Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 2236489..2237027 Replicon chromosome
Accession NZ_CP051684
Organism Duganella sp. AF9R3

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag HH213_RS10220 Protein ID WP_110846652.1
Coordinates 2236749..2237027 (-) Length 93 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag HH213_RS10215 Protein ID WP_169112186.1
Coordinates 2236489..2236749 (-) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HH213_RS10190 2232110..2232556 - 447 WP_169112182.1 SRPBCC family protein -
HH213_RS10195 2232688..2233878 + 1191 WP_169112183.1 TonB family protein -
HH213_RS10200 2234005..2234763 + 759 WP_169112184.1 M48 family metalloprotease -
HH213_RS10205 2234770..2235933 - 1164 WP_110845864.1 GGDEF domain-containing protein -
HH213_RS10210 2236025..2236492 + 468 WP_169112185.1 heme-degrading domain-containing protein -
HH213_RS10215 2236489..2236749 - 261 WP_169112186.1 HigA family addiction module antidote protein Antitoxin
HH213_RS10220 2236749..2237027 - 279 WP_110846652.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
HH213_RS10225 2237100..2237306 - 207 WP_161055165.1 SlyX family protein -
HH213_RS10230 2237303..2239381 - 2079 WP_169112187.1 UvrD-helicase domain-containing protein -
HH213_RS10235 2239526..2240008 + 483 WP_110845869.1 DUF1857 family protein -
HH213_RS10240 2240018..2241109 - 1092 WP_169115087.1 HD domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 2223421..2237306 13885


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(4-92)

Antitoxin

Toxin-antitoxin system, antidote protein, HigA

(7-84)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10394.90 Da        Isoelectric Point: 9.1735

>T154746 WP_110846652.1 NZ_CP051684:c2237027-2236749 [Duganella sp. AF9R3]
VITSFKHKGLYRLYAYGAHAGIPCAHAARIVRMLDRLNSCCEPADMDLPGYKFHPLKGSRQGTYSVQVSGNWRITFCFAN
GNAFNVRLEDYH

Download         Length: 279 bp

>T154746 NZ_CP068247:c1355836-1355684 [Staphylococcus sp. T93]
ATGTCTAAAGACAAAGATCCAAAATTAAATTATCATGAAGAAGAAAACAGTATGGTAACGGATTTTGAAGATTTAAAAGA
ATTAGGTAAAGAAATGGAACAAATCTCTGATCAAAATGATCAAGAAAAGAATTCTGAAGAAGACAGTCAGTAA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9700.18 Da        Isoelectric Point: 6.7231

>AT154746 WP_169112186.1 NZ_CP051684:c2236749-2236489 [Duganella sp. AF9R3]
MNTLRDAKRRPTHPGAMLREDVLPELKISPAAFAEHLGISVQSLQELLLEQRPLTADVAQQLAVYLKTSPESWLRMQHAV
DNWVTA

Download         Length: 261 bp

>AT154746 NZ_CP068247:c1356460-1355861 [Staphylococcus sp. T93]
ATGGCAATGAACTTTAAAGTCTTTGACAATAGTCAACTTGTAGCAGAATATGCTGCTGATATTATTAGAAAGCAATTTAA
CAATAATCCTACTACAATTGCAGGTTTTCATTTAGATACAGATCAAGCGCCAGTTCTAGATGAATTAAAGAAAAATGTTG
AAAAACATGCTGTTGATTTTAGCCAAATAAATATTTTAGATTATGACGATAAAAAATCATATTTCGAAGCGTTAGGTGTA
CCAGCAGGTCAAGTTTATCCAATTGCTTATGAAAAAGATGCAATCGAATTAATCGCTGATAAGATTAAAACTAAAGAAAA
TAAAGGGAAATTAACATTACAAGTTGTTTCTATCGATGAGCAAGGTAAGTTAAATGTTAGTATTCGTCAAGGACTAATGG
AAGCAAGAGAAATTTTCTTAGTAGTGACAGGTGCTAATAAACGAGATGTAGTTGAAAAATTATATCAAGAAAATGGTAAA
ACAAGCTTCGAACCAGCCGATTTAAAAGCACATAGAATGGTAAATGTTATTCTTGATAAAGAAGCGGCTGCAGGTTTACC
TGAAGATGTTAAAGCTTACTTTACGTCACGCTTTGCTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References