Detailed information of TA system TA154822

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): hok-sok/-
• Location: 4255356..4255614
• Replicon: chromosome
• Accession: NZ_CP051694
• Organism: Escherichia coli strain SCU-313

Toxin (Protein)

• Gene name: hokC
• Uniprot ID: S1NX00
• Locus tag: HHJ46_RS20490
• Protein ID: WP_000809168.1
• Coordinates: 4255462..4255614 (+)
• Length: 51 a.a.

Antitoxin (RNA)

Gene name	sokC
Locus tag	-
Coordinates	4255356..4255413 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HHJ46_RS20475	4251748..4252707	+	960	WP_000871674.1	hypothetical protein	-
HHJ46_RS20480	4252745..4253644	-	900	WP_001300855.1	transcriptional activator NhaR	-
HHJ46_RS20485	4253710..4254876	-	1167	WP_000681360.1	Na+/H+ antiporter NhaA	-
-	4255356..4255413	-	58	-	-	Antitoxin
HHJ46_RS20490	4255462..4255614	+	153	WP_000809168.1	type I toxin-antitoxin system toxin MokC	Toxin
HHJ46_RS20495	4255718..4256848	-	1131	WP_001118464.1	molecular chaperone DnaJ	-
HHJ46_RS20500	4256937..4258853	-	1917	WP_000516135.1	molecular chaperone DnaK	-
HHJ46_RS20505	4259229..4259633	+	405	WP_000843584.1	DUF2541 family protein	-
HHJ46_RS20510	4259659..4260372	+	714	WP_001102367.1	acidic protein MsyB	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Hok/gef cell toxic protein (6-47)

Sequences

Toxin

Protein

• Length: 51 a.a.
• Molecular weight: 5501.57 Da
• Isoelectric Point: 7.1312

>T154822 WP_000809168.1 NZ_CP051694:4255462-4255614 [Escherichia coli]
MKQHKAMIVALIVICITAVVAALVTRKDLCEVHIRTGQTEVAVFTAYESE

Nucleotide

• Length: 153 bp

>T154822 NZ_CP068282:c28489-28091 [Escherichia coli]
ATGCTGAAGTTTATGCTCGATACCAACATCTGCATTTTTACGATAAAGAACAAACCCGCCAGTGTCAGGGAACGTTTTAA
CCTGAACCAGGGGAGAATGTGCATCAGTTCGGTCACTCTGATGGAGGTGATATATGGTGCAGAAAAAAGCCAGATGCCTG
AACGTAATCTCGCTGTGATCGAGGGATTTGTTTCCCGCATTGACGTTCTGGATTACGACGCTGCTGCTGCCACACACACC
GGCCAGATAAGAGCAGAACTTGCCCTTCAGGGACGCCCTGTCGGGCCATTTGATCAAATGATCGCAGGTCATGCCCGCAG
TCGGGGACTGATTATTGTGACTAATAACACCCGGGAATTTGAACGTGTGGGCGGCCTGAGAATTGAAGACTGGAGTTGA

Antitoxin

Nucleotide

• Length: 58 bp

>AT154822 NZ_CP051694:c4255413-4255356 [Escherichia coli]
GTTCAGCATATAGGGGGCCTCGGGTTGATGGTAAAATATCACTCGGGGCTTTTCTCTA

Structures

Toxin

• AlphaFold DB: S1NX00

Antitoxin