Detailed information of TA system TA154755

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): symE-agrB/SymE(toxin)
• Location: 640770..641182
• Replicon: chromosome
• Accession: NZ_CP051688
• Organism: Escherichia coli strain SCU-387

Toxin (Protein)

• Gene name: symE
• Uniprot ID: S1NWQ7
• Locus tag: HHJ48_RS03040
• Protein ID: WP_000132614.1
• Coordinates: 640770..641111 (-)
• Length: 114 a.a.

Antitoxin (RNA)

Gene name	agrB
Locus tag	-
Coordinates	641106..641182 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HHJ48_RS03020	635839..637119	-	1281	WP_001338077.1	DUF445 domain-containing protein	-
HHJ48_RS03025	637304..638224	+	921	WP_001513532.1	Rpn family recombination-promoting nuclease/putative transposase	-
HHJ48_RS03030	638452..638532	+	81	WP_020233658.1	hypothetical protein	-
HHJ48_RS03035	638567..640723	+	2157	WP_001513533.1	DUF262 domain-containing protein	-
HHJ48_RS03040	640770..641111	-	342	WP_000132614.1	endoribonuclease SymE	Toxin
-	641106..641182	+	77	NuclAT_5	-	Antitoxin
-	641106..641182	+	77	NuclAT_5	-	Antitoxin
-	641106..641182	+	77	NuclAT_5	-	Antitoxin
-	641106..641182	+	77	NuclAT_5	-	Antitoxin
-	641106..641182	+	77	NuclAT_6	-	Antitoxin
-	641106..641182	+	77	NuclAT_6	-	Antitoxin
-	641106..641182	+	77	NuclAT_6	-	Antitoxin
-	641106..641182	+	77	NuclAT_6	-	Antitoxin
HHJ48_RS03045	641332..643101	-	1770	WP_001513535.1	restriction endonuclease subunit S	-
HHJ48_RS03050	643101..644570	-	1470	WP_001387312.1	type I restriction-modification system subunit M	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	cheD	640770..657138	16368

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin SymE-like (20-71)

Sequences

Toxin

Protein

• Length: 114 a.a.
• Molecular weight: 12266.07 Da
• Isoelectric Point: 8.4982

>T154755 WP_000132614.1 NZ_CP051688:c641111-640770 [Escherichia coli]
MTDTHSIAQPFEAEVSPANNRQLTVSYASRYPDYSRIPAITLKGQWLEAAGFATGTAVDVKVMEGCIVLTAQPPAAAESE
LMQSLRQVCKLSARKQRQVQEFIGVIAGKQKVA

Nucleotide

• Length: 342 bp

>T154755 NZ_CP068249:c2939820-2939479 [Enterococcus faecalis]
ATGAACGTTGAAAAGAAGTACATTCCCAAAAAAGGAGATATTGTATGGATTGATTTTGATCCTGCTGCAGGTAAAGAAAT
TCAGAAGAGACGCCCTGGTTTAGTCGTGTCAAGATATGAATTTAATCGGAAAACCATGTTTGCTGCGATTTGCCCGATTA
CTTCCACCATTAAAAATATTCCCACTCGATATACGTTGCCCGATGACATAGAAACCCAAGGACAAGTAGTGATCTCACAA
CTGAAATCTTTGGACTTCACTGAAAGAAAATTAAGTCAAATTGAGCATTTGCCATTAAAAGATATGGCGAAAATTGACCA
AATAATTGAATATATTTTCTAG

Antitoxin

Nucleotide

• Length: 77 bp

>AT154755 NZ_CP051688:641106-641182 [Escherichia coli]
AGTCATAACTGCTATTCCCTATAAATAGTGATTGTGATTAGCGGTGCGGGTGTGTTGGCGCACATCCGCACCGCGCT

Structures

Toxin

• AlphaFold DB: S1NWQ7

Antitoxin