Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-YefM
Location 1959362..1959864 Replicon chromosome
Accession NZ_CP051694
Organism Escherichia coli strain SCU-313

Toxin (Protein)


Gene name yoeB Uniprot ID E2QNP2
Locus tag HHJ46_RS09200 Protein ID WP_000767819.1
Coordinates 1959610..1959864 (+) Length 85 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID E2QNP3
Locus tag HHJ46_RS09195 Protein ID WP_001259253.1
Coordinates 1959362..1959613 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HHJ46_RS09170 1954540..1955607 - 1068 WP_000080057.1 bifunctional histidinol-phosphatase/imidazoleglycerol-phosphate dehydratase HisB -
HHJ46_RS09175 1955607..1956677 - 1071 WP_000108967.1 histidinol-phosphate transaminase -
HHJ46_RS09180 1956674..1957978 - 1305 WP_001296211.1 histidinol dehydrogenase -
HHJ46_RS09185 1957984..1958883 - 900 WP_000131782.1 ATP phosphoribosyltransferase -
HHJ46_RS09190 1959029..1959079 - 51 WP_001364200.1 his operon leader peptide -
HHJ46_RS09195 1959362..1959613 + 252 WP_001259253.1 YoeB-YefM toxin-antitoxin system antitoxin YefM Antitoxin
HHJ46_RS09200 1959610..1959864 + 255 WP_000767819.1 type II toxin-antitoxin system mRNA interferase toxin YoeB Toxin
HHJ46_RS09205 1959947..1960771 + 825 WP_000754737.1 SDR family oxidoreductase -
HHJ46_RS09210 1960817..1961746 + 930 WP_000803366.1 LysR family transcriptional regulator -
HHJ46_RS09215 1961961..1962023 + 63 WP_010723108.1 membrane protein YoeI -
HHJ46_RS09220 1962013..1963371 + 1359 WP_000019194.1 putrescine/proton symporter PlaP -
HHJ46_RS09225 1963555..1964252 + 698 Protein_1805 IS1 family transposase -
HHJ46_RS09230 1964364..1964822 + 459 WP_000526135.1 IS200/IS605 family transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(2-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-72)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 10110.53 Da        Isoelectric Point: 7.2749

>T154805 WP_000767819.1 NZ_CP051694:1959610-1959864 [Escherichia coli]
VKLIWSEESWDDYLYWQEADKRIVKKINELIKDTRRTPFEGKGKPEPLKHNLSGFWSRRITEEHLLVYAVTDDSLLIAAC
RYHY

Download         Length: 255 bp

>T154805 NZ_CP068281:c2513111-2513004 [Escherichia coli]
ATGACGCTCGCGCAGTTTGCCATGACTTTCTGGCACGACCTGGCGGCACCGATCCTGGCGGGAATTATTACCGCAGCGAT
TGTCGGCTGGTGGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9365.62 Da        Isoelectric Point: 4.6127

>AT154805 WP_001259253.1 NZ_CP051694:1959362-1959613 [Escherichia coli]
MRTISYSEARQNLSATMMKAVEDHAPILITRQNGEACVLMSLEEYNSLEETAYLLRSPANARRLMDSIDSLKSDKGTEKD
IIE

Download         Length: 252 bp

>AT154805 NZ_CP068281:2513158-2513224 [Escherichia coli]
TGTCTGGTTTCAAGATTAGCCCCCGTTCTGTTGTCAGGTTTTACCTCTCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB E2QNP2

Antitoxin

Source ID Structure
AlphaFold DB E2QNP3

References