Detailed information of TA system TA154747

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): higBA (relBE)/HigB-HigA
• Location: 3147640..3148203
• Replicon: chromosome
• Accession: NZ_CP051684
• Organism: Duganella sp. AF9R3

Toxin (Protein)

• Gene name: graT
• Uniprot ID: -
• Locus tag: HH213_RS14345
• Protein ID: WP_169112660.1
• Coordinates: 3147919..3148203 (-)
• Length: 95 a.a.

Antitoxin (Protein)

• Gene name: graA
• Uniprot ID: -
• Locus tag: HH213_RS14340
• Protein ID: WP_110846580.1
• Coordinates: 3147640..3147906 (-)
• Length: 89 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HH213_RS14325	3145420..3146235	+	816	WP_169112657.1	polysaccharide deacetylase family protein	-
HH213_RS14330	3146222..3147235	+	1014	WP_169112658.1	LacI family DNA-binding transcriptional regulator	-
HH213_RS14335	3147189..3147485	-	297	WP_169112659.1	HigA family addiction module antidote protein	-
HH213_RS14340	3147640..3147906	-	267	WP_110846580.1	HigA family addiction module antidote protein	Antitoxin
HH213_RS14345	3147919..3148203	-	285	WP_169112660.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
HH213_RS14350	3148291..3150303	-	2013	WP_169112661.1	S9 family peptidase	-
HH213_RS14355	3150499..3151413	+	915	WP_169112662.1	LysR family transcriptional regulator	-
HH213_RS14360	3151419..3152687	-	1269	WP_169112663.1	Nramp family divalent metal transporter	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	3147640..3158455	10815

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-1 (24-93)

Antitoxin

• Toxin-antitoxin system, antidote protein, HigA (1-83)

Sequences

Toxin

Protein

• Length: 95 a.a.
• Molecular weight: 10859.41 Da
• Isoelectric Point: 10.2241

>T154747 WP_169112660.1 NZ_CP051684:c3148203-3147919 [Duganella sp. AF9R3]
MPIQSFKCRDTEKVFNNLAVPRFAQFRSALERKLRQLNIANDLDDLRVPTGNRLEALAGTRQGQHSIRINKRYRICFVWT
AAGPSEVELVDYHS

Nucleotide

• Length: 285 bp

>T154747 NZ_CP068247:c1514013-1513651 [Staphylococcus sp. T93]
ATGATTAGACGAGGAGATGTTTATTTAGCAGATTTATCACCAGTACAGGGATCTGAACAAGGGGGAGTCAGACCTGTAGT
CATAATTCAAAATGATACTGGTAATAAATATAGTCCTACAGTTATTGTTGCGGCAATAACTGGTAGGATTAATAAAGCGA
AAATACCGACACATGTAGAGATTGAAAAGAAAAAGTATAAGTTGGATAAAGACTCAGTTATATTATTAGAACAAATTCGT
ACACTTGATAAAAAACGATTGAAAGAAAAACTGACGTACTTATCCGATGATAAAATGAAAGAAGTAGATAATGCACTAAT
GATTAGTTTAGGGCTGAATGCAGTAGCTCACCAGAAAAATTAG

Antitoxin

Protein

• Length: 89 a.a.
• Molecular weight: 9990.62 Da
• Isoelectric Point: 6.3229

>AT154747 WP_110846580.1 NZ_CP051684:c3147906-3147640 [Duganella sp. AF9R3]
MLEDKMRPIHPGEILREDFMVPLKMKPVAFANMLDLPVAVVAEVLGEKRSVSTEIATHIVQHFGGHVDFWLRLQQNYDDK
IAQGNHGI

Nucleotide

• Length: 267 bp

>AT154747 NZ_CP068247:c1514180-1514010 [Staphylococcus sp. T93]
ATGTTATCTTTTAGTCAAAATAGAAGTCATAGCTTAGAACAATCTTTAAAAGAAGGATATTCACAAATGGCTGATTTAAA
TCTCTCCCTAGCGAACGAAGCTTTTCCGATAGAGTGTGAAGCATGCGATTGCAACGAAACATATTTATCTTCTAATTCAA
CGAATGAATGA