCCAGTACAGCAGCCGGCAGGTTTTGGAACTTACTTTGATAAACCTGCTGCTCATTACATTCTGAAACCGC
AATTTGCAGCTACTCTTAGACCGGAACAGATTAACATCATCAGCACAGCCTATACTTTTTTTAATGTGGAACGTCATTCT
CTGTTCCACATGGAAACTGTGGTCGATGCCAGCCGTATGATTTCTGATATGGCCCGGTTGATGGGTAAAGCCACTAGAGC
GTGGGGAATAATCAAGGACTTATATATTGTTTGA

Antitoxin

Nucleotide

• Length: 55 bp

>AT154840 NZ_CP051698:c229116-229062 [Escherichia coli]
GTTCAGGCATAGGGTAGCCTCACTTTGATTTATAGTCAGGTGGGGCTTTTCTCTG

Structures

Toxin

• AlphaFold DB: A0A7U9LX93

Antitoxin