Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) prlF-yhaV (relBE)/YhaV-PrlF
Location 2530487..2531286 Replicon chromosome
Accession NZ_CP051663
Organism Escherichia coli strain 1162invT2

Toxin (Protein)


Gene name yhaV Uniprot ID S1NYM6
Locus tag HH200_RS12485 Protein ID WP_000347251.1
Coordinates 2530822..2531286 (+) Length 155 a.a.

Antitoxin (Protein)


Gene name prlF Uniprot ID S1PPV5
Locus tag HH200_RS12480 Protein ID WP_001296435.1
Coordinates 2530487..2530822 (+) Length 112 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HH200_RS12465 (2526272) 2526272..2527042 - 771 WP_001058227.1 2-dehydro-3-deoxyglucarate aldolase -
HH200_RS12470 (2527058) 2527058..2528392 - 1335 WP_000599651.1 galactarate/glucarate/glycerate transporter GarP -
HH200_RS12475 (2528767) 2528767..2530338 + 1572 WP_001273763.1 galactarate dehydratase -
HH200_RS12480 (2530487) 2530487..2530822 + 336 WP_001296435.1 type II toxin-antitoxin system antitoxin PrlF Antitoxin
HH200_RS12485 (2530822) 2530822..2531286 + 465 WP_000347251.1 type II toxin-antitoxin system ribonuclease toxin YhaV Toxin
HH200_RS12490 (2531341) 2531341..2532150 - 810 WP_000072187.1 aga operon transcriptional regulator AgaR -
HH200_RS12495 (2532399) 2532399..2533679 + 1281 WP_000681950.1 tagatose-bisphosphate aldolase subunit KbaZ -
HH200_RS12500 (2533702) 2533702..2534175 + 474 WP_001295547.1 PTS N-acetylgalactosamine transporter subunit IIB -
HH200_RS12505 (2534186) 2534186..2534965 + 780 WP_000406214.1 PTS N-acetylgalactosamine transporter subunit IIC -
HH200_RS12510 (2534955) 2534955..2535833 + 879 WP_001295548.1 PTS N-acetylgalactosamine transporter subunit IID -
HH200_RS12515 (2535851) 2535851..2536285 + 435 WP_000948824.1 PTS galactosamine/N-acetylgalactosamine transporter subunit IIA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin endonuclease, YhaV

(12-150)

Antitoxin

PrlF antitoxin

(14-110)


Sequences

Toxin        


Download         Length: 155 a.a.        Molecular weight: 17777.14 Da        Isoelectric Point: 9.4947

>T154720 WP_000347251.1 NZ_CP051663:2530822-2531286 [Escherichia coli]
MDFPQRVNGWALYAHPCFQETYDALVAEVEALKGKDPENYQRKAATKLLAVVHKVIEEHITVNPSSPAFRHGKSLGSGKN
KDWSRVKFGAGRYRLFFRYSEKEKVIILGWMNDENTLRTYGKKTDAYTVFSKMLKRGHPPADWESLTQETEENH

Download         Length: 465 bp

>T154720 NZ_CP068237:802035-802445 [Klebsiella quasipneumoniae]
GTGGTCCTGTGGCAATCTGATCTCCGTATCTCCTGGCGCGCGCAGTGGTTTTCCCTGCTGCTCCACGGCGTTGTGGCGGC
GCTGGTGCTGCTGGTTCCCTGGCCGTTAAGCTACACCCCGATCTGGCTGCTGCTGCTGTCGCTGGTGGTCTTTGACTGTG
TGCGCAGCCAGCGACGGATCCATGCCCGTCGCGGGGAGATAAAACTGCTCACCGATTCCCGGCTGCGCTGGCAAAACGCC
GAATGGGAGATCCTCGGGACGCCGTGGGTCATCAACAGCGGTATGCTGCTGCGTTTGCGCCATGTCGATACCCGACGCGG
TCAGCATCTGTGGCTGGCGGCGGACAGCATGGATGCCGGAGAGTGGCGGGACCTGCGCCGGCTGGTGCTGCAAAAACCGG
CGCAGGAGTAA

Antitoxin


Download         Length: 112 a.a.        Molecular weight: 12321.92 Da        Isoelectric Point: 4.5392

>AT154720 WP_001296435.1 NZ_CP051663:2530487-2530822 [Escherichia coli]
MPANARSNAVLTTESKVTIRGQTTIPAPVREALKLKPGLDSIHYEILPGGQVFMCRLGDEQEDHTMNAFLRFLDADIQNN
PQKTRPFDIQQGKKLVAGMDVNIDDEIGDDE

Download         Length: 336 bp

>AT154720 NZ_CP068237:801788-802054 [Klebsiella quasipneumoniae]
ATGGACATTAACAATAAAGCACGTATCCACTGGGCATGCCGCCGCGGGATGCGCGAACTCGACATCTCCATCATGCCGTT
CTTTGAGTATGAGTACGATACCCTCAGCGACGCTGACAAACAGCTGTTCATTCGCCTGCTGGAAAATGACGATCCGGACC
TCTTCAACTGGCTGATGAACCACGGCAAACCGGCCGATGCGGAGCTGCAGCGGATGGTAACCTTAATTCAGACACGGAAT
CGGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829CJ20

Antitoxin

Source ID Structure
AlphaFold DB S1PPV5

References